Current insights into human pathogenic phenuiviruses and the host immune system
Virulence,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 29, 2024
Phenuiviruses
are
a
class
of
segmented
negative-sense
single-stranded
RNA
viruses,
typically
consisting
three
segments
that
encode
four
distinct
proteins.
The
emergence
pathogenic
phenuivirus
strains,
such
as
Rift
Valley
fever
phlebovirus
(RVFV)
in
sub-Saharan
Africa,
Severe
Fever
with
Thrombocytopenia
Syndrome
Virus
(SFTSV)
East
and
Southeast
Asia,
Heartland
(HRTV)
the
United
States
has
presented
considerable
challenges
to
global
public
health
recent
years.
innate
immune
system
plays
crucial
role
initial
defense
mechanism
host
against
invading
pathogens.
In
addition
continued
research
aimed
at
elucidating
epidemiological
characteristics
phenuivirus,
significant
advancements
have
been
made
investigating
its
viral
virulence
factors
(glycoprotein,
non-structural
protein,
nucleoprotein)
potential
host–pathogen
interactions.
Specifically,
efforts
focused
on
understanding
mechanisms
evasion,
assembly
egress,
networks
involving
cells,
programmed
cell
death,
inflammation,
nucleic
acid
receptors,
etc.
Furthermore,
plethora
technological
advancements,
including
metagenomics,
metabolomics,
single-cell
transcriptomics,
proteomics,
gene
editing,
monoclonal
antibodies,
vaccines,
utilized
further
our
pathogenesis
responses.
Hence,
this
review
aims
provide
comprehensive
overview
current
recognition,
therapeutic
approaches
during
human
infections
focusing
particularly
RVFV
SFTSV.
Язык: Английский
The Impact of Non-Thyroidal Illness Syndromes on The Prognosis and Immune Profile in Severe Fever with Thrombocytopenia Syndrome Patients
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 1439 - 1449
Опубликована: Март 1, 2025
Non-thyroidal
illness
syndrome
(NTIS)
is
the
most
common
endocrine
dysfunction
in
critically
ill
patients
and
often
associated
with
poor
prognosis.
Thyroid
immune
cell
disturbances
are
frequently
observed
severe
fever
thrombocytopenia
(SFTS).
This
study
aims
to
evaluate
impact
of
NTIS
on
prognosis
SFTS
explore
relationship
between
thyroid
hormones
(THs)
profiles.
Adult
admitted
Yantai
Qishan
Hospital
for
from
January
2023
December
no
prior
history
disease
were
retrospectively
recruited.
Multivariable
regressions
used
assess
associations
clinical
outcomes.
Spearman
correlation
analysis
was
conducted
relationships
cells
THs.
categorized
into
four
subtypes
based
different
levels
FT4
TSH,
association
mortality
further
analyzed.
Of
84
included
study,
62
(73.8%)
diagnosed
NTIS.
Independent
risk
predictors
which
may
affect
include
subtype
(P
=0.002),
viral
load
=
0.029),
FT3
0.032),
0.041).
exhibited
a
higher
rate
compared
euthyroid
0.033).
revealed
that
LYM,
LYM%,
MONO,
MONO%,
BAS,
CD3+T,
CD3+T%,
Th,
Th%
positively
correlated
FT3,
FT4,
or
TSH
levels.
more
likely
present
coagulation
abnormalities
(APTT,
P
0.005;
D-Dimer,
<
0.001),
liver
enzyme
(AST,
electrolyte
imbalances
(Sodium,
0.003),
elevated
LDH
increased
ɑ-HBDH
0.003).
patients,
have
lower
survival
patients.
The
type
3
than
those
1.
Язык: Английский
Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Май 23, 2025
Abstract
Background
Higher
embryonic
mortality,
especially
in
aged
breeding
hens,
is
associated
with
insufficient
hepatic
functionality
maintaining
redox
homeostasis.
Our
previous
study
demonstrated
that
egg
exosome-derived
miRNAs
may
play
a
key
role
modulating
oxidation-reduction
process,
whereas
the
exact
function
and
mechanism
were
still
poorly
understood.
The
present
aimed
to
investigate
roles
of
exosome
dynamic
equilibrium
free
radicals
peroxide
agents
liver,
as
well
demonstrate
specific
using
oxidative
stress-challenged
hepatocytes.
