Biochemistry (Moscow),
Год журнала:
2024,
Номер
89(6), С. 1014 - 1023
Опубликована: Июнь 1, 2024
Damages
of
various
origin
accumulated
in
the
genomic
DNA
can
lead
to
breach
genome
stability,
and
are
considered
be
one
main
factors
involved
cellular
senescence.
repair
systems
mammalian
cells
ensure
effective
damage
removal
structure,
therefore,
activity
these
is
expected
correlated
with
high
maximum
lifespan
observed
long-lived
mammals.
This
review
discusses
current
results
studies
focused
on
determination
system
investigation
properties
its
key
regulatory
proteins
rodents
bats.
Based
works
discussed
review,
it
could
concluded
that
bats
general
demonstrate
efficiency
functioning
regulation
systems.
Nevertheless,
a
number
questions
around
study
remain
poorly
understood,
answers
which
open
up
new
avenues
for
further
research.
Frontiers in Endocrinology,
Год журнала:
2021,
Номер
12
Опубликована: Июль 6, 2021
Bone
regeneration
is
a
complex
process
that
requires
the
coordination
of
osteogenesis
and
osteoclastogenesis.
The
balance
between
adipogenesis
bone
marrow
mesenchymal
stem
cells
(BMSCs)
plays
major
role
in
formation.
Recently,
intercellular
communication
surrounding
has
been
gradually
recognized,
macrophages
on
surface
have
proven
to
regulate
metabolism.
However,
underlying
mechanisms
not
fully
elucidated.
Recent
studies
indicated
exosomes
are
vital
messengers
for
cell-cell
various
biological
processes.
In
this
experiment,
we
found
derived
from
M2
(M2D-Exos)
could
inhibit
promote
BMSCs.
M2D-Exo
intervention
increased
expression
miR-690,
IRS-1,
TAZ
Additionally,
miR-690
knockdown
with
inhibitor
partially
counteracted
effect
M2D-Exos
BMSC
differentiation
upregulation
IRS-1
expression.
Taken
together,
results
our
study
indicate
isolated
facilitate
reduce
through
miR-690/IRS-1/TAZ
axis
might
be
therapeutic
tool
loss
diseases.
Pathogens and Immunity,
Год журнала:
2020,
Номер
5(1), С. 143 - 143
Опубликована: Июнь 17, 2020
People
with
HIV
(PWH)
experience
accentuated
biological
aging,
as
defined
by
markers
of
inflammation,
immune
dysfunction,
and
the
epigenetic
clock.
They
also
have
an
elevated
risk
multiple
age-associated
comorbidities.
To
discuss
current
knowledge,
research
gaps,
priorities
in
aging
age-related
comorbidities
treated
infection,
NIH
program
staff
organized
a
workshop
held
Bethesda,
Maryland
September
2019.
This
review
article
describes
highlights
discussions
led
Pathogenesis/Basic
Science
Research
working
group
that
focused
on
three
high
priority
topics:
immunopathogenesis;
microbiome/virome;
senescence.
We
summarize
knowledge
these
fields
describe
key
questions
for
pathogenesis
PWH.
Understanding
drivers
mechanisms
underlying
is
will
help
identify
potential
therapeutic
targets
to
improve
healthspan
older
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(11), С. 6031 - 6031
Опубликована: Май 27, 2022
Plant
lignans
exhibit
a
wide
range
of
biological
activities,
which
makes
them
the
research
objects
potential
use
as
therapeutic
agents.
They
provide
diverse
naturally-occurring
pharmacophores
and
are
available
for
production
by
chemical
synthesis.
A
large
amount
accumulated
data
indicates
that
different
structural
groups
apt
to
demonstrate
both
anti-inflammatory
antioxidant
effects,
in
many
cases,
simultaneously.
In
this
review,
we
summarize
comprehensive
knowledge
about
lignan
bioactive
agent
disorders
associated
with
oxidative
stress
inflammation,
pharmacological
effects
vitro
vivo,
molecular
mechanisms
underlying
these
synthesis
approaches.
This
article
provides
an
up-to-date
overview
current
area,
PubMed,
Scopus,
Web
Science
databases,
screened
from
2000
2022.
