bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 4, 2024
Abstract
Chemical
pollution
in
coastal
waters,
particularly
from
agricultural
runoff
organophosphates,
poses
a
significant
threat
to
marine
ecosystems,
including
coral
reefs.
Pollutants
such
as
chlorpyrifos
(CPF)
are
widely
used
agriculture
and
have
adverse
effects
on
life
humans.
In
this
paper,
we
investigate
the
impact
of
CPF
metamorphosis
reef
fish
model,
clownfish
Amphiprion
ocellaris
,
focusing
disruption
thyroid
hormone
(TH)
signalling
pathways.
Our
findings
reveal
that
by
reducing
TH
levels,
exposure
impairs
formation
characteristic
white
bands
larvae,
indicative
progression.
Interestingly,
treatment
can
rescue
these
effects,
establishing
direct
causal
link
between
effect
disruption.
The
body
shape
changes
occurring
during
also
impacted
exposure,
less
advanced
CPF-treated
larvae
than
control
conditions.
Moreover,
transcriptomic
analysis
elucidates
CPF’s
all
components
pathway.
Additionally,
induces
systemic
cholesterol
vitamin
D
metabolism,
DNA
repair,
immunity,
highlighting
its
broader
TH-independent
impacts.
often
overlooked
Developing
enhancing
models,
offers
more
comprehensive
understanding
how
chemical
affects
ecosystems.
This
approach
provides
new
insights
into
complex
mechanisms
underlying
toxicity
metamorphosis,
shedding
light
environmental
pollutants
organisms.
Highlights
Chlorpyrifos
is
an
insecticide
for
past
five
decades
has
humans
progression
During
lose
their
elongated
transform
miniature
ovoid-shaped
adults,
impacts
Neurobiology of Disease,
Год журнала:
2024,
Номер
202, С. 106710 - 106710
Опубликована: Окт. 28, 2024
Neurodegenerative
diseases
(NDs)
are
a
type
of
common
chronic
progressive
disorders
characterized
by
damage
to
specific
cell
populations
in
the
nervous
system,
ultimately
leading
disability
or
death.
Effective
treatments
for
these
still
lacking,
due
limited
understanding
their
pathogeneses,
which
involve
multiple
cellular
and
molecular
pathways.
The
triggering
an
immune
response
is
feature
neurodegenerative
disorders.
A
critical
challenge
intricate
interplay
between
neuroinflammation,
neurodegeneration,
responses,
not
yet
fully
characterized.
In
recent
years,
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
gene
(STING)
pathway,
crucial
intracellular
DNA
sensing,
has
gradually
gained
attention.
However,
roles
this
pathway
within
types
such
as
cells,
glial
neuronal
its
contribution
ND
pathogenesis,
remain
elucidated.
review,
we
systematically
explore
how
cGAS-STING
signaling
links
various
with
related
effector
pathways
under
context
NDs
multifaceted
therapeutic
directions.
We
emphasize
discovery
condition-dependent
heterogeneity
integral
diverse
responses
potential
targets.
Additionally,
review
pathogenic
role
activation
Parkinson's
disease,
ataxia-telangiectasia,
amyotrophic
lateral
sclerosis.
focus
on
complex
bidirectional
Alzheimer's
Huntington's
sclerosis,
revealing
double-edged
nature
disease
progression.
objective
elucidate
pivotal
pathogenesis
catalyze
new
insights
facilitating
development
novel
strategies.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 23, 2024
The
liver,
a
complex
parenchymal
organ,
possesses
distinctive
microcirculatory
system
crucial
for
its
physiological
functions.
An
intricate
interplay
exists
between
hepatic
disturbance
and
the
manifestation
of
pathological
features
in
diverse
liver
diseases.
This
review
updates
main
characteristics
disturbance,
including
sinusoidal
capillarization,
narrowing
space,
portal
hypertension,
angiogenesis,
as
well
their
formation
mechanisms.
It
also
summarized
detection
methods
microcirculation.
Simultaneously,
we
have
reviewed
diseases
such
acute
failure,
ischemia-reperfusion
injury,
viral
hepatitis,
non-alcoholic
fatty
disease,
fibrosis,
cirrhosis,
hepatocellular
carcinoma.
Finally,
this
summarizes
advancement
microcirculation
attributed
to
traditional
Chinese
medicine
(TCM)
active
metabolites,
providing
novel
insights
into
application
TCM
treating
Journal of Toxicologic Pathology,
Год журнала:
2024,
Номер
38(1), С. 17 - 26
Опубликована: Сен. 10, 2024
Acute
kidney
injury
induced
by
stings
from
multiple
wasps
is
a
medical
emergency
and
driving
factor
of
acute
renal
dysfunction.
Numerous
studies
have
shown
that
mitochondrial
reactive
oxygen
species
(mtROS)
play
key
role
in
ischemia-reperfusion
injury-,
cisplatin-,
sepsis-induced
injury.
However,
the
mtROS
its
underlying
mechanisms
wasp-venom-induced
remain
inconclusive.
In
this
study,
we
investigated
damage
inflammation
mouse
model
using
wasp
venom.
Changes
function,
transcription
A
(TFAM)
expression,
DNA
maintenance
levels,
stimulator
interferon
gene
(STING)
inflammatory
mediator
levels
mice
with
or
without
scavenger
Mito-Tempo
were
analyzed
vivo.
Downregulation
reversed
dysfunction,
reduced
STING
expression
kidneys
mice.
The
suppression
also
improved
decrease
TFAM
copy
numbers
summary,
existing
evidence
study
shows
contribute
significantly
to
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(43), С. 24046 - 24057
Опубликована: Окт. 18, 2024
T-2
toxin
induces
cell
immunotoxicity
by
triggering
an
intracellular
hypoxic
microenvironment
and
activates
hypoxia-inducible
factor-1α
(HIF-1α),
which
exerts
cellular
protective
effects.
Mycotoxins
can
also
induce
senescence.
The
aging
of
immune
function,
termed
"immunosenescence,"
is
important
factor
in
the
decline
biological
immunity
accelerates
However,
mechanism
underlying
toxin-induced
immunosenescence
remains
unclear.
This
study
aimed
to
elucidate
roles
HIF-1α
cGAS-STING
signaling
this
process
uncover
mechanisms
through
impacts
cytoskeletal
integrity
senescence
using
a
RAW264.7
macrophage
model.
cells
were
treated
with
(14
nM)
for
1–24
h.
We
revealed
that
activating
HIF-1α/cGAS-STING
axis.
pathway
promotes
apoptosis;
however,
we
negatively
regulated
pathway,
thereby
inhibiting
apoptosis.
PARP
1
cleavage
caspase
3/9
inhibited
DNA
repair
accelerated
transition
from
At
late
stages
exposure
(12
h),
disrupting
dynamic
balance
α-tubulin
F-actin
destabilizing
structure.
Our
research
demonstrates
serving
as
negative
regulator.
provides
deeper
understanding
immunosenescence.
