International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
265, С. 130961 - 130961
Опубликована: Март 18, 2024
Previous
studies
have
progressively
elucidated
the
involvement
of
E3
ubiquitin
(Ub)
ligases
in
regulating
lipid
metabolism.
Ubiquitination,
facilitated
by
Ub
ligases,
modifies
critical
enzymes
metabolism,
enabling
them
to
respond
specific
signals.
In
this
review,
we
aim
present
a
comprehensive
analysis
role
which
includes
synthesis
and
lipolysis,
their
influence
on
cellular
homeostasis
through
modulation
uptake
efflux.
Furthermore,
it
explores
how
ubiquitination
process
governs
degradation
or
activation
pivotal
enzymes,
thereby
metabolism
at
transcriptional
level.
Perturbations
been
implicated
various
diseases,
including
hepatic
disorders,
atherosclerosis,
diabetes,
cancer.
Therefore,
review
focuses
association
between
lipid-related
highlighting
critically
involved
catabolism,
regulators,
translocators,
transporters.
Overall,
aims
identify
gaps
current
knowledge,
highlight
areas
requiring
further
research,
offer
potential
targeted
therapeutic
approaches,
provide
outlook
clinical
conditions
associated
with
metabolic
diseases.
PubMed,
Год журнала:
2024,
Номер
16(1), С. 402 - 430
Опубликована: Янв. 5, 2024
The
global
prevalence
of
breast
cancer
necessitates
the
development
innovative
prognostic
markers
and
therapeutic
strategies.
This
study
investigated
implications
anoikis-related
long
non-coding
RNAs
(ARLs)
in
invasive
(IBC),
which
is
an
area
that
has
not
been
extensively
explored.
By
integrating
RNA
sequence
transcriptome
clinical
data
from
Cancer
Genome
Atlas
(TCGA)
database
employing
advanced
regression
analyses,
we
devised
a
novel
model
based
on
ARL
scores.
scores
correlated
with
diverse
clinicopathological
parameters,
cellular
pathways,
distinct
mutation
patterns,
immune
responses,
thereby
affecting
both
cell
infiltration
anticipated
responses
to
chemotherapy
immunotherapy.
Additionally,
overexpression
specific
lncRNA,
Redox Biology,
Год журнала:
2023,
Номер
68, С. 102959 - 102959
Опубликована: Ноя. 10, 2023
Colorectal
cancer
(CRC)
is
a
common
and
deadly
disease
of
the
digestive
system,
but
its
targeted
therapy
hampered
by
lack
reliable
specific
biomarkers.
Hence,
discovering
new
therapeutic
targets
agents
for
CRC
an
urgent
challenging
task.
Here
we
report
that
carnitine
palmitoyltransferase
1A
(CPT1A),
mitochondrial
enzyme
catalyzes
fatty
acid
oxidation
(FAO),
potential
target
treatment.
We
show
CPT1A
overexpressed
in
cells
inhibition
secolignan-type
compound,
2,6-dihydroxypeperomin
B
(DHP-B),
isolated
from
plant
Peperomia
dindygulensis,
suppresses
tumor
cell
growth
induces
apoptosis.
demonstrate
DHP-B
covalently
binds
to
Cys96
CPT1A,
blocks
FAO,
disrupts
CPT1A-VDAC1
interaction,
leading
increased
permeability
reduced
oxygen
consumption
energy
metabolism
cells.
also
reveal
expression
correlates
with
survival
tumor-bearing
animals
exhibits
anti-CRC
activity
vitro
vivo.
Our
study
uncovers
molecular
mechanism
as
novel
inhibitor
provides
rationale
preclinical
development
well
strategy
therapy.
The
extracellular
matrix
(ECM)
governs
a
wide
spectrum
of
cellular
fate
processes,
with
particular
emphasis
on
anoikis,
an
integrin-dependent
form
cell
death.
Currently,
anoikis
is
defined
as
intrinsic
apoptosis.
In
contrast
to
traditional
apoptosis
and
necroptosis,
integrin
correlates
ECM
signaling
intracellular
cascades,
describing
the
full
process
anoikis.
However,
frequently
overlooked
in
physiological
pathological
processes
well
vitro
research
models.
this
review,
we
summarized
role
spanning
embryonic
development,
organ
tissue
repair,
inflammatory
responses,
cardiovascular
diseases,
tumor
metastasis,
so
on.
Similarly,
realm
stem
focused
functional
evolution
cells,
offers
potential
solution
various
challenges,
including
culture
models,
therapy,
transplantation,
engineering
applications,
which
are
largely
based
regulation
by
More
importantly,
regulatory
mechanisms
molecular
will
provide
new
strategies
for
therapeutic
interventions
(drug
therapy
cell-based
therapy)
disease.
summary,
review
provides
systematic
elaboration
thus
shedding
light
its
future
research.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 29, 2025
The
ubiquitin-proteasome
system
(UPS)
is
one
of
the
main
degradation
systems
within
cells,
catalyzing
tagging
proteins
for
by
ubiquitin
molecules,
which
are
then
recognized
and
degraded
proteasome.
Lipid
metabolism
plays
a
crucial
role
in
cellular
energy
closely
associated
with
occurrence
development
cancers.
Recent
research
indicates
that
cancer
lipid
regulated
intracellular
proteins,
including
ubiquitination
modifications.
This
review
will
explore
regulating
metabolism,
summarize
latest
progress,
propose
potential
therapeutic
strategies.
International Journal of Cancer,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Gastrointestinal
cancers
including
esophageal
squamous
cell
carcinoma
(ESCC),
gastric
cancer
(GC),
and
colorectal
(CRC)
are
common
highly
lethal
types
of
worldwide.
Metabolic
reprogramming
plays
a
critical
role
in
progression
involves
metabolic
processes
such
as
glucose
lipid
metabolism.
Fatty
acid
oxidation
(FAO)
has
profound
impact
on
cancer,
with
many
genes
cytokines
influencing
initiation,
development,
metastasis,
resistance
by
regulating
FAO.
Additionally,
FAO
further
promotes
affecting
the
tumor
microenvironment
(TME).
The
gastrointestinal
garnered
increasing
attention,
related
anticancer
drugs
currently
being
developed.
