Evaluation of Pericoronary Fat Attenuation Index to Better Identify Culprit Lesions in Acute Coronary Syndrome According to Stenosis Severity DOI
Lili Li,

Jia Tang,

Pinyan Fang

и другие.

Journal of Computer Assisted Tomography, Год журнала: 2024, Номер unknown

Опубликована: Сен. 11, 2024

Objective To investigate the incremental value of pericoronary fat attenuation index (FAI) in routine coronary artery computed tomography angiography (CCTA) to identify culprit lesions acute syndrome (ACS). Methods We reviewed CCTA data from 80 ACS patients and 40 individuals with stable atherosclerosis. patient plaques were categorized into nonculprit groups. The plaque-specific FAI was assessed using Perivascular Fat Analysis Tool. applied a default prespecified window −190 −30 Hounsfield units (HU) broader 20 HU. values within these windows types severity plaque stenosis compared across 3 Additionally, we investigated high-risk characteristics group their correlation FAI. effectiveness worthiness identifying analyzed based on receiver operating characteristic curve. Results under 2 higher than control groups (all P < 0.001). showed most mixed severe In group, significantly lower around calcified (−85.00 ± 9.97 HU) noncalcified (−78.00 11.52 9.24 (both had more plaques, those without (−70.00 7.67 HU vs −82.00 10.16 HU, efficacy that (area curve = 0.799 0.761, 0.042), diagnostic cutoff −77 versus −58 exhibited an for lesions, as 0.970 0.939, Conclusion have controls. is worthy parameter according severity, better option.

Язык: Английский

Angiotensin Regulation of Vascular Homeostasis: Exploring the Role of ROS and RAS Blockers DOI Open Access

Νικόλαος Κούμαλλος,

Evangelia Sigala,

Theodoros Milas

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12111 - 12111

Опубликована: Июль 28, 2023

Extensive research has been conducted to elucidate and substantiate the crucial role of Renin-Angiotensin System (RAS) in pathogenesis hypertension, cardiovascular disorders, renal diseases. Furthermore, oxidative stress maintaining vascular balance well established. It observed that many cellular effects induced by Angiotensin II (Ang II) are facilitated reactive oxygen species (ROS) produced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In this paper, we present a comprehensive overview ROS physiology human blood vessels, specifically focusing on its interaction with RAS. Moreover, delve into mechanisms which clinical interventions targeting RAS influence redox signaling wall.

Язык: Английский

Процитировано

18
Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue DOI Creative Commons
Roberta Cazzola, M. Porta, Gabriele Piuri

и другие.

Antioxidants, Год журнала: 2024, Номер 13(8), С. 893 - 893

Опубликована: Июль 24, 2024

Magnesium (Mg) is involved in essential cellular and physiological processes. Globally, inadequate consumption of Mg widespread among populations, especially those who consume processed foods, its homeostasis impaired obese individuals type 2 diabetes patients. Since deficiency triggers oxidative stress chronic inflammation, common features several frequent non-communicable diseases, interest this mineral growing clinical medicine as well biomedicine. To date, very little known about the role adipose tissue. In obesity, increase fat tissue leads to changes release cytokines, causing low-grade inflammation macrophage infiltration. Hypomagnesemia obesity can potentiate excessive production reactive oxygen species, mitochondrial dysfunction, decreased ATP production. Importantly, plays a regulating intracellular calcium concentration carbohydrate metabolism insulin receptor activity. This narrative review aims consolidate existing knowledge, identify research gaps, raise awareness critical supporting preventing stress.

Язык: Английский

Процитировано

8
SIRT-associated attenuation of cellular senescence in vascular wall DOI
Iliyana Sazdova, Nikola Hadzi‐Petrushev, Milena Keremidarska‐Markova

и другие.

Mechanisms of Ageing and Development, Год журнала: 2024, Номер 220, С. 111943 - 111943

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

7
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning DOI Creative Commons
Xiaojie Liu, Xi Jiang, Jing Hu

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Май 9, 2024

Perivascular adipose tissue (PVAT) dysfunction impairs vascular homeostasis. Impaired inflammation and bone morphogenetic protein-4 (BMP4) signaling are involved in thoracic PVAT by regulating adipokine secretion adipocyte phenotype transformation. We investigated whether aerobic exercise training could ameliorate high-fat diet (HFD)-induced via improved inflammatory response BMP4-mediated pathways.

Язык: Английский

Процитировано

5
Reactive Oxygen Species Are Central Mediators of Vascular Dysfunction and Hypertension Induced by Ethanol Consumption DOI Creative Commons
Júlio C. Padovan, Thales M. H. Dourado, Gustavo Félix Pimenta

и другие.

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1813 - 1813

Опубликована: Сен. 29, 2023

Consumption of high amounts ethanol is a risk factor for development cardiovascular diseases such as arterial hypertension. The hypertensive state induced by complex multi-factorial event, and oxidative stress pathophysiological hallmark vascular dysfunction associated with consumption. Increasing levels reactive oxygen species (ROS) in the vasculature trigger important processes underlying injury, including accumulation intracellular Ca2+ ions, reduced bioavailability nitric oxide (NO), activation mitogen-activated protein kinases (MAPKs), endothelial dysfunction, loss anticontractile effect perivascular adipose tissue (PVAT). enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays central role ROS generation response to ethanol. Activation renin–angiotensin–aldosterone system (RAAS) an upstream mechanism which contributes NADPH stimulation, overproduction ROS, dysfunction. This review discusses mechanisms ethanol, detailing contribution these processes. Data examining association between neuroendocrine changes are also reviewed discussed. These issues paramount interest public health blood pressure elevation general population, it linked conditions diseases.

