Dysfunction of perivascular adipose tissue in metabolic syndrome and obesity: the role of the gasotransmitter hydrogen sulfide (review) DOI Open Access
J. G. Birulina, О. В. Воронкова, В. В. Иванов

et al.

Siberian Journal of Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 39(4), P. 18 - 25

Published: Dec. 5, 2024

The development of novel strategies for diagnosing, treating, and preventing cardiovascular diseases (CVDs) linked to metabolic syndrome obesity presents a significant challenge the scientific community. There is pressing need identify effective compounds that target underlying pathogenic mechanisms these disorders. Increasing knowledge about pathogenesis CVDs has highlighted crucial role perivascular adipose tissue (PVAT) in maintaining homeostasis. PVAT metabolically active endocrine organ plays key regulating blood vessel tone, endothelial function, growth proliferation vascular smooth muscle cells. However, disorders, there disruption functional activity cellular components an imbalance production vasoactive substances, leading progression CVDs. This review systematically examines morphofunctional changes associated with obesity, emphasizes dysfunction as pathogenetic factor disease, evaluates potential hydrogen sulfide (H2S) produced by promising vasoregulatory agent based on existing data.

Language: Английский

Angiotensin Regulation of Vascular Homeostasis: Exploring the Role of ROS and RAS Blockers DOI Open Access

Νικόλαος Κούμαλλος,

Evangelia Sigala,

Theodoros Milas

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12111 - 12111

Published: July 28, 2023

Extensive research has been conducted to elucidate and substantiate the crucial role of Renin-Angiotensin System (RAS) in pathogenesis hypertension, cardiovascular disorders, renal diseases. Furthermore, oxidative stress maintaining vascular balance well established. It observed that many cellular effects induced by Angiotensin II (Ang II) are facilitated reactive oxygen species (ROS) produced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In this paper, we present a comprehensive overview ROS physiology human blood vessels, specifically focusing on its interaction with RAS. Moreover, delve into mechanisms which clinical interventions targeting RAS influence redox signaling wall.

Language: Английский

Citations

18
SIRT-associated attenuation of cellular senescence in vascular wall DOI
Iliyana Sazdova, Nikola Hadzi‐Petrushev, Milena Keremidarska‐Markova

et al.

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111943 - 111943

Published: May 17, 2024

Language: Английский

Citations

7
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning DOI Creative Commons
Xiaojie Liu, Xi Jiang, Jing Hu

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 9, 2024

Perivascular adipose tissue (PVAT) dysfunction impairs vascular homeostasis. Impaired inflammation and bone morphogenetic protein-4 (BMP4) signaling are involved in thoracic PVAT by regulating adipokine secretion adipocyte phenotype transformation. We investigated whether aerobic exercise training could ameliorate high-fat diet (HFD)-induced via improved inflammatory response BMP4-mediated pathways.

Language: Английский

Citations

5
Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue DOI Creative Commons
Roberta Cazzola, M. Porta, Gabriele Piuri

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 893 - 893

Published: July 24, 2024

Magnesium (Mg) is involved in essential cellular and physiological processes. Globally, inadequate consumption of Mg widespread among populations, especially those who consume processed foods, its homeostasis impaired obese individuals type 2 diabetes patients. Since deficiency triggers oxidative stress chronic inflammation, common features several frequent non-communicable diseases, interest this mineral growing clinical medicine as well biomedicine. To date, very little known about the role adipose tissue. In obesity, increase fat tissue leads to changes release cytokines, causing low-grade inflammation macrophage infiltration. Hypomagnesemia obesity can potentiate excessive production reactive oxygen species, mitochondrial dysfunction, decreased ATP production. Importantly, plays a regulating intracellular calcium concentration carbohydrate metabolism insulin receptor activity. This narrative review aims consolidate existing knowledge, identify research gaps, raise awareness critical supporting preventing stress.

Language: Английский

Citations

4
Proanthocyanidins-Rich Euterpe Oleracea Mart Seed Extract Prevents Perivascular Adipose Tissue and Vascular Wall Remodeling by Regulating the Renin-Angiotensin System, Inflammation, and Oxidative Damage in Diet-Induced Obese Mice DOI
Matheus Henrique Romão, Graziele Freitas de,

Amanda Faria de Medeiros

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Perivascular adipose tissue and its role in the development of cardiovascular diseases DOI Creative Commons
Л. Д. Хидирова,

V. V. Kovalenko,

A. V. Kuzakova

et al.

