Co, Cu, Ni, and Zn complexes of N-[(3-phenoxy phenyl)methylidene]-l-valine as α-glycosidase and α-amylase inhibitors: Synthesis, molecular docking & antimicrobial evaluation DOI
R. Sankar,

T.M. Sharmila

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108010 - 108010

Published: Nov. 29, 2024

Language: Английский

Theoretical Insights and Anticancer Potential of 2,6‐Bis((E)‐(2‐amino‐4‐nitrophenylimino)methyl)‐4‐methoxyphenol and Its Binuclear Cu(II) Complex DOI Open Access

S. G. Praveen,

G. Parinamachivayam,

P. Jeyaraman

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 19, 2025

ABSTRACT This study explores the synthesis and applications of a new Schiff base, 2,6‐bis(( E )‐(2‐amino‐4‐nitrophenylimino)methyl)‐4‐methoxyphenol (HL), its copper(II) complexes. The base was prepared by reacting 2‐amino‐4‐nitroaniline with 2,6‐diformyl‐4‐methoxyphenol characterized using techniques like microanalysis, UV–Vis, IR spectroscopy, 1 H‐NMR, LC–MS, confirming structure. Theoretical studies provided insights into molecular geometry electronic properties. Cyclic voltammetry copper complex revealed diffusion‐controlled electrochemical behavior, involving single‐electron transfer. Both Cu(II) complexes exhibited promising anticorrosion anticancer activities, highlighting their multifunctional potential in industrial biomedical applications. emphasizes importance comprehensive characterization developing innovative materials practical uses.

Language: Английский

Citations

2
Advanced synthesis, comprehensive characterization, and potent cytotoxicity of 2,6-Bis(2-aminophenylimino)methyl)-4-methoxyphenol and its binuclear copper(II) complex DOI Creative Commons

S. G. Praveen,

R. Prabakarakrishnan,

G. Parinamachivayam

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

The imine base and Cu2+ precursors were combined using magnetic stirring to formulate the complexes. formation of was confirmed by electronic vibrational spectra, proton NMR, LC-mass spectrometry, computational studies, which also optimized final structure. complexes characterized susceptibility, molar conductivity, a variable temperature magnetometer, ESR spectroscopy. Cyclic voltammetry revealed electron transfer from Cu+ within complex. in vitro tumour activity evaluated on A431 cell line MTT assay. DFT studies validated structural stability base. antiferromagnetic behaviour observed at low temperatures suggests that these could be useful heavy materials. Due their properties, hold potential for use electroplating systems sensors. exhibited high efficacy line, aligning with clinical objectives. are represented as [MLR], where M is metal, L base, R = [C₆H₅COO] or [C₆H₄COO(NH₂)].

Language: Английский

Citations

0
Cytotoxicity, CT-DNA/BSA interaction and antioxidant activity of Ni(II), Cu(II) and Zn(II) complexes derived from a design nematogenic L-Alanyl-glycine based Schiff base ligand DOI

Jagritima Chetia,

Hunshisha Pyngrope,

Bandashisha Kharpan

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141858 - 141858

Published: Feb. 1, 2025

Language: Английский

Citations

0
3-Phenoxybenzaldehyde and Glycine-Derived Schiff base M(II) Complexes: Synthesis, molecular Modeling, spectroscopic Exploration, and antimicrobial evaluation DOI
R. Sankar,

T.M. Sharmila

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 162, P. 112253 - 112253

Published: March 1, 2024

Language: Английский

Citations

3
Laminated dihydrazone Zn(II) coordination polymer with prospects for sensory and multifunctional biomedical applications DOI
Olga Danilescu, П. Боурош, I. Bulhac

et al.

