Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 6, 2025

Muscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle index (ASMI) and phenotypic age(PhenoAge), while examining mediating of systemic inflammation. The analysis included 7,440 participants from NHANES 2011-2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as residuals regressing PhenoAge on chronological age. Multivariable linear regression analyses were performed assess ASMI PhenoAgeAccel. Mediation conducted quantify extent which inflammation contributes this association. Our revealed that higher is linked slower aging, evidenced by lower PhenoAgeAccel (β = -0.48, 95% CI: -0.66 -0.29, p 0.0001). Systemic partially mediated effect, with mediation proportion 35.1%. varied notably across demographic health-related subgroups, being particularly significant females, individuals obesity, those physical activity. These findings highlight critical importance slowing emerging key mediator. public implications are substantial, suggesting targeted interventions-such resistance training, anti-inflammatory diets, personalized medical approaches-could play decelerating improving long-term outcomes.

Язык: Английский

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Red blood cell distribution width to albumin ratio (RAR) is associated with low cognitive performance in American older adults: NHANES 2011–2014

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Март 7, 2025

The red blood cell distribution width to albumin ratio (RAR) is a novel comprehensive biomarker of inflammation and nutrition, which has emerged as reliable prognostic indicator for adverse outcomes mortality in patients with various diseases. However, the association between RAR low cognitive performance older adults remains unclear. This study aims investigate relationship among United States. study, retrospective analysis, included 2,765 participants aged 60 years from National Health Nutrition Examination Survey (NHANES) conducted 2011 2014. Low was assessed using word learning subset Consortium Establish Registry Alzheimer's Disease (CERAD), Digit Symbol Substitution Test (DSST), Animal Fluency (AFT). defined scores below lowest quartile each test. evaluated weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses. After adjusting all potential confounders, independently linearly positively associated both DSST AFT performance. Specifically, compared first RAR, those fourth had adjusted ORs (95% CIs) 1.81 (1.03, 3.20) 1.68 (1.05, 2.67) Subgroup analysis did not reveal significant interactions stratification variables. significantly Maintaining lower may be crucial strategy mitigating risk decline elderly population.

Язык: Английский

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Exploring the association between dietary indices and metabolic dysfunction-associated steatotic liver disease: Mediation analysis and evidence from NHANES

PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0321251 - e0321251

Опубликована: Апрель 17, 2025

Background The association between dietary indices and metabolic dysfunction-associated steatotic liver disease (MASLD) has shown inconsistent results in previous studies. Additionally, the potential mediating variables linking quality to MASLD have not been adequately explored. Methods We analyzed data from 6,369 participants National Health Nutrition Examination Survey (NHANES) 2007–2018. Three indices—Healthy Eating Index (HEI), Energy-adjusted Dietary Inflammatory (EDII), Composite Antioxidant (CDAI)—were evaluated for their associations with using logistic regression models adjusted a comprehensive range of covariates. Mediation analysis was performed evaluate roles mediators four domains: insulin resistance (homeostatic model assessment resistance, HOMA-IR; score METS-IR), systemic inflammation (systemic inflammatory response index, SIRI; immune-inflammation SII), obesity or visceral fat distribution (a body shape ABSI; roundness BRI), oxidative stress (Gamma-Glutamyltransferase, GGT; Bilirubin; Uric Acid). Results After adjusting all covariates, only HEI showed consistent inverse MASLD, while EDII CDAI no significant associations. identified METS-IR, HOMA-IR, BRI, ABSI as relationship mediation proportion accounting 47.16%, 48.84%, 52.69%, 13.84%, respectively. Conclusion Higher is associated reduced risk MASLD. findings suggest that partially mediate providing insights into mechanisms diet health.

Язык: Английский

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Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 25, 2025

Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker dyslipidemia. However, whether AIP can be used as indicator aging remains unclear. This study aims investigate the relationship between US adult population. 4,471 American adults with age over 20 years National Health Nutrition Examination Survey (NHANES) database were included this study. Biological was assessed by phenotypic acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses interaction tests employed explore association PhenoAgeAccel. Furthermore, adjusted restricted cubic spline (RCS) assess potential nonlinear relationships, while mediation analysis utilized identify mediating effects homeostatic model assessment insulin resistance (HOMA-IR). Besides, network pharmacology performed determine mechanisms underlying dyslipidemia-related acceleration. A total participants study, median chronological age, PhenoAge PhenoAgeAccel for overall population 49 (35-64) years, 42.85 (27.30-59.68) - 6.92 (- 10.52 -2.46) respectively. In fully model, one unit increase correlated 1.820-year (β = 1.820, 95% CI: 1.085-2.556), which more pronounced among individuals being female, diabetic hypertensive. RCS revealed PhenoAgeAccel, inflection point identified at -0.043 via threshold saturation effect analysis. demonstrated positive correlation both before 6.550, 5.070-8.030) after 3.898, 2.474-5.322) point. Additionally, HOMA-IR found mediate 39.21% Finally, INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A, SERPINE1 core targets aging, functionally linked key signaling pathways like AMPK, apelin, JAK-STAT, FoxO, etc. CONCLUSIONS: An elevated notably positively accelerated suggesting that may serve predictor evaluate

