Insulin Resistance and Oxidative Stress in the Brain: What’s New?

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(4), С. 874 - 874

Опубликована: Фев. 18, 2019

The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, mild cognitive impairment. Although some these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to neuronal redox imbalance oxidative damage. In this mini review, we provide schematic overview intracellular stress mitochondrial in IR brain. We highlight important correlations found so far brain stress, ceramide generation, β-amyloid accumulation, as well apoptosis conditions.

Язык: Английский

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Sources of free radicals and oxidative stress in the oral cavity

Archives of Oral Biology, Год журнала: 2018, Номер 92, С. 8 - 17

Опубликована: Май 1, 2018

Язык: Английский

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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Redox Biology, Год журнала: 2018, Номер 17, С. 259 - 273

Опубликована: Апрель 14, 2018

Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach determine if spontaneous nuclear DNA damage sufficient initiate mammals. Ercc1-/∆ mice with reduced expression ERCC1-XPF endonuclease have impaired capacity repair the genome. accumulated spontaneous, oxidative more rapidly than wild-type (WT) mice. As consequence, compared repair-competent animals. levels never exceeded that observed old WT Surprisingly, reactive oxygen species (ROS) were increased tissues an extent identical naturally-aged Increased enzymatic production ROS decreased antioxidants contributed elevation stress both aged Chronic treatment mitochondrial-targeted radical scavenger XJB-5–131 attenuated damage, pathology. Our findings indicate genotoxic arises, at least part, due mitochondrial-derived ROS, this drive cellular senescence, consequent physiological decline.

Язык: Английский

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The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases

Oxidative Medicine and Cellular Longevity, Год журнала: 2020, Номер 2020, С. 1 - 17

Опубликована: Окт. 17, 2020

Neurodegenerative diseases including Alzheimer’s disease and Parkinson’s are aging-associated with irreversible damage of brain tissue. Oxidative stress is commonly detected in neurodegenerative related to neuronal injury pathological progress. Exosome, one the extracellular vesicles, demonstrated carry microRNAs (miRNAs) build up a cell-cell communication neurons. Recent research has found that exosomal miRNAs regulate activity multiple physiological pathways, oxidative response, diseases. Here, we review role Firstly, explore relationship between Secondly, introduce characteristics exosomes roles exosome-related miRNAs. Thirdly, summarized crosstalk Fourthly, discuss potential be biomarker Finally, summarize advantages exosome-based delivery present situation on therapeutic miRNA. Our work aimed at probing reinforcing recognition pathomechanism providing basis for novel strategies clinical diagnosis treatment.

Язык: Английский

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Association of Oxidative Stress on Pregnancy

Oxidative Medicine and Cellular Longevity, Год журнала: 2020, Номер 2020, С. 1 - 12

Опубликована: Сен. 15, 2020

The pathophysiological mechanism underlying pregnancy complications such as congenital malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known. However, the negative impact of mother’s body oxidative imbalance on fetus and course gestation increasingly discussed. This article an integrative review some original studies papers effects stress adverse outcomes mainly birth defects in fetuses. A systematic search for English language articles published from 2010 until 2020 was made, using MEDLINE data. Additionally, we analyzed Cochrane Scopus databases, discussions with experts, a bibliography scientifically relevant valuable sources. main purposes are to assess contribution existing literature associations etiology abovementioned conditions identify information outline knowledge. Furthermore, authors aim find any gaps research, thereby providing grounds our own research. key terms were “oxidative pregnancy,” malformations,” outcomes.” Studies have confirmed that has significant involved pathomechanism outcomes.

Язык: Английский

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Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet‐Induced Insulin Resistance

Oxidative Medicine and Cellular Longevity, Год журнала: 2018, Номер 2018(1)

Опубликована: Янв. 1, 2018

Oxidative stress is a key pathogenic factor in both neurogenerative and metabolic diseases. However, its contribution the brain complications of insulin resistance still not well understood. Therefore, aim this study was evaluation redox homeostasis oxidative damage hypothalamus cerebral cortex insulin-resistant control rats. 16 male Wistar rats were divided into two equal groups (n = 8): high fat diet group (HFD). Prooxidant enzymes (xanthine oxidase NADPH oxidase); enzymatic nonenzymatic antioxidants [glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), superoxide dismutase-1 (SOD-1), uric acid (UA)]; products [advanced glycation end (AGE), 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG)] as total antioxidant capacity (TAC), oxidant status (TOS), index (OSI), ferric reducing ability sample (FRAP) evaluated serum/plasma HFD-fed The activity prooxidant significantly increased vs. Additionally, we have showed enhanced efficiency (↑CAT, ↑UA, ↑TAC, ↑FRAP) (↑GPx, ↑CAT, ↑SOD-1, All markers (AGE, 4-HNE, MDA, 8-OHdG, OSI) rats, while only 4-HNE MDA markedly higher HFD group. Summarizing, results our indicate an adaptive response to production free radicals under conditions. Despite increase antioxidative defense systems, mechanism does protect structures from damages. more susceptible caused by HFD.

