Advanced Functional Materials,
Год журнала:
2024,
Номер
34(45)
Опубликована: Авг. 21, 2024
Abstract
Metabolic‐associated
fatty
liver
disease
(MAFLD)
has
become
one
of
the
most
widespread
metabolic
diseases
nowadays,
while
no
definitive
agent
is
approved
for
practical
treatment.
Given
excessive
lipid
deposition
and
cellular
oxidative
stress
are
two
main
inducers
MAFLD,
developing
synergistic
therapeutic
agents
that
enhance
metabolism
antioxidative
ability
effective
routes
MAFLD
therapy.
Herein,
a
novel
kind
bio‐functional
carbon
dots
(MTCDs)
derived
from
metformin
tea
polyphenols
based
on
fused
pharmacophore
strategy
developed.
The
surface
MTCDs
retains
abundant
phenolic
hydroxyl
guanidine
groups,
which
designed
to
reduce
both
in
liver.
Moreover,
by
finely
controlling
charge,
exhibit
excellent
lysosome
targeting
functionality
with
favorable
biocompatibility
low
biotoxicity.
Mechanistical
studies
further
reveal
treatment
protects
lysosomes
damage
activates
hepatocyte
AMP‐activated
protein
kinase
signaling,
initiates
lipophagy
progress
accelerate
lipolysis
consumption.
Collectively,
these
propose
an
“two
birds
stone”
tool
therapy
suggest
viable
multi‐pharmacophore
development.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 16, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
series
of
diseases,
involving
excessive
lipid
deposition
in
the
and
often
accompanied
by
obesity,
diabetes,
dyslipidemia,
abnormal
blood
pressure,
other
metabolic
disorders.
In
order
to
more
accurately
reflect
its
pathogenesis,
an
international
consensus
renamed
NAFLD
2020
as
(dysfunction)
associated
with
(MAFLD).
The
changes
diet
lifestyle
are
recognized
non-drug
treatment
strategies;
however,
due
complex
pathogenesis
NAFLD,
current
drug
therapies
mainly
focused
on
pathogenic
factors,
key
links
related
disorders
targets.
There
still
lack
specific
drugs.
clinical
studies,
common
treatments
include
regulation
glucose
metabolism
protect
anti-inflammation.
based
enterohepatic
axis,
targeting
gut
microbiota,
gradually
emerging,
various
new
metabolism-regulating
drugs
also
under
development.
Therefore,
this
review
article
has
comprehensively
discussed
research
advancements
recent
years.
Annual Review of Physiology,
Год журнала:
2022,
Номер
84(1), С. 209 - 227
Опубликована: Фев. 10, 2022
Noncommunicable
diseases
are
chronic
that
contribute
to
death
worldwide,
but
these
can
be
prevented
and
mitigated
with
regular
exercise.
Exercise
activates
signaling
molecules
the
transcriptional
network
promote
physiological
adaptations,
such
as
fiber
type
transformation,
angiogenesis,
mitochondrial
biogenesis.
AMP-activated
protein
kinase
(AMPK)
is
a
master
regulator
senses
energy
state,
promotes
metabolism
for
glucose
fatty
acid
utilization,
mediates
beneficial
cellular
adaptations
in
many
vital
tissues
organs.
This
review
focuses
on
current,
integrative
understanding
of
role
exercise-induced
activation
AMPK
regulation
system
promotion
health
benefits.
Autophagy,
Год журнала:
2023,
Номер
20(2), С. 221 - 241
Опубликована: Сен. 12, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
one
of
the
most
common
chronic
diseases
with
a
global
rising
prevalence,
which
closely
associated
high-fat
diet
(HFD)
intake.
Macroautophagy/autophagy
an
evolutionarily
conserved
degradation
process
for
cytosolic
macromolecules
and
damaged
organelles.
The
potential
role
autophagy
in
hepatic
lipid
metabolism
has
been
recognized,
while
dysfunction
found
to
contribute
NAFLD.
Herein,
we
provide
overview
phases
regulatory
machinery,
current
understanding
its
protective
HFD-induced
We
also
discuss
genetic
pharmacological
interventions
that
may
help
elucidate
molecular
mechanisms
influence
future
therapeutic
direction
Aging,
Год журнала:
2022,
Номер
14(6), С. 2902 - 2919
Опубликована: Март 24, 2022
The
prevalence
of
type
2
diabetes
is
associated
with
inflammatory
bowels
diseases,
nonalcoholic
steatohepatitis
and
even
a
spectrum
cancer
such
as
colon
liver
cancer,
resulting
in
substantial
healthcare
burden
on
our
society.
