Co, Cu, Ni, and Zn complexes of N-[(3-phenoxy phenyl)methylidene]-l-valine as α-glycosidase and α-amylase inhibitors: Synthesis, molecular docking & antimicrobial evaluation DOI
R. Sankar,

T.M. Sharmila

Bioorganic Chemistry, Год журнала: 2024, Номер 154, С. 108010 - 108010

Опубликована: Ноя. 29, 2024

Язык: Английский

Theoretical Insights and Anticancer Potential of 2,6‐Bis((E)‐(2‐amino‐4‐nitrophenylimino)methyl)‐4‐methoxyphenol and Its Binuclear Cu(II) Complex DOI Open Access

S. G. Praveen,

G. Parinamachivayam,

P. Jeyaraman

и другие.

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(2)

Опубликована: Янв. 19, 2025

ABSTRACT This study explores the synthesis and applications of a new Schiff base, 2,6‐bis(( E )‐(2‐amino‐4‐nitrophenylimino)methyl)‐4‐methoxyphenol (HL), its copper(II) complexes. The base was prepared by reacting 2‐amino‐4‐nitroaniline with 2,6‐diformyl‐4‐methoxyphenol characterized using techniques like microanalysis, UV–Vis, IR spectroscopy, 1 H‐NMR, LC–MS, confirming structure. Theoretical studies provided insights into molecular geometry electronic properties. Cyclic voltammetry copper complex revealed diffusion‐controlled electrochemical behavior, involving single‐electron transfer. Both Cu(II) complexes exhibited promising anticorrosion anticancer activities, highlighting their multifunctional potential in industrial biomedical applications. emphasizes importance comprehensive characterization developing innovative materials practical uses.

Язык: Английский

Процитировано

2
Advanced synthesis, comprehensive characterization, and potent cytotoxicity of 2,6-Bis(2-aminophenylimino)methyl)-4-methoxyphenol and its binuclear copper(II) complex DOI Creative Commons

S. G. Praveen,

R. Prabakarakrishnan,

G. Parinamachivayam

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 26, 2025

The imine base and Cu2+ precursors were combined using magnetic stirring to formulate the complexes. formation of was confirmed by electronic vibrational spectra, proton NMR, LC-mass spectrometry, computational studies, which also optimized final structure. complexes characterized susceptibility, molar conductivity, a variable temperature magnetometer, ESR spectroscopy. Cyclic voltammetry revealed electron transfer from Cu+ within complex. in vitro tumour activity evaluated on A431 cell line MTT assay. DFT studies validated structural stability base. antiferromagnetic behaviour observed at low temperatures suggests that these could be useful heavy materials. Due their properties, hold potential for use electroplating systems sensors. exhibited high efficacy line, aligning with clinical objectives. are represented as [MLR], where M is metal, L base, R = [C₆H₅COO] or [C₆H₄COO(NH₂)].

Язык: Английский

Процитировано

0
Cytotoxicity, CT-DNA/BSA interaction and antioxidant activity of Ni(II), Cu(II) and Zn(II) complexes derived from a design nematogenic L-Alanyl-glycine based Schiff base ligand DOI

Jagritima Chetia,

Hunshisha Pyngrope,

Bandashisha Kharpan

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141858 - 141858

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
3-Phenoxybenzaldehyde and Glycine-Derived Schiff base M(II) Complexes: Synthesis, molecular Modeling, spectroscopic Exploration, and antimicrobial evaluation DOI
R. Sankar,

T.M. Sharmila

Inorganic Chemistry Communications, Год журнала: 2024, Номер 162, С. 112253 - 112253

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

3
Laminated dihydrazone Zn(II) coordination polymer with prospects for sensory and multifunctional biomedical applications DOI
Olga Danilescu, П. Боурош, I. Bulhac

и другие.