Язык: Английский

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Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview

Mechanisms of Ageing and Development, Год журнала: 2022, Номер 206, С. 111707 - 111707

Опубликована: Июль 14, 2022

Язык: Английский

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Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?

International Journal of Molecular Sciences, Год журнала: 2017, Номер 18(10), С. 2205 - 2205

Опубликована: Окт. 20, 2017

Oxidative stress plays a crucial role in dementia pathogenesis; however, its impact on salivary secretion and qualities is still unknown. This study included 80 patients with moderate healthy age- sex-matched individuals. Salivary flow, antioxidants (salivary peroxidase, catalase, superoxide dismutase, uric acid total antioxidant capacity), oxidative damage products (advanced oxidation protein products, advanced glycation end (AGE), 8-isoprostanes, 8-hydroxy-2’-deoxyguanosine oxidant status) were estimated non-stimulated stimulated saliva, as well plasma erythrocytes. We show that the concentration/activity of major changes, level to DNA, proteins lipids increased compared controls. Non-stimulated secretions significantly reduced patients. The deterioration mini mental state examination (MMSE) score correlated AGE levels, which when considered receiver operating characteristic (ROC) analysis, suggests their potential non-invasive diagnosis dementia. In conclusion, associated disturbed redox homeostasis impaired secretory function glands. may be useful

Язык: Английский

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Neurodegeneration in ataxia‐telangiectasia: Multiple roles of ATM kinase in cellular homeostasis

Developmental Dynamics, Год журнала: 2017, Номер 247(1), С. 33 - 46

Опубликована: Май 23, 2017

Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes, immune deficiency, and increased sensitivity to ionizing radiation. A‐T attributed the deficiency of protein kinase coded ATM (ataxia‐telangiectasia mutated) gene. a sensor DNA double‐strand breaks (DSBs) signals cell cycle checkpoints repair machinery. phosphorylates numerous substrates activates many cell‐signaling pathways. There has been considerable debate about whether defective damage response causative neurological aspects disease. In proliferating cells, localized mainly in nucleus; however, postmitotic cells such as neurons, mostly cytoplasmic. Recent studies reveal an increasing number roles for cytoplasm, including activation oxidative stress. associates with organelles mitochondria peroxisomes, both sources reactive oxygen species (ROS), which have implicated neurodegenerative diseases aging. also associated synaptic vesicles role regulating cellular homeostasis autophagy. The cytoplasmic provide new perspective on process A‐T. This review will examine expanding relate these functions complex phenotype. Developmental Dynamics 247:33–46, 2018 . © 2017 Wiley Periodicals, Inc.

Язык: Английский

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Salivary Biomarkers of Oxidative Stress in Children with Chronic Kidney Disease

Journal of Clinical Medicine, Год журнала: 2018, Номер 7(8), С. 209 - 209

Опубликована: Авг. 10, 2018

There are still missing non-invasive biomarkers of chronic kidney disease (CKD) in children. Therefore, the aim study was to evaluate oxidative stress indicators non-stimulated (NWS) and stimulated saliva (SWS) CKD children (n = 25) healthy controls 25). Salivary antioxidants (catalase (CAT), peroxidase (Px), superoxide dismutase (SOD), uric acid (UA), reduced glutathione (GSH), albumin), redox status (total antioxidant capacity (TAC), total oxidant (TOS), index (OSI)), damage products (advanced glycation end (AGE), advanced oxidation protein (AOPP), malondialdehyde (MDA)) were evaluated. We have demonstrated significantly higher activity SWS GPx SOD, as well elevated concentrations UA albumin NWS vs. control group. TAC, TOS OSI only SWS, while (AGE, AOPP MDA) both ROC analysis showed a considerably high diagnostic value compared (AUC 0.92; 0.98). is responsible for disturbances salivary systems proteins lipids. can be potential biomarker

Язык: Английский

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