Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(10), С. 2615 - 2636
Опубликована: Дек. 5, 2023
Язык: Английский
Antioxidants, Год журнала: 2023, Номер 12(6), С. 1218 - 1218
Опубликована: Июнь 5, 2023
Ferroptosis, a recently identified form of regulated cell death characterized by the iron-dependent accumulation lethal lipid peroxidation, has gained increasing attention in cancer therapy. Ferroptosis suppressor protein 1 (FSP1), an NAD(P)H-ubiquinone oxidoreductase that reduces ubiquinone to ubiquinol, emerged as critical player regulation ferroptosis. FSP1 operates independently canonical system xc–/glutathione peroxidase 4 pathway, making it promising target for inducing ferroptosis cells and overcoming resistance. This review provides comprehensive overview ferroptosis, emphasizing importance modulation its potential therapeutic treatment. We also discuss recent progress developing inhibitors their implications Despite challenges associated with targeting FSP1, advances this field may provide strong foundation innovative effective treatments other diseases.
Язык: Английский
Процитировано
23
APOPTOSIS, Год журнала: 2024, Номер 29(7-8), С. 1019 - 1037
Опубликована: Апрель 14, 2024
Язык: Английский
Процитировано
14
Metabolism, Год журнала: 2024, Номер 157, С. 155953 - 155953
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
13
Redox Biology, Год журнала: 2024, Номер 75, С. 103259 - 103259
Опубликована: Июнь 27, 2024
Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox system, encompassing pro-oxidative proteins and antioxidative proteins. These undergo precise control through diverse post-translational modifications, including ubiquitination, phosphorylation, acetylation, O-GlcNAcylation, SUMOylation, methylation, N-myristoylation, palmitoylation, modification. modifications play pivotal roles in regulating protein stability, activity, localization, interactions, ultimately influencing both the buildup iron lipid peroxidation. In mammalian cells, regulators ferroptosis typically degradation via two principal pathways: ubiquitin-proteasome which handles majority degradation, autophagy, primarily targeting long-lived or aggregated This comprehensive review aims to summarize recent advances modification linked ferroptosis. It also discusses strategies for modulating systems, providing new insights into potential therapeutic applications cancer non-neoplastic diseases.
Язык: Английский
Процитировано
13
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Фев. 22, 2024
Abstract Despite recent advances in science and medical technology, pancreatic cancer remains associated with high mortality rates due to aggressive growth no early clinical sign as well the unique resistance anti-cancer chemotherapy. Current numerous investigations have suggested that ferroptosis, which is a programed cell death driven by lipid oxidation, an attractive therapeutic different tumor types including cancer. Here, we first demonstrated linoleic acid (LA) α-linolenic (αLA) induced necroptotic morphological change MIA-Paca2 Suit 2 lines. LA αLA increased peroxidation phosphorylation of RIP3 MLKL cancers, were negated ferroptosis inhibitor, ferrostatin-1, restoring back BSA control levels. Similarly, intraperitoneal administration suppresses subcutaneously transplanted Suit-2 cells ameliorated decreased survival rate bearing mice, while co-administration ferrostatin-1 effect. We also partially showed ferroptotic effects on gemcitabine-resistant-PK cells, although its effect was exerted late compared treatment normal-PK cells. In addition, trial validate importance double bonds PUFAs revealed AA EPA had marked but DHA mild suppression proliferation. Furthermore, other lines sensitivity PUFA-induced ferroptosis; e.g., colorectal adenocarcinoma, or did not. Collectively, these data suggest can potential exert via both normal gemcitabine-resistant
Язык: Английский
Процитировано
11
Functional & Integrative Genomics, Год журнала: 2024, Номер 24(1)
Опубликована: Фев. 1, 2024
Abstract Hepatocellular carcinoma (HCC) is a common malignant tumor with high recurrence rate and poor prognosis. Long intergenic nonprotein coding RNA 942 (LINC00942) reported to be related ferroptosis the immune response in HCC serves as an oncogene various cancers. This research aimed explore contribution of LINC00942 progression. Functional assays were used evaluate functional role vitro vivo. Mechanistic conducted assess association insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) solute carrier family 7 member 11 (SLC7A11) regulatory pattern cells. was found exhibit upregulation tissue facilitated cell proliferation, suppressed ferroptosis, converted naive CD4 + T cells inducible Treg (iTreg) by regulating SLC7A11. Furthermore, SLC7A11 expression positively modulated IGF2BP3 shared RNA-binding (RBP) for The between 3′ untranslated region verified, recruit promote stability m6A-dependent manner. Moreover, mouse proliferation inhibited, number FOXP3 CD25 increased, while enhanced after knockdown suppresses induces immunosuppression recruiting enhance stability, which may provide novel therapeutic targets HCC.
Язык: Английский
Процитировано
10
International Journal of Biological Sciences, Год журнала: 2024, Номер 20(9), С. 3621 - 3637
Опубликована: Янв. 1, 2024
Ferroptosis, an emerging type of programmed cell death, is initiated by iron-dependent and excessive ROS-mediated lipid peroxidation, which eventually leads to plasma membrane rupture death. Many canonical signalling pathways biological processes are involved in ferroptosis. Furthermore, cancer cells more susceptible ferroptosis due the high load ROS unique metabolic characteristics, including iron requirements. Recent investigations have revealed that plays a crucial role progression tumours, especially HCC. Specifically, induction can not only inhibit growth hepatoma cells, thereby reversing tumorigenesis, but also improves efficacy immunotherapy enhances antitumour immune response. Therefore, triggering has become new therapeutic strategy for therapy. In this review, we summarize characteristics based on its underlying mechanism HCC provide possible applications.
Язык: Английский
Процитировано
10
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Abstract Recipients often suffer from hyperlactatemia during liver transplantation (LT), but whether exacerbates hepatic ischemia‐reperfusion injury (IRI) after donor implantation remains unclear. Here, the role of in IRI is explored. In this work, found to exacerbate ferroptosis IRI. Lactate‐primed lysine acetyltransferase 8 (KAT8) determined directly lactylate mitochondrial phosphoenolpyruvate carboxykinase 2 (PCK2) at Lys100 and augments PCK2 kinase activity. By using gene‐edited mice, evidence indicating that generated. Mechanistically, acts as a critical inducer by competitively inhibiting Parkin‐mediated polyubiquitination 3‐oxoacyl‐ACP synthase (OXSM), thereby leading metabolic remodeling fatty acid synthesis (mtFAS) potentiation oxidative phosphorylation tricarboxylic cycle. More importantly, targeting demonstrated markedly ameliorate hyperlactatemia‐mediated Collectively, findings support use therapeutics suppress patients with LT.
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2023, Номер 319, С. 117282 - 117282
Опубликована: Окт. 5, 2023
Язык: Английский
Процитировано
22
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Май 23, 2024
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional RNA, play crucial regulatory roles in variety biological processes. this manuscript, we review lncRNAs key aspects summarize research progress on ferroptosis-related
Язык: Английский
Процитировано
7