Thirty years of NRF2: advances and therapeutic challenges

Nature Reviews Drug Discovery, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

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Wearables in Chronomedicine and Interpretation of Circadian Health

Diagnostics, Год журнала: 2025, Номер 15(3), С. 327 - 327

Опубликована: Янв. 30, 2025

Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.

Язык: Английский

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Structure characterization of polysaccharides from Cistanche deserticola and their neuroprotective effects against oxidative stress in slow transit constipation mice

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129527 - 129527

Опубликована: Янв. 19, 2024

Язык: Английский

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Detection of NADH and NADPH levels in vivo identifies shift of glucose metabolism in cancer to energy production

FEBS Journal, Год журнала: 2024, Номер 291(12), С. 2674 - 2682

Опубликована: Фев. 5, 2024

Profound changes in the metabolism of cancer cells have been known for almost 100 years, and many aspects these continued to be actively studied discussed. Differences results various studies can explained by diversity tumours, which differing processes energy metabolism, limitations methods used. Here, using fluorescence lifetime needle optical biopsy a hepatocellular carcinoma (HCC) mouse model patients with HCC, we measured reduced nicotinamide adenine dinucleotide (NADH) phosphate (NADPH) control liver, HCC tumours their adjacent regions. We found that NADH level (mostly responsible metabolism) is increased but also regions same liver. NADPH significantly decreased model. However, ex vivo tumour slices reactive oxygen species production glutathione (both dependent on NADPH) were suppressed. Thus, glucose-dependent changed more pronounced shift (NADH), rather than synthesis redox balance.

Язык: Английский

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Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome

Antioxidants and Redox Signaling, Год журнала: 2024, Номер 41(10-12), С. 744 - 768

Опубликована: Янв. 6, 2024

Significance: Metabolic syndrome (MetS) has become a major global public health problem and there is an urgent need to elucidate its pathogenesis find more effective targets modalities for intervention.

Язык: Английский

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Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation

EMBO Molecular Medicine, Год журнала: 2025, Номер 17(2), С. 301 - 335

Опубликована: Янв. 6, 2025

Abstract Current studies pictured the enteric nervous system and macrophages as modulators of neuroimmune processes in inflamed gut. Expanding this view, we investigated impact neuron–macrophage interactions on postoperative trauma subsequent motility disturbances, i.e., ileus. In early postsurgical phase, detected strong neuronal activation, followed by transcriptional translational signatures indicating death synaptic damage. Simultaneously, our study revealed neurodegenerative profiles macrophage-specific transcriptomes after trauma. Validating role resident monocyte-derived macrophages, depleted CSF-1R-antibodies used CCR2 −/− mice, known for reduced monocyte infiltration, POI studies. Only CSF-1R-antibody-treated animals showed decreased lessened decay, emphasizing significance macrophages. human gut samples taken late during abdominal surgery, substantiated mouse model data found reactive apoptotic neurons dysregulation genes, a species’ overarching mechanism. Our demonstrates that surgical activates induces neurodegeneration, mediated introducing neuroprotection an option faster recovery surgery.

Язык: Английский

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RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection

FEBS Journal, Год журнала: 2024, Номер 291(9), С. 1944 - 1957

Опубликована: Фев. 9, 2024

The transmembrane receptor for advanced glycation end products (RAGE) is a signaling many damage‐ and pathogen‐associated molecules. Activation of RAGE associated with inflammation an increase in reactive oxygen species (ROS) production. Although several sources ROS have been previously suggested, how induces production still unclear, considering the multiple targets Here, using acute brain slices primary co‐culture cortical neurons astrocytes, we investigated effects range synthetic peptides corresponding to fragments V‐domain on redox signaling. We found that fragment (60–76) activation astrocytes from slices. This effect occurred through could be blocked by inhibitor. stimulates NADPH oxidase (NOX). RAGE‐induced NOX produced only minor decreases glutathione levels increased rate lipid peroxidation, although it also reduced basal β‐amyloid induced cell death astrocytes. Thus, specific NOX, which can part protective mechanism.

Язык: Английский

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Nrf2 as a regulator of energy metabolism and mitochondrial function

FEBS Letters, Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Nuclear factor erythroid‐2‐related 2 (Nrf2) is essential for the control of cellular redox homeostasis. When activated, Nrf2 elicits cytoprotective effects through expression several genes encoding antioxidant and detoxifying enzymes. can also improve defense via pentose phosphate pathway by increasing NADPH availability to regenerate glutathione. Microarray genome‐wide localization analyses have identified many target beyond those linked its redox‐regulatory capacity. regulates intermediary metabolic pathways involved in cancer cell reprogramming, contributing malignant phenotypes. modulates substrate utilization mitochondrial respiration. Here we review experimental evidence supporting role regulation energy metabolism function.

Язык: Английский

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Energy substrate supplementation increases ATP levels and is protective to PD neurons

Current Research in Pharmacology and Drug Discovery, Год журнала: 2024, Номер 6, С. 100187 - 100187

Опубликована: Янв. 1, 2024

Alteration of mitochondrial metabolism by various mutations or toxins leads to neurological conditions. Age-related changes in energy could also play the role a trigger for neurodegenerative disorders. Nonetheless, it is not clear if restoration ATP production supplementation brain cells with substrates be neuroprotective. Using primary neurons and astrocytes, familial forms disorders we studied whether improve stimulate production, increased levels protect against glutamate excitotoxicity neurodegeneration. We found that several substrates, combination thereof, TCA cycle cellular respiration, oxidative phosphorylation resulted an increase NADH level membrane potential led astrocytes. Subsequently, these were protected deprivation during ischemia excitotoxicity. Provision Parkinson's disease prevented triggering cell death. Thus, can neuroprotective A succinate salt choline nicotinamide provided best results.

Язык: Английский

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Antioxidant network-based signatures cluster glioblastoma into distinct redox-resistant phenotypes

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 18, 2024

Aberrant reactive oxygen species (ROS) production is one of the hallmarks cancer. During their growth and dissemination, cancer cells control redox signaling to support protumorigenic pathways. As a consequence, become reliant on major antioxidant systems maintain balanced tone, while avoiding excessive oxidative stress cell death. This concept appears especially relevant in context glioblastoma multiforme (GBM), most aggressive form brain tumor characterized by significant heterogeneity, which contributes treatment resistance recurrence. From this viewpoint, study aims investigate whether gene regulatory networks can effectively capture diverse states associated with primary phenotypes GBM.

Язык: Английский

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