Polyhedron, Год журнала: 2024, Номер 258, С. 117039 - 117039

Опубликована: Май 15, 2024

Язык: Английский

Процитировано

2
Novel Copper (II) Complexes with Fluorine-Containing Reduced Schiff Base Ligands Showing Marked Cytotoxicity in the HepG2 Cancer Cell Line DOI Open Access

Bianka Oboňová,

Jindra Valentová,

Miroslava Litecká

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9166 - 9166

Опубликована: Авг. 23, 2024

Several novel copper (II) complexes of reduced Schiff bases containing fluoride substituents were prepared and structurally characterized by single-crystal X-ray diffraction. The exhibited diverse structures, with the central atom in distorted tetrahedral geometry. biological effects products evaluated, specifically their cytotoxicity, antimicrobial, antiurease activities, as well affinity for albumin (BSA) DNA (ct-DNA). showed marked cytotoxic activities HepG2 hepatocellular carcinoma cell line, considerably higher than standard cisplatin. cytotoxicity depended significantly on substitution pattern. best activity was observed complex a trifluoromethyl group position 4 benzene ring-the dichloro[(±)-trans-

Язык: Английский

Процитировано

2
Macrocyclic Schiff Base Complexes of Zn(II), Cu(II), Co(II), and Ni(II) Targeting Topoisomerase IIβ: Synthesis, Docking, and Evaluation as Potential Anticancer Agents DOI
Monika Yadav, Deepak Yadav,

Singh Dhanesh

и другие.

Applied Organometallic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

ABSTRACT This study explores the potential of newly synthesized macrocyclic Schiff base metal complexes containing Zn(II), Cu(II), Ni(II) and Co(II) ions as Topoisomerase IIβ inhibitors. The were derived from condensation 2,3‐diamino‐5‐bromopyridine 2,5‐thiophenedicarboxaldehyde. Their formation was confirmed through various spectroscopic techniques. To gain insights into their structure biological activity, computational modeling employed. density functional theory (DFT) utilized to optimize molecular geometries complexes. Furthermore, in silico docking simulations with AutoDock Vina GOLD scoring function investigated binding interactions IIβ, an enzyme critical for cancer cell proliferation. combined analysis revealed promising affinities all complexes, complex 3b demonstrating most favorable interaction target having energy −8.56 kcal/mol. validate these predictions, cytotoxicity evaluated using established MTT assay. observed results complemented anticipated patterns, Cu(II) strongest inhibitory effect on cells IC 50 value 0.04 μM. Additionally, hemolytic human red blood (hRBCs) assessed determine biocompatibility. strong correlation between predicted interactions, cytotoxicity, minimal highlights particularly , leads developing novel anticancer drugs targeting IIβ. Future research will focus elucidating detailed mechanism action exploring broader pharmacological profile.

Язык: Английский

Процитировано

1
mer-Bis(quinoline-2-carboxaldehyde 4-ethylthiosemicarbazonato)nickel(II) methanol 0.33-solvate 0.67-hydrate DOI Creative Commons

R. ADAM,

Natasha Ann Keasberry, M.H.S.A. Hamid

и другие.

IUCrData, Год журнала: 2024, Номер 9(4)

Опубликована: Апрель 26, 2024

In the title compound, [Ni(C 13 H N 4 S) 2 ]·0.33CH 3 OH·0.67H O, Ni II atom is coordinated by two tridentate quinoline-2-carboxaldehyde 4-ethylthiosemicarbazonate ligands in a distorted octahedral shape. At 100 K, crystal symmetry monoclinic (space group P 1 / n ). A mixture of water and methanol crystallizes with complex, one ethyl groups coordinating disordered over positions, an occupancy ratio 58:42. There intermolecular hydrogen bonding between solvent molecules amine thiolate ligands. No other significant interactions are present packing.

Язык: Английский

Процитировано

0
Co, Cu, Ni, and Zn complexes of N-[(3-phenoxy phenyl)methylidene]-l-valine as α-glycosidase and α-amylase inhibitors: Synthesis, molecular docking & antimicrobial evaluation DOI
R. Sankar,

T.M. Sharmila

Bioorganic Chemistry, Год журнала: 2024, Номер 154, С. 108010 - 108010

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

0