Programmed cell death in hepatocellular carcinoma: mechanisms and therapeutic prospects

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Авг. 8, 2024

Hepatocellular Carcinoma (HCC), the most common primary liver cancer, ranks as third cause of cancer-related deaths globally. A deeper understanding cell death mechanisms in HCC is essential for developing more effective treatment strategies. This review explores programmed (PCD) pathways involved HCC, including apoptosis, necroptosis, pyroptosis, ferroptosis, and immunogenic (ICD). These trigger specific cascades that influence development progression HCC. Although multiple PCD are shared cellular factors suggest a possible interplay between different forms death. However, exact roles which pathway plays major role remain unclear. also highlights how disruptions related to drug resistance cancer therapy, promoting combined approach induction anti-tumor enhance therapeutic efficacy. Further research required unravel complex modalities may lead innovative breakthroughs.

Язык: Английский

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Crosstalk between m6A modification and non-coding RNAs in HCC

Cellular Signalling, Год журнала: 2024, Номер 117, С. 111076 - 111076

Опубликована: Фев. 2, 2024

Язык: Английский

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Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Сен. 15, 2023

Abstract Radiotherapy is often used to treat various types of cancers, but radioresistance greatly limits the clinical efficiency. Recent studies have shown that radiotherapy can lead ferroptotic cancer cell deaths. Ferroptosis a new type programmed death caused by excessive lipid peroxidation. The induction ferroptosis provides potential therapeutic strategy for radioresistance. As most common post-transcriptional modification mRNA, m 6 A methylation widely involved in regulation physiopathological processes regulating RNA function. Dynamic controlled regulatory factors also affects susceptibility cells ferroptosis, thereby determining radiosensitivity tumor radiotherapy. In this review, we summarize mechanism and significance induced analyze characteristics on discuss possibility radiosensitization enhancing A-mediated ferroptosis. Clarifying its response will help us identify novel targets improve efficacy reduce or overcome

Язык: Английский

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Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4‐xCT pathway

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(8)

Опубликована: Апрель 1, 2024

Abstract Management of hepatocellular carcinoma (HCC) remains challenging due to population growth, frequent recurrence and drug resistance. Targeting genes involved with the ferroptosis is a promising alternative treatment strategy for HCC. The present study aimed investigate effect dihydroartemisinin (DHA) against HCC explore underlying mechanisms. effects DHA on induction were investigated measurement malondialdehyde concentrations, oxidised C11 BODIPY 581/591 staining, as well subcutaneous xenograft experiments. Activated transcription factor 4 (ATF4) solute carrier family 7 member 11 (SLC7A11 or xCT) overexpressed lentiviruses verify target DHA. Here, we confirmed anticancer in inducing related ATF4. High expression ATF4 worse clinicopathological prognosis Mechanistically, inhibited ATF4, thereby promoting lipid peroxidation cells. Overexpression rescued DHA‐induced ferroptosis. Moreover, could directly bound SLC7A11 promoter increase its transcription. In addition, enhances chemosensitivity sorafenib vivo vitro. These findings confirm that induces via inhibiting ATF4‐xCT pathway, providing new options

Язык: Английский

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Ferroptosis: a new promising target for hepatocellular carcinoma therapy

Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(10), С. 2615 - 2636

Опубликована: Дек. 5, 2023

Язык: Английский

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