Natural Products and Bioprospecting,
Год журнала:
2024,
Номер
14(1)
Опубликована: Авг. 20, 2024
Arctium
lappa,
widely
recognized
as
burdock,
is
a
perennial
plant
that
employed
in
the
realm
of
traditional
Chinese
medicine
for
wide
range
medicinal
applications.
The
herb
rich
bioactive
metabolites
with
therapeutic
potential,
encompassing
polyphenolic
antioxidants
its
leaves,
and
flavonoids
fructo-oligosaccharides
underground
parts.
Nutraceuticals
originating
from
botanical
sources
such
lappa
provide
supplementary
health
advantages
alongside
their
nutritional
content
have
demonstrated
effectiveness
prevention
management
specific
ailments.
utilization
root
extract
has
exhibited
encouraging
outcomes
addressing
hepatotoxicity
induced
by
cadmium,
lead,
chromium,
acetaminophen,
ameliorating
liver
damage
oxidative
stress.
Additionally,
displays
properties
antidiabetic,
hypolipidemic,
aphrodisiac,
anti-rheumatic,
anti-Alzheimer,
various
other
pharmacological
actions.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 4, 2024
Traumatic
brain
injury
(TBI)
leads
to
damage,
comprising
both
immediate
primary
damage
and
a
subsequent
cascade
of
secondary
mechanisms.
The
results
in
localized
while
the
initiates
inflammatory
responses,
followed
by
disruption
blood-brain
barrier,
infiltration
peripheral
blood
cells,
edema,
release
various
immune
mediators,
including
chemotactic
factors
interleukins.
TBI
disrupts
molecular
signaling,
cell
structures,
functions.
In
addition
physical
tissue
such
as
axonal
injuries,
contusions,
haemorrhages,
interferes
with
functioning,
impacting
cognition,
decision-making,
memory,
attention,
speech
capabilities.
Despite
deep
understanding
pathophysiology
TBI,
an
intensive
effort
evaluate
underlying
mechanisms
effective
therapeutic
interventions
is
imperative
manage
repercussions
TBI.
Studies
have
commenced
explore
potential
employing
natural
compounds
for
These
are
characterized
their
low
toxicity
limited
interactions
conventional
drugs.
Moreover,
many
demonstrate
capacity
target
aspects
process.
While
our
there
urgent
need
mitigate
its
consequences.
Here,
we
aimed
summarize
mechanism
action
role
phytochemicals
against
progression.
This
review
discusses
implications
phytonutrients
addresses
consequences
addition,
highlighted
roles
emerging
promising
candidates
intervention
highlights
neuroprotective
mechanistic
approach.
Furthermore,
efforts
focused
on
mechanisms,
providing
better
therapeutics.
Marine Drugs,
Год журнала:
2022,
Номер
20(8), С. 473 - 473
Опубликована: Июль 25, 2022
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
one
of
the
most
aggressive
types
cancer
and
exhibits
a
devastating
5-year
survival
rate.
The
recent
procedure
for
treatment
PDAC
combination
several
conventional
chemotherapeutic
agents,
termed
FOLFIRINOX,
that
includes
irinotecan,
leucovorin,
oxaliplatin,
5-fluorouracil
(5-FU).
However,
ongoing
using
these
agents
challenging
due
to
their
severe
side
effects
limitations
on
range
patients
available
PDAC.
Therefore,
safer
more
innovative
anticancer
must
be
developed.
anticarcinoma
activity
matairesinol
can
extracted
from
seagrass
has
been
reported
in
various
cancer,
including
prostate,
breast,
cervical,
pancreatic
cancer.
molecular
mechanism
effective
against
remains
unclear.
In
present
study,
we
confirmed
inhibition
cell
proliferation
progression
induced
by
representative
human
lines
(MIA
PaCa-2
PANC-1).
Additionally,
triggers
apoptosis
causes
mitochondrial
impairment
as
evidenced
depolarization
membrane,
disruption
calcium,
suppression
migration
related
intracellular
signaling
pathways.