Autophagy
key
regulator
metabolic
homeostasis
lipid
metabolism,
energy
management
the
balance
cellular
mineral
substances.
Mitophagy
selective
autophagy
for
clearing
damaged
mitochondria
dysfunctional
mitochondria.
A
myriad
evidence
has
demonstrated
major
role
mitophagy
regulation
homeostasis.
It
well
established
that
defective
been
linked
to
development
insulin
resistance.
Moreover,
resistance
further
progressed
various
diseases
nephropathy,
retinopathy
cardiovascular
diseases.
Concordantly,
restoration
will
be
reliable
therapeutic
target
diabetes.
Recently,
phytochemicals
have
proved
prevent
dysfunctions
β-cells
by
inductions
during
developments.
In
agreement
above
phenomenon,
inducers
should
warranted
potential
novel
agents
treating
This
review
focuses
relevant
pharmacological
basis
regulators
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
12(10), С. 3743 - 3782
Опубликована: Июнь 11, 2022
UNC-51-like
kinase
1
(ULK1),
as
a
serine/threonine
kinase,
is
an
autophagic
initiator
in
mammals
and
homologous
protein
of
autophagy
related
(Atg)
yeast
UNC-51
Caenorhabditis
elegans.
ULK1
well-known
for
activation,
which
evolutionarily
conserved
transport
indispensable
to
maintain
cell
homeostasis.
As
the
direct
target
energy
nutrition-sensing
may
contribute
distribution
utilization
cellular
resources
response
metabolism
closely
associated
with
multiple
pathophysiological
processes.
Moreover,
has
been
widely
reported
play
crucial
role
human
diseases,
including
cancer,
neurodegenerative
cardiovascular
disease,
infections,
subsequently
targeted
small-molecule
inhibitors
or
activators
are
also
demonstrated.
Interestingly,
non-autophagy
function
emerging,
indicating
that
non-autophagy-relevant
signaling
network
linked
diseases
under
some
specific
contexts.
Therefore,
this
review,
we
summarized
structure
functions
initiator,
focus
on
new
approaches,
further
elucidated
key
roles
non-autophagy.
Additionally,
discussed
relationships
between
well
illustrated
rapid
progress
better
understanding
discovery
more
candidate
drugs
targeting
ULK1,
will
provide
clue
novel
ULK1-targeted
therapeutics
future.
Abstract
Physical
exercise
is
effective
in
alleviating
mental
disorders
by
improving
synaptic
transmission;
however,
the
link
between
body
endurance
training
and
neural
adaptation
has
not
yet
been
completely
resolved.
In
this
study,
authors
investigated
role
of
RNA
N
6
‐methyladenosine
(m6A),
an
emerging
epigenetic
mechanism,
improved
resilience
against
chronic
restraint
stress.
A
combination
molecular,
behavioral,
vivo
recording
data
demonstrates
exercise‐mediated
restoration
m6A
mouse
medial
prefrontal
cortex,
whose
activity
potentiated
to
exert
anxiolytic
effects.
Furthermore,
it
revealed
that
hepatic
biosynthesis
one
methyl
donor
necessary
for
improve
brain
counteract
environmental
This
novel
liver‐brain
axis
provides
explanation
network
changes
upon
new
insights
into
diagnosis
treatment
anxiety
disorders.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(31), С. 11321 - 11340
Опубликована: Авг. 16, 2023
As
far
as
health
benefit
is
concerned,
dark
tea
one
of
the
best
beverages
in
world.
Theabrownins
are
major
ingredient
contributing
to
benefits
and
known
"the
soft
gold
tea."
A
growing
body
evidence
indicated
that
theabrownins
macromolecular
pigments
with
reddish-brown
color
mellow
taste,
mainly
derived
from
oxidative
polymerization
polyphenols.
main
active
ingredients
which
brings
multiple
health-promoting
effects
modulating
lipid
metabolism,
reducing
weight
gain,
attenuating
diabetes,
mitigating
NAFLD,
scavenging
ROS,
preventing
tumors.
More
importantly,
it's
their
substantial
generation
microbial
fermentation
endows
much
stronger
hypolipidemic
effect
compared
other
types
tea.
This
review
firstly
summarizes
most
recent
findings
on
preparation,
structural
characteristics,
theabrownins,
emphasizing
underlying
molecular
mechanism,
especially
different
mechanisms
behind
theabrownins-mediated
gut
microbiota
host's
benefits.
Furthermore,
this
points
out
limitations
current
research
potential
future
directions,
hoping
provide
updated
scientific
for
better
theoretical
industrial
utilization.
