Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 10, 2025
The
literature
on
the
role
of
pleomorphic
adenoma
gene
1
(PLAG1)
in
malignant
tumors
is
limited.
This
study
aimed
to
perform
pan-cancer
analysis
PLAG1.
expression
PLAG1
was
analyzed
by
Human
Protein
Atlas
(HPA).
differential
and
prognosis
were
based
TCGA
data.
relationship
between
tumor
heterogeneity,
stemness
immune
infiltration
investigated.
enrichment
biological
function
bladder
cancer
analyzed.
increased
a
variety
significantly
correlated
with
patients.
Their
levels
associated
key
checkpoint
genes
(CD274,
HAVCR2),
stimulation
factors
(CD48,
CD27).
In
cancer,
functional
indicated
that
involved
epidermal
related
processes
pathways.
reduction
can
inhibit
proliferation
cells.
has
potential
be
prognostic
marker
therapeutic
target
for
patients
tumors.
Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
14(7), С. 100960 - 100960
Опубликована: Март 8, 2024
Ferroptosis
is
a
nonapoptotic
form
of
cell
death
and
differs
considerably
from
the
well-known
forms
in
terms
morphology,
genetics,
biochemistry.
The
three
primary
pathways
for
ferroptosis
are
system
Xc-/glutathione
peroxidase
4
(GPX4),
lipid
metabolism,
ferric
metabolism.
Since
discovery
ferroptosis,
mounting
evidence
has
revealed
its
critical
regulatory
role
several
diseases,
especially
as
novel
potential
target
cancer
therapy,
thereby
attracting
increasing
attention
fields
tumor
biology
anti-tumor
therapy.
Accordingly,
broad
prospects
exist
identifying
therapeutic
target.
In
this
review,
we
aimed
to
systematically
summarize
activation
defense
mechanisms
highlight
targets,
discuss
design
nanomedicines
regulation.
addition,
opted
present
advantages
disadvantages
current
research
provide
an
optimistic
vision
future
directions
related
fields.
Overall,
aim
new
ideas
further
inspire
strategies
disease
diagnosis
treatment.
Cancer Drug Resistance,
Год журнала:
2025,
Номер
8(1)
Опубликована: Янв. 6, 2025
Ferroptosis
is
an
iron-dependent
form
of
programmed
cell
death
induced
by
lipid
peroxidation.
This
process
regulated
signaling
pathways
associated
with
redox
balance,
iron
metabolism,
and
metabolism.
Cancer
cells'
increased
demand
makes
them
especially
susceptible
to
ferroptosis,
significantly
influencing
cancer
development,
therapeutic
response,
metastasis.
Recent
findings
indicate
that
cells
can
evade
ferroptosis
downregulating
key
related
this
process,
contributing
drug
resistance.
underscores
the
possibility
modulating
as
approach
counteract
resistance
enhance
efficacy.
review
outlines
involved
in
their
interactions
cancer-related
pathways.
We
also
highlight
current
understanding
resistance,
offering
insights
into
how
targeting
provide
novel
approaches
for
drug-resistant
cancers.
Finally,
we
explore
potential
ferroptosis-inducing
compounds
examine
challenges
opportunities
development
evolving
field.
RSC Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Tubastatin
A
derivatives
based
on
bi-,
tri-,
and
tetracyclic
cap
groups
were
synthesized.
Derivative
14f
exhibits
the
best
antiproliferative
activity
against
SUNE1,
MDA-MB-231
cancer
cells,
with
IC
50
values
of
0.51
0.52
μM,
respectively.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
This
chapter
explores
how
to
regulate
programmed
cell
death
and
its
relevance
in
cancer
therapy.
It
points
the
need
of
investigate
mechanisms
death,
like
apoptosis,
necroptosis,
and,
more
recently,
exposed
ferroptosis,
while
creating
approaches
for
treatment
malignant
diseases.
In
spite
progress
field
targeted
therapies,
is
still
a
main
cause
due
incapability
cells
undergo
apoptosis.
The
highlights
significance
adopting
complex
that
encompass
multiple
types
occurring
within
both
tumor
microenvironment.
Of
note
are
functions
oncogenes
suppressor
genes
regulation
cellular
processes,
specific
role
apoptosis
formation
process,
possibility
increase
neoplastic
cells.
There
metastasis
critical
such
as
TP53
gene,
along
with
presence
an
over
expression
anti-apoptotic
proteins.
Examples
this
would
include
Bcl-2
IAPs,
which
protect
against
stimuli
required
death.
immunotherapy
combination
therapies
described
emerging
strategies
enhance
efficacy
treatments.
document
also
deals
problem
resistance
induction
necessity
further
clinical
studies
new
therapeutic
agents
practice.
summary,
it
diversity
biology
paradigm
shift
achieve
Interactive Journal of Medical Research,
Год журнала:
2025,
Номер
14, С. e66286 - e66286
Опубликована: Фев. 26, 2025
Background
Ferroptosis,
as
a
novel
modality
of
cell
death,
holds
significant
potential
in
elucidating
the
pathogenesis
and
advancing
therapeutic
strategies
for
breast
cancer.
Objective
This
study
aims
to
comprehensively
analyze
current
ferroptosis
research
future
trends,
guiding
cancer
advancements
innovative
treatment
strategies.
Methods
used
R
package
Bibliometrix
(Department
Economic
Statistical
Sciences
at
University
Naples
Federico
II),
VOSviewer
(Centre
Science
Technology
Studies
Leiden
University),
CiteSpace
(Drexel
University’s
College
Information
Technology),
conduct
bibliometric
analysis
387
papers
on
from
Web
Core
Collection.
The
covers
authors,
institutions,
journals,
countries
or
regions,
publication
volumes,
citations,
keywords.
Results
number
publications
related
this
field
has
surged
annually,
with
China
United
States
collaborating
closely
leading
output.
Sun
Yat-sen
stands
out
among
while
journal
Frontiers
Oncology
author
Efferth
T
contribute
significantly
field.
Highly
cited
within
domain
primarily
focus
induction
ferroptosis,
protein
regulation,
comparisons
other
modes
providing
foundation
treatment.
Keyword
highlights
maturity
glutathione
peroxidase
4-related
research,
subtypes
emerging
motor
themes
tumor
microenvironment,
immunotherapy,
prognostic
models
identified
basic
themes.
Furthermore,
application
nanoparticles
serves
an
additional
complement
Conclusions
status
focuses
exploration
relevant
theoretical
mechanisms,
whereas
trends
mechanisms
emphasize
investigation
strategies,
particularly
clinical
immunotherapy
microenvironment.
Nanotherapy
demonstrated
domain.
Future
directions
should
deepen
accelerate
translation
findings
provide
new
insights
innovation
development
