The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2652 - 2652

Опубликована: Янв. 31, 2023

Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths in world. Metabolic reprogramming considered a new hallmark cancer, but it remains unclearly described HCC. The dysregulation PI3K/AKT/mTOR signaling pathway common HCC and is, therefore, topic further research concern developing novel target for liver cancer therapy. In this review, we illustrate mechanisms by which network accountable regulating cellular metabolism, including glucose lipid amino acid pyrimidine oxidative summarize ongoing clinical trials based on inhibition

Язык: Английский

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Possible Side Effects of Polyphenols and Their Interactions with Medicines

Molecules, Год журнала: 2023, Номер 28(6), С. 2536 - 2536

Опубликована: Март 10, 2023

Polyphenols are an important component of plant-derived food with a wide spectrum beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which used in the prevention and treatment diseases. Unfortunately, as any chemical substance, depending conditions, dose, interactions environment, it is possible for polyphenols also exert harmful effects. This review presents comprehensive current state knowledge negative impact health, describing side polyphenol intake, form supplements. The begins brief overview physiological role potential use disease prevention, followed by exerted particular situations. individual chapters discuss consequences polyphenols’ ability block iron uptake, some subpopulations can be harmful, well inhibition digestive enzymes, intestinal microbiota, polyphenolic compounds drugs, hormonal balance. Finally, prooxidative activity mutagenic, carcinogenic, genotoxic presented. According authors, there need raise public awareness about supplementation, case vulnerable subpopulations.

Язык: Английский

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Research progress of proanthocyanidins and anthocyanidins

Phytotherapy Research, Год журнала: 2023, Номер 37(6), С. 2552 - 2577

Опубликована: Апрель 29, 2023

Abstract Proanthocyanidins (PA) are polyphenol compounds that widely distributed in the bark, fruit core, skin, or seeds of various plants. Anthocyanidins water‐soluble natural pigments found They all flavonoids, a major coloring substance plants and fruits. In recent years, research into PA anthocyanins has become increasingly popular because their excellent anti‐oxidation, scavenging reactive oxygen free radicals other physical chemical activities, anti‐cancer, vision protection, aging prevention, skin beauty pharmacological, nutraceutical effects. Especially, systematic reviews meta‐analyses indicate value, safety, efficacy adjuvant therapy, management cardiometabolic disease. Here, we summarize progress from aspects structure, biosynthetic pathways, distribution, extraction separation, coloration, efficacy, potential. The comparison between them might provide reference for development efficient utilization. However, more large‐sample‐size randomized controlled trials high‐quality studies needed to firmly establish clinical efficacy.

Язык: Английский

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Polyphenols: Secondary Metabolites with a Biological Impression

Nutrients, Год журнала: 2024, Номер 16(15), С. 2550 - 2550

Опубликована: Авг. 3, 2024

Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.

Язык: Английский

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Phenolic-protein interactions in foods and post ingestion: Switches empowering health outcomes

Trends in Food Science & Technology, Год журнала: 2021, Номер 118, С. 71 - 86

Опубликована: Сен. 2, 2021

Язык: Английский

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Pharmacology and toxicology of tannins

Archives of Toxicology, Год журнала: 2022, Номер 96(5), С. 1257 - 1277

Опубликована: Фев. 23, 2022

Язык: Английский

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Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials

Antioxidants, Год журнала: 2023, Номер 12(5), С. 1004 - 1004

Опубликована: Апрель 26, 2023

Oligomeric Proanthocyanidins (OPCs), as a class of compounds widely found in plants, are particularly abundant grapes and blueberries. It is polymer comprising many different monomers, such catechins epicatechins. The monomers usually linked to each other by two types links, A-linkages (C-O-C) B-linkages (C-C), form the polymers. Numerous studies have shown that compared high polymeric procyanidins, OPCs exhibit antioxidant properties due presence multiple hydroxyl groups. This review describes molecular structure natural source OPCs, their general synthesis pathway capacity, potential applications, especially anti-inflammatory, anti-aging, cardiovascular disease prevention, antineoplastic functions. Currently, attracted much attention, being non-toxic antioxidants plant origin scavenge free radicals from human body. would provide some references for further research on biological functions application various fields.

Язык: Английский

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Protein and Peptide‐Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Авг. 3, 2023

Anthocyanin, a unique natural polyphenol, is abundant in plants and widely utilized biomedicine, cosmetics, the food industry due to its excellent antioxidant, anticancer, antiaging, antimicrobial, anti-inflammatory properties. However, degradation of anthocyanin an extreme environment, such as alkali pH, high temperatures, metal ions, limits physiochemical stabilities bioavailabilities. Encapsulation combining with biomaterials could efficiently stabilize for protection. Promisingly, or artificially designed proteins peptides favorable stabilities, biocapacity, wide sources are potential candidates anthocyanin. This review focuses on recent progress, strategies, perspectives protein peptide functionalization delivery, i.e., formulation technologies, physicochemical stability enhancement, cellular uptake, bioavailabilities, biological activities development. Interestingly, simplicity diversity structure, interaction mechanisms between be illustrated. work sheds light mechanism protein/peptide-anthocyanin nanoparticle construction expands applications nutrition biomedicine.

Язык: Английский

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Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

Pharmaceuticals, Год журнала: 2023, Номер 16(1), С. 101 - 101

Опубликована: Янв. 10, 2023

Polyphenols and their derivates, a kind of natural product distributed in herb plants, vegetables, fruits, are the most abundant antioxidants human diet have been found to display cancer-preventative effects several epidemiological studies. The scientific community has also validated anti-cancer bioactivities low toxicities polyphenolic compounds, including flavones, tannins, phenolic acids, anthocyanins, through vitro vivo However, stability, weak targeting ability, poor solubility, bioavailability pure agents significantly impaired treatment efficacy. Nowadays, nano-based technology applied surmount these restrictions maximize efficacy polyphenols. In this review, we summarize advantages related mechanisms polyphenols cancer treatment. Moreover, aiming at solubility vivo, delivery systems recent research developments highlighted. Herein, particular emphasis is mainly placed on widely used nanomaterials products, liposomes, micelles, nanogels. Finally, present an overview challenges future implementations compounds therapeutic field.

Язык: Английский

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Valorization of polyphenolic compounds from food industry by-products for application in polysaccharide-based nanoparticles

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Май 24, 2023

In the last decades, evidence has indicated beneficial properties of dietary polyphenols. vitro and in vivo studies support that regular intake these compounds may be a strategy to reduce risks some chronic non-communicable diseases. Despite their properties, they are poorly bioavailable compounds. Thus, main objective this review is explore how nanotechnology improves human health while reducing environmental impacts with sustainable use vegetable residues, from extraction development functional foods supplements. This extensive literature discusses different based on application stabilize polyphenolic maintain physical–chemical stability. Food industries commonly generate significant amount solid waste. Exploring bioactive waste been considered line emerging global sustainability needs. Nanotechnology can an efficient tool overcome challenge molecular instability, especially using polysaccharides such as pectin assembling material. Complex biomaterials extracted citrus apple peels (from juice industries) constitute promising wall material stabilizing chemically sensitive Pectin excellent biomaterial form nanostructures, it low toxicity, biocompatible, resistant enzymes. The potential polyphenols residues inclusion food supplements possible constitutes approach for effectively including diet. Extracting polyphenolics industrial feasible add value by-products, nature preserve

Язык: Английский

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