Язык: Английский

Процитировано

10
The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus DOI Creative Commons
Alessia Valentini, Carmine Cardillo, David Della‐Morte

и другие.

Biomedicines, Год журнала: 2023, Номер 11(11), С. 3006 - 3006

Опубликована: Ноя. 9, 2023

Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable (NCDs) representing leading cause death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in pathogenesis these diseases. Although it is well known systemic inflammation oxidative stress primarily involved development ED, recent have shown perivascular adipose tissue (PVAT) implicated its pathogenesis, also contributing to progression atherosclerosis insulin resistance (IR). In this review, we describe relationship between PVAT analyse CVDs T2DM, further assessing potential therapeutic target with aim restoring normal ED reducing global cardiovascular risk.

Язык: Английский

Процитировано

9
Initial experience with radiomics of carotid perivascular adipose tissue in identifying symptomatic plaque DOI Creative Commons

Ji-Yan Nie,

Wen-Xi Chen, Zhigang Zhu

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Фев. 16, 2024

Carotid atherosclerotic ischemic stroke threatens human health and life. The aim of this study is to establish a radiomics model perivascular adipose tissue (PVAT) around carotid plaque for evaluation the association between Peri-carotid Adipose Tissue structural changes with transient attack.

Язык: Английский

Процитировано

3
Endothelin-1 downregulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity DOI Creative Commons

Anna Lima,

Daniel Rodrigues,

Mirele R. Machado

и другие.

Clinical Science, Год журнала: 2024, Номер 138(17), С. 1071 - 1087

Опубликована: Авг. 30, 2024

Abstract Perivascular adipose tissue (PVAT) negatively regulates vascular muscle contraction. However, in the context of obesity, PVAT releases vasoconstrictor substances that detrimentally affect function. A pivotal player this scenario is peptide endothelin-1 (ET-1), which induces oxidative stress and disrupts The present study postulates obesity augments ET-1 production PVAT, decreases function nuclear factor erythroid 2-related factor-2 (Nrf2) transcription factor, further increasing reactive oxygen species (ROS) generation, culminating dysfunction. Male C57BL/6 mice were fed either a standard or high-fat diet for 16 weeks. Mice also treated with saline daily dose 100 mg·kg−1 ETA ETB receptor antagonist Bosentan, 7 days. Vascular was evaluated thoracic aortic rings, without PVAT. Mechanistic studies utilized from all groups cultured WT-1 mouse brown adipocytes. obese exhibited increased production, ECE1 gene expression, loss anticontractile effect, as well ROS decreased Nrf2 activity, downregulated expression Nrf2-targeted antioxidant genes. Tyr216-phosphorylated-GSK3β KEAP1, but not BACH1 - negative regulators. Bosentan treatment reversed these effects. Similarly, generation activity adipocytes, events mitigated by BQ123 (ETA antagonist). These findings place major contributor to dysfunction highlight pharmacological control effects restores PVAT's cardiovascular protective role.

Язык: Английский

Процитировано

3
Proanthocyanidins-Rich Euterpe Oleracea Mart Seed Extract Prevents Perivascular Adipose Tissue and Vascular Wall Remodeling by Regulating the Renin-Angiotensin System, Inflammation, and Oxidative Damage in Diet-Induced Obese Mice DOI
Matheus Henrique Romão, Graziele Freitas de,

Amanda Faria de Medeiros

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Perivascular adipose tissue and its role in the development of cardiovascular diseases DOI Creative Commons
Л. Д. Хидирова,

V. V. Kovalenko,

A. V. Kuzakova

и другие.

Systemic Hypertension, Год журнала: 2025, Номер 22(1), С. 13 - 17

Опубликована: Март 27, 2025

Perivascular adipose tissue (RVT) is an important component of the vascular system, which actively involved in pathogenesis cardiovascular diseases (CVD). This review based on analysis clinical studies from PubMed, Embase, Web Science, and e-Library databases aimed at studying mechanisms through RVT affects development CVD. It has been proven that prostate a source various pro-inflammatory cytokines, such as TNF-α, IL-6 MCP-1. These molecules contribute to activation inflammatory processes, can lead endothelial damage atherosclerosis. An increase volume pancreas associated with level markers blood, indicates systemic inflammation. metabolism lipids glucose, its excessive accumulation insulin resistance. condition increased risk developing type 2 diabetes Adipokines leptin adiponectin play key role regulating metabolism. Low levels secreted by are tone their response vasodilators vasoconstrictors. Changes function impaired regulation blood pressure atherosclerosis; promote remodeling, also often other factors obesity, dyslipidemia, metabolic syndrome. interact each other, creating complex network contributes Genetic predispositions epigenetic changes affect functions. Some indicate link between genetic RVT, may explain individual differences Thus, plays inflammation, dysfunction, function. Understanding these help new approaches prevention treatment CVD, well identifying potential targets for therapeutic intervention. Further research needed better understand health.

Язык: Английский

Процитировано

0