International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113945 - 113945
Опубликована: Дек. 25, 2024
Язык: Английский
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер 15(3), С. 1480 - 1496
Опубликована: Янв. 2, 2025
Although clinical evidence suggests that nonalcoholic fatty liver disease is an established major risk factor for heart failure, it remains unexplored whether sleep disorder-caused hepatic damage contributes to the development of cardiovascular (CVD). Here, our findings revealed fragmentation (SF) displayed notable detrimental phenotypes, including steatosis and oxidative damage, along with significant abnormalities in cardiac structure function. All these pathological changes persisted even after recovery 2 consecutive weeks or more, displaying memory properties. Mechanistically, persistent higher expression nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) was key initiator SF-accelerated phenotypes. SF epigenetically controlled acetylation histone H3 lysine 27 (H3K27ac) enrichment at Nox4 promoter markedly increased recovery. Moreover, fine coordination circadian clock strictly by BMAL1-dependent Sirtuin 1 (Sirt1) transcription misalignment. Accordingly, genetic manipulation liver-specific Sirt1, pharmacological intervention targeting NOX4 (GLX351322) SIRT1 (Resveratrol), could effectively erase epigenetic modification reducing H3K27ac level ameliorate progression pathology, thereby counteracting SF-evoked sustained CVD. Collectively, may pave way strategies mitigate myocardial injury from diabetic patients.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Янв. 21, 2025
Adropin is a secreted peptide encoded by the energy homeostasis-associated gene (ENHO), located chromosome 9p13.3, with conserved amino acid sequence across humans and mice. Its expression regulated various factors, including fat, LXRα, ERα, ROR, STAT3. plays critical role in glucose lipid metabolism, as well insulin resistance, modulating multiple signaling pathways that contribute to reduction of obesity improvement blood homeostasis. Additionally, it influences immune cells inflammation, exerting anti-inflammatory effects diseases. While extensive research has summarized regulation cellular metabolism adropin, limited studies have explored its inflammation. To enhance understanding adropin’s immune-modulating mechanisms, this review synthesizes recent findings on conditions such atherosclerosis, diabetes, fatty liver, non-alcoholic hepatitis, Furthermore, discusses current limitations outlines potential future directions for adropin-related investigations. It hoped ongoing into adropin will significantly advancement medical treatments
Язык: Английский
Процитировано
1
International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114678 - 114678
Опубликована: Апрель 18, 2025
Язык: Английский
Процитировано
1
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Июль 4, 2024
Non-alcoholic fatty liver disease (NAFLD) is a prevalent and significant global public health issue. Nonalcoholic steatohepatitis (NASH) represents an advanced stage of NAFLD in terms pathology. However, the intricate mechanisms underlying progression from to NASH remain elusive. Ferroptosis, characterized by iron-dependent cell death distinguished other forms based on morphological, biochemical, genetic criteria, has emerged as potential participant with pivotal role driving progression. Nevertheless, its precise mechanism remains poorly elucidated. In this review article, we comprehensively summarize pathogenesis NAFLD/NASH ferroptosis while highlighting recent advances understanding mechanistic involvement NAFLD/NASH.
Язык: Английский
Процитировано
7
Journal of Clinical and Translational Hepatology, Год журнала: 2025, Номер 000(000), С. 000 - 000
Опубликована: Янв. 22, 2025
Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty and nucleotides. To date, more than fifty SLC transporter subfamilies have been identified, many of which linked to the progression hepatic steatosis fibrosis. These conditions often caused by factors such as non-alcoholic liver disease steatohepatitis, major contributors global burden. The activity members regulates transport substrates across biological membranes, playing key roles in lipid synthesis metabolism, mitochondrial function, ferroptosis. processes, turn, influence function hepatocytes, stellate cells, macrophages, thereby contributing development Additionally, some involved drug transport, acting critical regulators drug-induced steatosis. Beyond substrate certain also exhibit additional functions. Given pivotal role fibrosis, this review aimed summarize molecular mechanisms through these conditions.
Язык: Английский
Процитировано
1
Biogerontology, Год журнала: 2024, Номер 26(1)
Опубликована: Ноя. 15, 2024
Язык: Английский
Процитировано
6
Antioxidants, Год журнала: 2024, Номер 13(6), С. 729 - 729
Опубликована: Июнь 15, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. MASLD and its advanced-stage fibrosis cirrhosis are leading causes failure liver-related death worldwide. Mitochondria crucial organelles in cells for energy generation oxidative metabolism fatty acids carbohydrates. Recently, mitochondrial dysfunction has been shown to play a vital role pathogenesis fibrosis. Mitophagy, selective form autophagy, removes recycles impaired mitochondria. Although significant advances have made understanding mitophagy diseases, adequate summaries concerning contribution cell lacking. This review will clarify mechanism development fibrosis, including hepatocytes, macrophages, hepatic stellate cells, sinusoidal endothelial cells. In addition, therapeutic strategies or compounds related also summarized. conclusion, mitophagy-related might be translational clinical treatment
Язык: Английский
Процитировано
4
International Immunopharmacology, Год журнала: 2025, Номер 147, С. 114019 - 114019
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 11, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD; formerly known as non-alcoholic fatty disease, NAFLD) has become one of the most prevalent chronic diseases worldwide, with its incidence continuously rising alongside epidemic metabolic disorders. AMP-activated protein kinase (AMPK), a key regulator cellular energy metabolism, influences multiple pathological processes associated MASLD. This review systematically summarizes regulatory roles AMPK in lipid inflammatory response, cell apoptosis, and fibrosis. Additionally, it discusses latest developments activators from preclinical to clinical studies, while analyzing major challenges currently faced potential strategies for resolution. A deeper understanding mechanisms will contribute development more effective therapeutic approaches
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 28, 2025
Hypertrophic Scar (HS) is a common fibrotic disease of the skin, usually caused by injury to deep dermis due trauma, burns, or surgical injury. The main feature HS thickening and hardening often accompanied itching pain, which seriously affects patient's quality life. Macrophages are involved in all stages genesis through phenotypic changes. M1-type macrophages primarily function early inflammatory phase secreting pro-inflammatory factors, while M2-type actively contribute tissue repair fibrosis. Despite advances understanding pathogenesis, precise mechanisms linking macrophage changes fibrosis remain incompletely elucidated. This review addresses these gaps discussing pathological formation, at different pathways influence progression. Furthermore, emerging technologies for treatment novel therapeutic strategies targeting highlighted, offering potential avenues improved prevention HS.
Язык: Английский
Процитировано
0