Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Redox Biology, Год журнала: 2017, Номер 14, С. 450 - 464

Опубликована: Окт. 19, 2017

Oxidative stress is known to play an important role in the pathogenesis of a number diseases. In particular, it linked etiology Alzheimer's disease (AD), age-related neurodegenerative and most common cause dementia elderly. Histopathological hallmarks AD are intracellular neurofibrillary tangles extracellular formation senile plaques composed amyloid-beta peptide (Aβ) aggregated form along with metal-ions such as copper, iron or zinc. Redox active metal ions, for example can catalyze production Reactive Oxygen Species (ROS) when bound amyloid-β (Aβ). The ROS thus produced, particular hydroxyl radical which reactive one, may contribute oxidative damage on both Aβ itself surrounding molecule (proteins, lipids, …). This review highlights existing link between AD, consequences towards molecules terms damage. addition, implication ions their interaction redox properties leading discussed, vitro vivo oxidation peptide, at molecular level.

Язык: Английский

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Lipids and Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(4), С. 1505 - 1505

Опубликована: Фев. 22, 2020

Lipids, as the basic component of cell membranes, play an important role in human health well brain function. The is highly enriched lipids, and disruption lipid homeostasis related to neurologic disorders neurodegenerative diseases such Alzheimer’s disease (AD). Aging associated with changes composition. Alterations fatty acids at level rafts cerebral peroxidation were found early stage AD. Genetic environmental factors apolipoprotein transporter carrying status dietary content are Insight into connection between lipids AD crucial unraveling metabolic aspects this puzzling disease. Recent advances analytical methodology have led us gain in-depth understanding on lipids. As a result, lipidomics becoming hot topic investigation AD, order find biomarkers for prediction, diagnosis, prevention, ultimate goal discovering novel therapeutics.

Язык: Английский

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Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Ageing Research Reviews, Год журнала: 2021, Номер 70, С. 101397 - 101397

Опубликована: Июнь 30, 2021

An excess of saturated fatty acids and simple sugars in the diet is a known environmental risk factor Alzheimer's disease (AD) but holistic view interacting processes through which such may contribute to AD pathogenesis missing. We addressed this need extensive analysis published studies investigating effects western (WD) on development humans laboratory animals. reviewed WD-induced systemic alterations comprising metabolic changes, induction obesity adipose tissue inflammation, gut microbiota dysbiosis acceleration low-grade inflammation. Next we provide an overview evidence demonstrating that WD-associated drive impairment blood-brain barrier (BBB) neuroinflammation paralleled by accumulation toxic amyloid. Later these changes are followed dysfunction synaptic transmission, neurodegeneration finally memory cognitive impairment. conclude WD can trigger inflammaging, BBB induced inflammation play central role process. Moreover, concurrence Aβ dyshomeostasis, reciprocal interactions vicious cycle neurodegeneration, contradicts as primary AD. Given 2019 World Health Organization recommended focusing modifiable factors prevention, sequential, complex pathomechanisms initiated WD, lead from peripheral disturbances support future prevention strategies.

Язык: Английский

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Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2019, Номер 190, С. 104 - 114

Опубликована: Март 13, 2019

Alzheimer's disease (AD) is the most common form of dementia and it characterized by deposition amyloid-β (Aβ) plaques neurofibrillary tangles in brain. However, complete pathogenesis still unknown. High level serum cholesterol has been found to positively correlate with an increased risk some studies have reported a decreased prevalence AD patients taking cholesterol-lowering drugs. Years research shown strong correlation between blood hypercholesterolemia AD, however not able cross Blood Brain Barrier (BBB) into Cholesterol lowering therapies mixed results cognitive performance patients, raising questions whether brain metabolism should be studied separately from peripheral what their relationship is. Unlike cholesterol, oxidized metabolites known as oxysterols are BBB circulation vice-versa. The main present 24S-hydroxycholesterol 27-hydroxycholesterol. These catalysing enzymes altered brains there evidence indicating influence progression disease. This review gives broad perspective on for role pathological non-pathological conditions. Also, we propose valuable targets prevention alternative treatments.

