Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6518 - 6518

Опубликована: Март 30, 2023

Alzheimer’s disease is one of the most commonly diagnosed cases senile dementia in world. It an incurable process, often leading to death. This multifactorial, and factor this inflammation. Numerous mediators secreted by inflammatory cells can cause neuronal degeneration. Neuritis may coexist with other mechanisms disease, contributing progression, also directly underlie AD. Although much has been established about processes pathogenesis AD, many aspects remain unexplained. The work devoted particular pathomechanism inflammation its role diagnosis treatment. An in-depth detailed understanding neuroinflammation help development diagnostic methods for early contribute new therapeutic strategies disease.

Язык: Английский

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Oxidative stress in diabetes mellitus and its complications: From pathophysiology to therapeutic strategies

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Oxidative stress due to aberrant metabolism is considered as a crucial contributor diabetes and its complications. Hyperglycemia hyperlipemia boost excessive reactive oxygen species generation by elevated mitochondrial respiration, increased nicotinamide adenine dinucleotide phosphate oxidase activity, enhanced pro-oxidative processes, including protein kinase C pathways, hexosamine, polyol, advanced glycation endproducts, which exacerbate oxidative stress. plays significant role in the onset of associated complications impairing insulin production, increasing resistance, maintaining hyperglycemic memory, inducing systemic inflammation. A more profound comprehension molecular processes that link new preventive therapeutic strategies. Therefore, this review discusses mechanisms underlying how contributes mellitus We also summarize current approaches for prevention treatment targeting pathways diabetes.

Язык: Английский

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Autophagy-lysosomal pathway impairment and cathepsin dysregulation in Alzheimer’s disease

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Окт. 31, 2024

Alzheimer's disease (AD) is characterized by neuronal loss, attributed to amyloid-beta (Aβ) aggregation and accumulation. The autophagy-lysosomal pathway, including cathepsins B D, crucial for protein degradation clearance, but it impaired in some diseases. This review summarizes current knowledge on the dysregulation of this pathway AD. Accumulating evidence suggests that Aβ overload impairs function cathepsin activity, exacerbating accumulation neurodegeneration. However, precise mechanisms underlying these interactions remain elusive. Despite challenges, targeting lysosomal emerges as a promising therapeutic strategy, comprehensive understanding system essential develop effective interventions

Язык: Английский

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Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Alzheimer's disease (AD) presents a significant challenge to global healthcare systems, with an exacerbation by aging population. Although the plethora of hypotheses are proposed elucidate underlying mechanisms AD, from amyloid-beta (Aβ) accumulation and Tau protein aggregation neuroinflammation, comprehensive understanding its pathogenesis remains elusive. Recent research has highlighted critical role calcium (Ca This review aims consolidate current Ca The focuses on three principal concepts. First, indispensable

Язык: Английский

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The multiple biological activities of hyperoside: from molecular mechanisms to therapeutic perspectives in neoplastic and non-neoplastic diseases

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

In recent years, hyperoside (quercetin 3-O-β-D-galactopyranoside) has garnered significant attention due to its diverse biological effects, which include vasoprotective, antioxidant, anti-inflammatory, and anti-tumor properties. Notably, shown remarkable potential in cancer therapy by targeting multiple mechanisms; it induces apoptosis, inhibits proliferation, blocks angiogenesis, reduces the metastatic of cells. Furthermore, enhances sensitivity cells chemotherapy modulating key signaling pathways. Beyond neoplastic diseases, also presents promising therapeutic applications managing non-cancerous conditions such as diabetes, Alzheimer’s disease, pulmonary fibrosis. This review comprehensively examines molecular mechanisms underlying hyperoside’s anti-cancer effects highlights role treatment cancers, including lung colorectal cancers. Additionally, explores latest research on addressing non-neoplastic conditions, fibrosis, Parkinson’s disease. By summarizing current findings, this underscores unique value a multifunctional both contexts.

Язык: Английский

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Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

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Study on the Modulation of NLRP1 by Natural Products in Neurodegenerative Diseases

Natural Product Communications, Год журнала: 2025, Номер 20(3)

Опубликована: Март 1, 2025

Neuronal pyroptosis is one of the crucial pathogenesis neurodegenerative diseases, and signaling pathway mediated by inflammasome main pyroptosis. Neuroinflammation not only a common feature, but also an essential basis for diagnosis diseases. important pathological feature nervous system diseases such as Alzheimer's disease (AD), Parkinson's (PD). NLRP1 plays role in activating inducing inflammatory response, so development drugs targeting regulation has become reasonable research direction treatment By analyzing current progress which affects process neuronal related Chinese medicine, natural products were docked with targets to find higher activity. The target CB-Dock molecular docking platform. Molecular results showed that silibinin, crocin, hyperoside had excellent binding affinity, most promising potential active compounds AD regulating NLRP1. This paper discusses feasibility rationality medicine on future.

Язык: Английский

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From fruit to functional food: Eriobotrya japonica’s potential in managing obesity and Alzheimer's disease

South African Journal of Botany, Год журнала: 2025, Номер 180, С. 531 - 540

Опубликована: Март 31, 2025

Язык: Английский

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Role of Achyranthes aspera in neurodegenerative diseases: current evidence and future directions

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 9, 2025

Neurodegenerative diseases are caused by the progressive degeneration of neurons and/or their myelin sheaths, ultimately leading to cognitive and motor dysfunction. Due complex pathogenesis limited efficacy therapeutic drugs, these have attracted significant attention. Achyranthes aspera, belongs family Amaranthaceae, has been extensively used in traditional folk medicines for treatment various ailments. Modern research revealed that aspera possesses pharmacological effects, including cardiocerebrovascular protection, immune regulation, antioxidation, anti-aging. Furthermore, neuroprotective effects confirmed numerous scientific studies. This review focuses on primary mechanisms prevention neurodegenerative diseases, as well potential application prospects. aims provide insights into clinical applications directions diseases.

Язык: Английский

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Hyperoside alleviates zearalenone-induced liver injury by regulating mitochondrial calcium overload mediated excessive autophagy

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156880 - 156880

Опубликована: Май 1, 2025

Язык: Английский

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