Results
Compared
36-week-old
decreased
hatchability
increased
mortality
observed
65-week-old
hens.
Meanwhile,
older
group
showed
MDA
levels
SOD
GSH-Px
activities
muscle
serum.
Embryonic
was
significantly
positively
correlated
level
negatively
activity
liver.
In
addition,
363
differentially
expressed
genes
(DEGs)
identified
13
(DE-miRNAs)
exosomes.
These
DEGs
DE-miRNAs
involved
oxidoreductase
activity,
glutathione
metabolic
MAPK
signaling
pathway,
apoptosis
autophagy.
miRNA-mRNA
network
analysis
further
found
targeted
by
mainly
enriched
programmed
cell
death,
such
Wherein,
MAPK10
highest
MCC
AUC
values
related
level,
served
target
gene
miR-145-5p
based
on
dual
luciferase
reporter
experiment
correlation
analysis.
Bioinformatics
miR-145-5p/
axis
might
alleviate
generation
apoptosis.
primary
hepatocytes
chick
embryos,
transfection
reversed
H
2
O
-induced
mitochondrial
ROS
increase,
,
BAX
CASP3
overexpression
excessive
Conclusion
Exosome
eggs
could
decrease
ROS,
attenuating
damage
embryos.
findings
provide
new
theoretical
basis
for
improvement
maternal
physiological
status
maintain
homeostasis
nutritional
or
genetic
modifications.
Graphical
Язык: Английский
Development and validation of the PLNA score to predict cytokine storm in acute-phase SFTS patients: A single-center cohort study
International Immunopharmacology,
Год журнала:
2024,
Номер
136, С. 112288 - 112288
Опубликована: Май 31, 2024
Severe
fever
with
thrombocytopenia
syndrome
(SFTS)
is
an
emerging
infectious
disease
known
for
its
high
mortality
rate
and
correlation
Cytokine
Storms
(CS).
Timely
detection
of
CS
crucial
improving
the
prognosis
disease.
The
objective
this
investigation
was
to
develop
a
model
identifying
cytokine
storms
in
acute
phase
SFTS.
Язык: Английский
Construction and validation of a dynamic nomogram using Lasso-logistic regression for predicting the severity of severe fever with thrombocytopenia syndrome patients at admission
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 18, 2024
Язык: Английский
RNA transcriptome analysis of platelets revealed altered platelet responses and the mechanism of thrombocytopenia in SFTS
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 6, 2023
Abstract
Background
Severe
fever
with
thrombocytopenia
syndrome
(SFTS)
is
an
emerging
tick-borne
viral
hemorrhagic
disease
caused
by
infection
Dabie
bandavirus
(SFTS
virus,
SFTSV).
Thrombocytopenia
the
primary
clinical
feature
of
SFTS
and
significantly
associated
severity.
However,
pathological
mechanism
in
remains
unclear.
Methods
Platelets
purified
from
patients
were
subjected
to
RNA
transcriptome
analyses.
Differentially
expressed
genes
(DEGs)
platelets
deceased
surviving
identified,
their
functions
transcription
levels
characterized.
DEGs
related
cell
death
compared
COVID-19
dengue
patients.
The
percentage
positive
for
biomarkers
pyroptosis,
apoptosis,
necroptosis,
autophagy,
ferroptosis
was
determined
flow
cytometry.
analyses
also
performed
nonlethal
SFTSV
model
mice.
representing
functional
changes
mouse
characterized,
platelet
investigated.
Functional
SFTSV-infected
mice
determine
different
mechanisms
underlying
humans
Results
Platelet
revealed
altered
functioning
suggested
active
response
but
not
fatal
Enhanced
neutrophil
activation,
interferon
(IFN)
signaling,
virus
life
cycle
common
responses
SFTS.
increased
histone
methylation
impaired
vesicle
organization
may
be
outcome,
while
enhanced
protein
transport
membrane
catabolic
process
contribute
recovery.
Moreover,
resulted
loss
via
autophagy
ferroptosis.
Unlike
patients,
play
a
role
mainly
regulating
adaptive
immunity,
as
severe
that
humans.
Conclusions
This
study
humans,
which
are
those
infected
SFTSV.
results
deepen
our
understanding
pathogenesis
provides
insights
subsequent
studies
on
development
novel
intervention
strategies.
Язык: Английский