Язык: Английский

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Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

Molecular Neurobiology, Год журнала: 2021, Номер 58(5), С. 2183 - 2201

Опубликована: Янв. 7, 2021

Язык: Английский

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An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Март 25, 2023

Abstract Alzheimer’s disease (AD) predominantly occurs as a late onset (LOAD) form involving neurodegeneration and cognitive decline with progressive memory loss. Risk factors that include aging promote accumulation of AD pathologies, such amyloid-beta tau aggregates, well inflammation oxidative stress. Homeostatic glial states regulate suppress pathology buildup; inflammatory exacerbate by releasing pro-inflammatory cytokines. Multiple stresses likely induce senescence, which could decrease supportive functions reinforce inflammation. In this perspective, we hypothesize first drives burden, whereafter putatively induces senescence in LOAD. We increasing particularly local senescent microglia accumulation, sustains perpetuating buildup spread aging, further senescence. predict also transitions individuals from healthy cognition into mild impairment LOAD diagnosis. These pathophysiological underpinnings may centrally contribute to onset, but require mechanistic investigation.

Язык: Английский

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Diet in the Prevention of Alzheimer’s Disease: Current Knowledge and Future Research Requirements

Nutrients, Год журнала: 2022, Номер 14(21), С. 4564 - 4564

Опубликована: Окт. 30, 2022

Alzheimer’s disease is a progressive brain that becoming major health problem in today’s world due to the aging population. Despite it being widely known diet has significant impact on prevention and progression of disease, literature data are still scarce controversial. The application principles rational nutrition for elderly suggested disease. should be rich neuroprotective nutrients, i.e., antioxidants, B vitamins, polyunsaturated fatty acids. Some studies suggest diets such as Mediterranean diet, DASH (Dietary Approaches Stop Hypertension) MIND (Mediterranean-DASH Intervention Neurodegenerative Delay) have beneficial effect risk developing

Язык: Английский

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Impact of high-fat diet on cognitive behavior and central and systemic inflammation with aging and sex differences in mice

Brain Behavior and Immunity, Год журнала: 2024, Номер 118, С. 334 - 354

Опубликована: Фев. 24, 2024

Язык: Английский

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Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications

Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 27, 2025

Alzheimer's disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to involvement of lipid dysregulation in development AD. Nevertheless, precise lipidomic landscape and mechanistic roles lipids pathology remain poorly understood. This review aims highlight significance lipidomics lipid-targeting approaches diagnosis We summarized connection between human brain AD at both genetic species levels. briefly introduced technologies discussed potential challenges areas future advancements field for research. To elucidate central role converging multiple pathological aspects AD, we reviewed current knowledge on interplay major features, including amyloid beta, tau, neuroinflammation. Finally, assessed progresses obstacles lipid-based therapeutics proposed strategies leveraging

Язык: Английский

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Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(15), С. 3810 - 3810

Опубликована: Авг. 4, 2019

Lipids in the brain are major components playing structural functions as well physiological roles nerve cells, such neural communication, neurogenesis, synaptic transmission, signal transduction, membrane compartmentalization, and regulation of gene expression. Determination lipid composition may provide not only essential information about normal functioning, but also changes with aging diseases. Indeed, deregulations specific classes homeostasis have been demonstrated neurodegenerative disorders Alzheimer’s disease (AD) Parkinson’s (PD). Furthermore, recent studies shown that microdomains, named rafts, change their correlation neuronal impairment. Lipid rafts key factors for signaling processes cellular responses. alteration these platforms correlate abnormal protein distribution aggregation, toxic cell signaling, other neuropathological events related This review highlights manner participate modulation to AD PD. Understanding characterizing contribute development novel diagnostic prognostic biomarkers routinely clinical practice.

Язык: Английский

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