Machine Learning and Experimental Validation Identified Ferroptosis Signature and Innovative Biomarkers (ESR1 and GSTZ1) in Liver Fibrosis DOI Creative Commons
Wen Luo,

Hong-Wen Wu,

Zhijie Yang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10313 - 10332

Published: Dec. 1, 2024

Background: Targeting ferroptosis is an effective approach to mitigate hepatic fibrosis, yet no reports exist on the signature in liver fibrosis. This study aimed explore characteristics this disease. Methods: RNAseq data from GSE6764, GSE188604 and Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) were downloaded. Multiple machine learning methods, including Weighted Gene Co-expression Network Analysis (WGCNA), Random Forest (RF) Support Vector Machine (SVM), used identify core genes fibrosis ferroptosis. WGCNA can pinpoint modules linked clinical traits, aiding discovering diagnostic progression molecules complex diseases. RF SVM are often utilized for validation boost result accuracy. Carbon tetrachloride (CCl4) was establish a mouse model validate gene expression, which also assessed test GEO datasets. Finally, role of hepatocellular carcinoma (HCC) investigated using ROC analysis. Results: methods screened nine genes, IL1B, GSTZ1, LIFR, SLC25A37, PTGS2, MT1G, HSPB1, ESR1, PHGDH. In vivo experimental validation, RT-PCR showed ESR1 GSTZ1 significantly under-expressed group compared normal group. Simultaneously, GSE6764 GSE188604, identified as protective More in-depth research found that exhibited good performance both HCC, suggesting persistent decrease patients might signal HCC. Conclusion: The present first report identifies two novel biomarkers, providing new insights diagnosis treatment future. Keywords: ferroptosis, biomarker

Language: Английский

Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseases DOI Creative Commons
Junmin Wang, Ning Ding, Chong Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 21, 2025

Adropin is a secreted peptide encoded by the energy homeostasis-associated gene (ENHO), located chromosome 9p13.3, with conserved amino acid sequence across humans and mice. Its expression regulated various factors, including fat, LXRα, ERα, ROR, STAT3. plays critical role in glucose lipid metabolism, as well insulin resistance, modulating multiple signaling pathways that contribute to reduction of obesity improvement blood homeostasis. Additionally, it influences immune cells inflammation, exerting anti-inflammatory effects diseases. While extensive research has summarized regulation cellular metabolism adropin, limited studies have explored its inflammation. To enhance understanding adropin’s immune-modulating mechanisms, this review synthesizes recent findings on conditions such atherosclerosis, diabetes, fatty liver, non-alcoholic hepatitis, Furthermore, discusses current limitations outlines potential future directions for adropin-related investigations. It hoped ongoing into adropin will significantly advancement medical treatments

Language: Английский

Citations

1
TJ0113 attenuates fibrosis in metabolic dysfunction-associated steatohepatitis by inducing mitophagy DOI
Chun-Lian Huang,

Shen Qi-En,

Xufeng Cen

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114678 - 114678

Published: April 18, 2025

Language: Английский

Citations

1
Unveiling the role of ferroptosis in the progression from NAFLD to NASH: recent advances in mechanistic understanding DOI Creative Commons

Qian Yu,

Lixing Song

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

Non-alcoholic fatty liver disease (NAFLD) is a prevalent and significant global public health issue. Nonalcoholic steatohepatitis (NASH) represents an advanced stage of NAFLD in terms pathology. However, the intricate mechanisms underlying progression from to NASH remain elusive. Ferroptosis, characterized by iron-dependent cell death distinguished other forms based on morphological, biochemical, genetic criteria, has emerged as potential participant with pivotal role driving progression. Nevertheless, its precise mechanism remains poorly elucidated. In this review article, we comprehensively summarize pathogenesis NAFLD/NASH ferroptosis while highlighting recent advances understanding mechanistic involvement NAFLD/NASH.

Language: Английский

Citations

7
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4 DOI Creative Commons

Yuanfang Guo,

Jie Wang, Dongmei Zhang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
SLC7A11 suppresses pyroptosis to alleviate rheumatoid arthritis development by modulating the IL-17 pathway DOI

Shaojian Chen,

Liang Zou, Liangzong Huang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114019 - 114019

Published: Jan. 10, 2025

Language: Английский

Citations

0
The Role of Solute Carrier Family Transporters in Hepatic Steatosis and Hepatic Fibrosis DOI Open Access
Chi Zhang,

X Yang,

Yi Xue

et al.

Journal of Clinical and Translational Hepatology, Journal Year: 2025, Volume and Issue: 000(000), P. 000 - 000

Published: Jan. 22, 2025

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty and nucleotides. To date, more than fifty SLC transporter subfamilies have been identified, many of which linked to the progression hepatic steatosis fibrosis. These conditions often caused by factors such as non-alcoholic liver disease steatohepatitis, major contributors global burden. The activity members regulates transport substrates across biological membranes, playing key roles in lipid synthesis metabolism, mitochondrial function, ferroptosis. processes, turn, influence function hepatocytes, stellate cells, macrophages, thereby contributing development Additionally, some involved drug transport, acting critical regulators drug-induced steatosis. Beyond substrate certain also exhibit additional functions. Given pivotal role fibrosis, this review aimed summarize molecular mechanisms through these conditions.

Language: Английский

Citations

0
The role of macrophages in hypertrophic scarring: molecular to therapeutic insights DOI Creative Commons

L Shen,

Yao Zhou, Jie Gong

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

Hypertrophic Scar (HS) is a common fibrotic disease of the skin, usually caused by injury to deep dermis due trauma, burns, or surgical injury. The main feature HS thickening and hardening often accompanied itching pain, which seriously affects patient's quality life. Macrophages are involved in all stages genesis through phenotypic changes. M1-type macrophages primarily function early inflammatory phase secreting pro-inflammatory factors, while M2-type actively contribute tissue repair fibrosis. Despite advances understanding pathogenesis, precise mechanisms linking macrophage changes fibrosis remain incompletely elucidated. This review addresses these gaps discussing pathological formation, at different pathways influence progression. Furthermore, emerging technologies for treatment novel therapeutic strategies targeting highlighted, offering potential avenues improved prevention HS.

Language: Английский

Citations

0
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD DOI
Xavier Palomer,

Jue-Rui Wang,

Claudia Escalona

et al.

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis DOI
Waleed Hassan Almalki, Salem Salman Almujri

Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 15, 2024

Language: Английский

Citations

3
Research progress on AMPK in the pathogenesis and treatment of MASLD DOI Creative Commons
Jiang Feng, Menghuan Li, Tingting Yao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 11, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD; formerly known as non-alcoholic fatty disease, NAFLD) has become one of the most prevalent chronic diseases worldwide, with its incidence continuously rising alongside epidemic metabolic disorders. AMP-activated protein kinase (AMPK), a key regulator cellular energy metabolism, influences multiple pathological processes associated MASLD. This review systematically summarizes regulatory roles AMPK in lipid inflammatory response, cell apoptosis, and fibrosis. Additionally, it discusses latest developments activators from preclinical to clinical studies, while analyzing major challenges currently faced potential strategies for resolution. A deeper understanding mechanisms will contribute development more effective therapeutic approaches

Language: Английский

Citations

0