Finally,
exerts
synergistic
effect
with
5-FU,
standard
agent
These
results
demonstrate
therapeutic
potential
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(22), С. 5967 - 5983
Опубликована: Янв. 24, 2022
Inflammation
is
a
major
factor
affecting
human
health.
Nuclear
factor-kappa
B
(NF-κB)
plays
vital
role
in
the
development
of
inflammation,
and
promoters
most
inflammatory
cytokine
genes
have
NF-κB-binding
sites.
Targeting
NF-κB
could
be
an
exciting
route
for
prevention
treatment
diseases.
As
important
constituents
natural
plants,
lignans
are
proved
to
numerous
biological
functions.
There
growing
pieces
evidence
demonstrate
that
potential
anti-inflammatory
activities.
In
this
work,
type,
structure
source
influence
on
mitigating
inflammation
systematically
summarized.
This
review
focuses
targeting
signaling
pathway
response
by
different
their
molecular
mechanisms.
Lignans
also
regulate
gut
microflora
change
microbial
metabolites,
which
exert
novel
prevent
activation.
Taken
together,
target
with
various
mechanisms
inhibit
expressions
response.
It
will
provide
scientific
theoretical
basis
further
research
effects
functional
foods.
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 514 - 514
Опубликована: Апрель 25, 2024
Sesame
seeds
are
important
resources
for
relieving
oxidation
stress-related
diseases.
Although
a
significant
variation
in
seeds’
antioxidant
capability
is
observed,
the
underlying
biochemical
and
molecular
basis
remains
elusive.
Thus,
this
study
aimed
to
reveal
major
seed
components
key
mechanisms
that
drive
variability
of
activity
(AOA)
using
panel
400
sesame
accessions.
The
AOA,
total
flavonoid,
phenolic
contents
varied
from
2.03
78.5%,
0.072
3.104
mg
CAE/g,
2.717
21.98
GAE/g,
respectively.
Analyses
revealed
flavonoids
acids
main
contributors
AOA
variation,
irrespective
coat
color.
LC-MS-based
polyphenol
profiling
high
(HA)
low
(LA)
uncovered
320
differentially
accumulated
compounds
(DAPs),
including
311
up-regulated
HA
seeds.
Tricin,
persicoside,
5,7,4′,5′-tetrahydro-3′,6-dimethoxyflavone,
8-methoxyapigenin,
6,7,8-tetrahydroxy-5-methoxyflavone
were
top
five
HA.
Comparative
transcriptome
analysis
at
three
developmental
stages
identified
627~2357
DEGs
unveiled
differential
regulation
flavonoid
biosynthesis,
phenylpropanoid
stilbene
biosynthesis
capacity
variation.
Major
regulated
structural
genes
transcription
factors
identified.
SINPZ0000571
(MYB),
SINPZ0401118
(NAC),
SINPZ0500871
(C3H)
most
highly
induced
TFs
Our
findings
may
enhance
quality
breeding.
Frontiers in Pharmacology,
Год журнала:
2020,
Номер
11
Опубликована: Дек. 8, 2020
Cardiovascular
disease
(CVD)
remains
the
leading
cause
of
morbidity
and
mortality
worldwide.
Atherosclerosis
(AS)
is
a
major
CVD.
Oxidative
stress,
endothelial
dysfunction,
inflammation
are
key
factors
involved
in
development
progression
AS.
Exosomes
nano-sized
vesicles
secreted
into
extracellular
space
by
most
types
cells,
ideal
substances
for
transmission
integration
signals
between
cells.
Cells
can
selectively
encapsulate
biologically
active
substances,
such
as
lipids,
proteins
RNA
exosomes
act
through
paracrine
mechanisms.
Non-coding
RNAs
(ncRNAs)
important
communication
They
reach
recipient
cells
exosomes,
causing
phenotypic
changes
playing
molecular
regulatory
role
cell
function.
Elucidating
their
mechanisms
help
identify
therapeutic
targets
or
strategies
Coronary
artery
(CAD)
Here,
we
review
mechanism
exosomal
ncRNAs
pathophysiology
CAD,
well
potential
contribution
ncRNA
to
diagnosis
treatment
CAD.