Systemic Hypertension, Journal Year: 2025, Volume and Issue: 22(1), P. 13 - 17

Published: March 27, 2025

Perivascular adipose tissue (RVT) is an important component of the vascular system, which actively involved in pathogenesis cardiovascular diseases (CVD). This review based on analysis clinical studies from PubMed, Embase, Web Science, and e-Library databases aimed at studying mechanisms through RVT affects development CVD. It has been proven that prostate a source various pro-inflammatory cytokines, such as TNF-α, IL-6 MCP-1. These molecules contribute to activation inflammatory processes, can lead endothelial damage atherosclerosis. An increase volume pancreas associated with level markers blood, indicates systemic inflammation. metabolism lipids glucose, its excessive accumulation insulin resistance. condition increased risk developing type 2 diabetes Adipokines leptin adiponectin play key role regulating metabolism. Low levels secreted by are tone their response vasodilators vasoconstrictors. Changes function impaired regulation blood pressure atherosclerosis; promote remodeling, also often other factors obesity, dyslipidemia, metabolic syndrome. interact each other, creating complex network contributes Genetic predispositions epigenetic changes affect functions. Some indicate link between genetic RVT, may explain individual differences Thus, plays inflammation, dysfunction, function. Understanding these help new approaches prevention treatment CVD, well identifying potential targets for therapeutic intervention. Further research needed better understand health.

Language: Английский

Citations

0
Correlation Between Fat Attenuation Index and Plaque Parameters in Coronary CT Angiography: An Observational Study in Stable Coronary Artery Disease DOI Creative Commons
Ting Guo, Xiuping Wang, Rui Xia

et al.

Clinical and Applied Thrombosis/Hemostasis, Journal Year: 2025, Volume and Issue: 31

Published: April 1, 2025

Background The purpose of this prospective observational study was to predict plaque vulnerability, stenosis, and hemodynamic problems based on coronary CT angiography (CCTA) using the Fat Attenuation Index (FAI) as a marker. Methods Patients with stable artery disease (CAD) who underwent CCTA between January 2021 2023 were included in study. Data basic patient information, parameters, Fractional Flow Reserve (FFR) collected analyzed. Multiple linear analysis performed explore association FAI FFR. Additionally, regression models developed dependent variables such FFR, degree stenosis values. We also explored specific thresholds classify plaques into vulnerable non-vulnerable categories. Results A total 62 patients 84 arteries final analysis. Based levels, subjects divided FAI-negative group (FAI ≤ −70.1 HU, 52 cases) FAI-positive > 32 cases). had significantly lower FFR values compared those group, proportion higher group. Furthermore, observed increased, showed significant increase. Analysis types revealed that than other types. In multiple analysis, lesion length, TPB negatively correlated (β = −0.25, −0.13 −41.72). Conclusion results support use valuable tool clinical practice. Its predictive capabilities regarding dysfunction susceptibility make it an essential component modern cardiovascular risk assessment strategies.

Language: Английский

Citations

0
Reactive Oxygen Species Are Central Mediators of Vascular Dysfunction and Hypertension Induced by Ethanol Consumption DOI Creative Commons
Júlio C. Padovan, Thales M. H. Dourado, Gustavo Félix Pimenta

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1813 - 1813

Published: Sept. 29, 2023

Consumption of high amounts ethanol is a risk factor for development cardiovascular diseases such as arterial hypertension. The hypertensive state induced by complex multi-factorial event, and oxidative stress pathophysiological hallmark vascular dysfunction associated with consumption. Increasing levels reactive oxygen species (ROS) in the vasculature trigger important processes underlying injury, including accumulation intracellular Ca2+ ions, reduced bioavailability nitric oxide (NO), activation mitogen-activated protein kinases (MAPKs), endothelial dysfunction, loss anticontractile effect perivascular adipose tissue (PVAT). enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays central role ROS generation response to ethanol. Activation renin–angiotensin–aldosterone system (RAAS) an upstream mechanism which contributes NADPH stimulation, overproduction ROS, dysfunction. This review discusses mechanisms ethanol, detailing contribution these processes. Data examining association between neuroendocrine changes are also reviewed discussed. These issues paramount interest public health blood pressure elevation general population, it linked conditions diseases.

Language: Английский

Citations

9
The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus DOI Creative Commons
Alessia Valentini, Carmine Cardillo, David Della‐Morte

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3006 - 3006

Published: Nov. 9, 2023

Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable (NCDs) representing leading cause death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in pathogenesis these diseases. Although it is well known systemic inflammation oxidative stress primarily involved development ED, recent have shown perivascular adipose tissue (PVAT) implicated its pathogenesis, also contributing to progression atherosclerosis insulin resistance (IR). In this review, we describe relationship between PVAT analyse CVDs T2DM, further assessing potential therapeutic target with aim restoring normal ED reducing global cardiovascular risk.

Language: Английский

Citations

9
Initial experience with radiomics of carotid perivascular adipose tissue in identifying symptomatic plaque DOI Creative Commons

Ji-Yan Nie,

Wen-Xi Chen, Zhigang Zhu

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 16, 2024

Carotid atherosclerotic ischemic stroke threatens human health and life. The aim of this study is to establish a radiomics model perivascular adipose tissue (PVAT) around carotid plaque for evaluation the association between Peri-carotid Adipose Tissue structural changes with transient attack.

Language: Английский

Citations

3