SWCNTs functionalized with gold nanoradiosensitizers as radiosensitizers for enhanced radiotherapy in breast cancer DOI Creative Commons
Ali Mohammadi, Negin Hashemi,

Zahra Asghariha

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Abstract Breast cancer is the most common and significant threat affecting women globally. Traditional methods have been widely used in treatment for many years. However, unavoidable side effects of these approaches are undeniable. Nanotechnology carbon nanotubes offer potential to improve traditional treatments by reducing enhancing efficacy. In this project, we investigated Single-Walled Carbon Nanotubes (SWCNTs) as advanced delivery systems chemotherapy agents directly within tumors, well their role substrates developing radiation sensitizers enhance efficacy therapy alone. To confirm successful formation nanoparticles, conducted various techniques such Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), UV-Visible spectroscopy X-Ray Diffraction (XRD) ensure accurate verification. evaluate cytotoxicity SWCNTs -Au-CUR performed MTT hemolysis assays. Subsequently, assessed effectiveness synthesized nanoparticles at different concentrations, with without aid X-ray, against cells. Observed results showed correct creation high on cancerous It also that presence X-rays amplified nanoparticle toxicity, increased ROS levels cells, resulted more effective induction DNA damage.

Язык: Английский

Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy DOI Creative Commons
Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 114 - 114

Опубликована: Янв. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Язык: Английский

Процитировано

7
Platinum nanoparticles-embedded single-walled carbon nanotubes as a new carrier for curcumin delivery and investigating its anticancer effect on cell line 4T1 DOI Creative Commons
Ali Mohammadi,

Fariba Bagheri,

Yasamin Abutalebi

и другие.

Heliyon, Год журнала: 2024, Номер 10(13), С. e33703 - e33703

Опубликована: Июнь 26, 2024

Cancer, a prevalent disease across various societies, presents significant challenge in treatment research. Studies show that combination therapies are one of the methods can help effective cancer. Chemotherapy and radiation therapy among main cancer treatments this project, for combined chemoradiotherapy treatment, carbon nanotubes were used as improved carriers chemotherapy tumors, well substrate preparation sensitizers local therapy. Following synthesis CNT-Platinum-Curcumin nanoparticles (CNT-Pt-CUR), series analyses conducted to verify successful production these nanoparticles. Techniques such Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS), UV–Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) employed. The characterization data revealed spherical shape Pt nanoparticle morphology with an 8.5 nm diameter on rod-shape CNT, observed through TEM. Furthermore, FTIR analysis confirmed loaded drug into nanoparticles, highlighting potential approach treatment. Then, hemolysis (3(-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests normal cells assess biocompatibility CNT-Pt-CUR It also explored anticancer efficacy at varying concentrations against cells, both without exposure X-rays. research demonstrated their impact cell viability. Specifically, breast exhibited heightened susceptibility toxicity when exposed Further is dose-dependent, modifying surface nanotube (CNT) CUR significantly reduced blood toxicity. Interestingly, was amplified presence X-rays, suggesting mechanisms DNA damage increased reactive oxygen species (ROS) levels within cells.

Язык: Английский

Процитировано

4
Innovative approaches in breast cancer therapy: repurposing nanocarriers for enhanced outcomes DOI

Sana Naaz Siddiqui,

Md. Faheem Haider, M.A. Rahman

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
SWCNTs Functionalized with Gold Nanoradiosensitizers as Radiosensitizers for Enhanced Radiotherapy in Breast Cancer DOI
Ali Mohammadi, Negin Hashemi,

Zahra Asghariha

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Chemotherapy and Radiotherapy of Single-Walled Carbon Nanotubes Containing Curcumin Functionalized with Platinum as Radiosensitizers DOI
Ali Mohammadi,

Fariba Bagheri,

Hajar Safari

и другие.

Опубликована: Янв. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Язык: Английский

Процитировано

0
SWCNTs functionalized with gold nanoradiosensitizers as radiosensitizers for enhanced radiotherapy in breast cancer DOI Creative Commons
Ali Mohammadi, Negin Hashemi,

Zahra Asghariha

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Abstract Breast cancer is the most common and significant threat affecting women globally. Traditional methods have been widely used in treatment for many years. However, unavoidable side effects of these approaches are undeniable. Nanotechnology carbon nanotubes offer potential to improve traditional treatments by reducing enhancing efficacy. In this project, we investigated Single-Walled Carbon Nanotubes (SWCNTs) as advanced delivery systems chemotherapy agents directly within tumors, well their role substrates developing radiation sensitizers enhance efficacy therapy alone. To confirm successful formation nanoparticles, conducted various techniques such Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), UV-Visible spectroscopy X-Ray Diffraction (XRD) ensure accurate verification. evaluate cytotoxicity SWCNTs -Au-CUR performed MTT hemolysis assays. Subsequently, assessed effectiveness synthesized nanoparticles at different concentrations, with without aid X-ray, against cells. Observed results showed correct creation high on cancerous It also that presence X-rays amplified nanoparticle toxicity, increased ROS levels cells, resulted more effective induction DNA damage.

Язык: Английский

Процитировано

0