Abstract
Background
The
immune
system
is
closely
related
to
hypertension.
Hypertension
an
disorder
a
certain
extent,
and
inflammation
the
basis
of
abnormally
elevated
blood
pressure
(BP).
accumulation
T
cells
their
cytokines
can
increase
BP
end
organ
damage.
are
activated
by
antigen-presenting
innate
or
influence
high-sodium
diet,
self-environment,
gut
microbiota.
These
produce
inflammatory
factors
cytokines,
such
as
interleukin-17A
(IL-17A)
in
helper
17
cells,
causing
vascular
inflammation,
hypertension,
target
damage
Methods
In
this
article,
we
provide
insightful
review
research
progress
regarding
role
IL-17A
pathogenesis
hypertension
its
effects
on
different
organs
while
emphasizing
mediated
functions
kidneys,
brain,
intestines,
development
progression
Results
At
level,
involved
vessels,
interacting
with
multiple
signal
pathway.
Conclusions
findings
have
significant
implications
for
developing
future
immunomodulatory
therapies,
which
may
lead
potential
treatments
The
gut
microbiome
is
known
as
the
tenth
system
of
human
body
that
plays
a
vital
role
in
intersection
between
health
and
disease.
considerable
inter-individual
variability
microbiota
poses
both
challenges
great
prospects
promoting
precision
medicine
cardiovascular
diseases
(CVDs).
In
this
review,
based
on
development,
evolution,
influencing
factors
full
life
circle,
we
summarized
recent
advances
characteristic
alteration
CVDs
throughout
different
stages,
depicted
their
pathological
links
mechanism,
well
highlight
achievements
targeting
prevention,
diagnosis
treatment.
Personalized
strategies
could
be
tailored
according
to
characteristics
including
microbiota-blood
metabolites
combined
prediction
diagnosis,
dietary
interventions,
lifestyle
improvements,
probiotic
or
prebiotic
supplements.
However,
fulfill
promise
lifelong
health,
more
mechanism
studies
should
progress
from
correlation
causality
decipher
novel
mechanisms
linking
specific
microbes
CVDs.
It
also
promising
use
burgeoning
artificial
intelligence
machine
learning
target
for
developing
screening
new
therapeutic
interventions.
The Journal of Clinical Endocrinology & Metabolism,
Год журнала:
2024,
Номер
109(8), С. 2097 - 2105
Опубликована: Янв. 24, 2024
Abstract
Context
Type
2
diabetes
(T2D)
is
the
major
contributor
to
chronic
kidney
disease
and
end-stage
(ESKD).
The
influence
of
trimethylamine
N-oxide
(TMAO)
on
outcomes
in
T2D
remains
unclear.
Objective
To
examine
association
between
fasting
serum
TMAO
levels
adverse
patients
with
T2D.
Methods
Between
October
2016
June
2020,
were
recruited
monitored
every
3
months
until
December
2021.
Serum
assessed
using
liquid
chromatography-mass
spectrometry.
primary
doubling
creatinine
or
progression
ESKD
necessitating
dialysis;
secondary
outcome
was
a
rapid
30%
decline
estimated
glomerular
filtration
rate
within
years.
All-cause
mortality
also
evaluated.
Results
Among
440
enrolled
T2D,
those
highest
tertile
(≥0.88
μM)
older,
had
longer
duration,
elevated
blood
urea
nitrogen,
lower
rate.
Over
median
follow-up
period
4
years,
26
(5.9%)
level
ESKD.
After
propensity
score
weighting,
6.45-fold
increase
risk
5.86-fold
function
compared
lowest
tertile.
Additionally,
stepwise
associated
all-cause
mortality.
Conclusion
Patients
circulating
are
at
higher
creatinine,
progressing
ESKD,
potential
biomarker
for
Medicine,
Год журнала:
2024,
Номер
103(1), С. e36784 - e36784
Опубликована: Янв. 5, 2024
Background:
The
gut
microbiota-dependent
metabolite
trimethylamine
N-oxide
(TMAO)
has
recently
been
recognized
to
be
one
of
the
risk
factors
for
cardiovascular
disease
(CVD).
However,
there
is
a
scarcity
data
on
relationship
between
circulating
TMAO
levels
and
hypertension
in
patients
with
CVD.
Meta
analysis
dose-response
were
used
this
study
assess
Methods:
CNKI,
Wanfang
Database,
Pubmed,
Embase,
Cochrane
Library,
Web
Science
searched
up
June
01,
2023.
Meta-analysis
relative
from
prospective
cohort
studies
reporting
CVD
conducted.
Results:
Fifteen
total
15,498
included
present
meta-analysis.
Compared
lower
level,
higher
level
was
associated
(RR
=
1.14,95%CI
(1.08,
1.20)).
And
greater
hypertension.
revealed
linear
increased
by
1.014%
when
1
μ
mol/L.
Conclusion:
In
CVD,
significantly
related
every
mol/L
increase
levels.
Abstract
Background
The
immune
system
is
closely
related
to
hypertension.
Hypertension
an
disorder
a
certain
extent,
and
inflammation
the
basis
of
abnormally
elevated
blood
pressure
(BP).
accumulation
T
cells
their
cytokines
can
increase
BP
end
organ
damage.
are
activated
by
antigen-presenting
innate
or
influence
high-sodium
diet,
self-environment,
gut
microbiota.
These
produce
inflammatory
factors
cytokines,
such
as
interleukin-17A
(IL-17A)
in
helper
17
cells,
causing
vascular
inflammation,
hypertension,
target
damage
Methods
In
this
article,
we
provide
insightful
review
research
progress
regarding
role
IL-17A
pathogenesis
hypertension
its
effects
on
different
organs
while
emphasizing
mediated
functions
kidneys,
brain,
intestines,
development
progression
Results
At
level,
involved
vessels,
interacting
with
multiple
signal
pathway.
Conclusions
findings
have
significant
implications
for
developing
future
immunomodulatory
therapies,
which
may
lead
potential
treatments