Polyhedron, Journal Year: 2024, Volume and Issue: 258, P. 117039 - 117039

Published: May 15, 2024

Language: Английский

Citations

2
Novel Copper (II) Complexes with Fluorine-Containing Reduced Schiff Base Ligands Showing Marked Cytotoxicity in the HepG2 Cancer Cell Line DOI Open Access

Bianka Oboňová,

Jindra Valentová,

Miroslava Litecká

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9166 - 9166

Published: Aug. 23, 2024

Several novel copper (II) complexes of reduced Schiff bases containing fluoride substituents were prepared and structurally characterized by single-crystal X-ray diffraction. The exhibited diverse structures, with the central atom in distorted tetrahedral geometry. biological effects products evaluated, specifically their cytotoxicity, antimicrobial, antiurease activities, as well affinity for albumin (BSA) DNA (ct-DNA). showed marked cytotoxic activities HepG2 hepatocellular carcinoma cell line, considerably higher than standard cisplatin. cytotoxicity depended significantly on substitution pattern. best activity was observed complex a trifluoromethyl group position 4 benzene ring-the dichloro[(±)-trans-

Language: Английский

Citations

2
Macrocyclic Schiff Base Complexes of Zn(II), Cu(II), Co(II), and Ni(II) Targeting Topoisomerase IIβ: Synthesis, Docking, and Evaluation as Potential Anticancer Agents DOI
Monika Yadav, Deepak Yadav,

Singh Dhanesh

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

ABSTRACT This study explores the potential of newly synthesized macrocyclic Schiff base metal complexes containing Zn(II), Cu(II), Ni(II) and Co(II) ions as Topoisomerase IIβ inhibitors. The were derived from condensation 2,3‐diamino‐5‐bromopyridine 2,5‐thiophenedicarboxaldehyde. Their formation was confirmed through various spectroscopic techniques. To gain insights into their structure biological activity, computational modeling employed. density functional theory (DFT) utilized to optimize molecular geometries complexes. Furthermore, in silico docking simulations with AutoDock Vina GOLD scoring function investigated binding interactions IIβ, an enzyme critical for cancer cell proliferation. combined analysis revealed promising affinities all complexes, complex 3b demonstrating most favorable interaction target having energy −8.56 kcal/mol. validate these predictions, cytotoxicity evaluated using established MTT assay. observed results complemented anticipated patterns, Cu(II) strongest inhibitory effect on cells IC 50 value 0.04 μM. Additionally, hemolytic human red blood (hRBCs) assessed determine biocompatibility. strong correlation between predicted interactions, cytotoxicity, minimal highlights particularly , leads developing novel anticancer drugs targeting IIβ. Future research will focus elucidating detailed mechanism action exploring broader pharmacological profile.

Language: Английский

Citations

1
mer-Bis(quinoline-2-carboxaldehyde 4-ethylthiosemicarbazonato)nickel(II) methanol 0.33-solvate 0.67-hydrate DOI Creative Commons

R. ADAM,

Natasha Ann Keasberry, M.H.S.A. Hamid

et al.

IUCrData, Journal Year: 2024, Volume and Issue: 9(4)

Published: April 26, 2024

In the title compound, [Ni(C 13 H N 4 S) 2 ]·0.33CH 3 OH·0.67H O, Ni II atom is coordinated by two tridentate quinoline-2-carboxaldehyde 4-ethylthiosemicarbazonate ligands in a distorted octahedral shape. At 100 K, crystal symmetry monoclinic (space group P 1 / n ). A mixture of water and methanol crystallizes with complex, one ethyl groups coordinating disordered over positions, an occupancy ratio 58:42. There intermolecular hydrogen bonding between solvent molecules amine thiolate ligands. No other significant interactions are present packing.

Language: Английский

Citations

0
Co, Cu, Ni, and Zn complexes of N-[(3-phenoxy phenyl)methylidene]-l-valine as α-glycosidase and α-amylase inhibitors: Synthesis, molecular docking & antimicrobial evaluation DOI
R. Sankar,

T.M. Sharmila

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108010 - 108010

Published: Nov. 29, 2024

Language: Английский

Citations

0