Язык: Английский

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Combined healthy lifestyle behaviors and all-cause mortality risk in middle-aged and older US adults: A Longitudinal Cohort Study

Archives of Gerontology and Geriatrics, Год журнала: 2024, Номер 130, С. 105702 - 105702

Опубликована: Ноя. 24, 2024

Язык: Английский

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DNA methylation-based telomere length is more strongly associated with cardiovascular disease and long-term mortality than quantitative polymerase chain reaction-based telomere length: evidence from the NHANES 1999–2002

Clinical Epigenetics, Год журнала: 2024, Номер 16(1)

Опубликована: Дек. 4, 2024

Telomere length (TL) serves as a pivotal gauge of cellular aging, with shorter TL linked to various age-related ailments. Recently, DNA methylation-based estimator, known DNAmTL, has emerged novel measurement tool. Our current investigation scrutinized the correlation between DNAmTL and risks cardiovascular disease (CVD) enduring mortality among middle-aged elderly individuals. We enrolled nationwide, population-based cohort subjects from National Health Nutrition Examination Survey spanning 1999 2002, possessing data on both quantitative polymerase chain reaction-based (qPCRTL). Logistic regression models Cox proportional hazards were employed evaluate associations CVD risk mortality, respectively. The comprised 2532 participants, weighted prevalence 19.06%. Notably, each one-kilobase increase in was 53% diminished [odds ratio (OR): 0.47, 95% confidence interval (CI): 0.23–0.95, P = 0.035]. Over median follow-up period 206 months, 1361 deaths recorded (53.75%), 590 (23.30%) ascribable CVD. Individuals lengthiest exhibited 36% lower all-cause (hazard (HR): 0.64, CI: 0.49–0.85, 0.002) 35% decrease (HR: 0.65, 0.43–0.98, 0.044) compared those shortest DNAmTL. stronger association age observed for qPCRTL (r -0.58 vs. r − 0.25). Analysis receiver operating characteristic (ROC) curves suggested superior predictive performance over (area under curve (AUC): 0.63 0.55, < 0.001), (AUC: 0.74 0.62, 0.75 0.001). Longer positively correlated reduced long-term cohorts. outperformed an aging biomarker stratification mortality.

Язык: Английский

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Optimal lifestyle patterns for delaying ageing and reducing all-cause mortality: insights from the UK Biobank

European Review of Aging and Physical Activity, Год журнала: 2024, Номер 21(1)

Опубликована: Окт. 5, 2024

Язык: Английский

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Health effects of mixed metal exposure on accelerating aging among the elderly population

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117760 - 117760

Опубликована: Фев. 1, 2025

Human exposure to heavy metals occurs through multiple pathways in daily life. However, the effects of mixed metal on accelerated aging elderly U.S. population remains unclear. This study aims investigate association between concentrations blood and urine onset aging. A total 2530 individuals were included analysis 716 this study. GrimAge acceleration (AgeAccelGrim) was calculated as residuals from regressing DNA methylation chronological age. Weighted multivariable logistic regression models applied analyze relationship with AgeAccelGrim. Bayesian kernel machine (BKMR) performed estimate individual or mixtures We found that cadmium (Cd) concentration positively associated an increased risk AgeAccelGrim both females males, odds ratios (OR) 5.73 (95 % confidence interval CI): 1.88-17.41, P trend = 0.008) 14.25 CI: 4.88-41.62, < 0.001), respectively. Moreover, these associations more pronounced for urinary Cd compared Cd. Blood lead (Pb) also a 3.52-fold 1.21-10.24, 0.007) increase among males. BKMR confirmed aforementioned findings, identifying most significant contributor Exposure metals, either individually mixture, biological These

Язык: Английский

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Association of phenotypic age acceleration with all-cause and cause-specific mortality among U.S. cancer survivors: a retrospective cohort study

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 25, 2025

Cancer survivors may experience accelerated biological aging, increasing their risk of mortality. However, the association between phenotypic age acceleration (PAA) and mortality among cancer remains unclear. This study aimed to evaluate relationship PAA all-cause mortality, cancer-specific non-cancer adult in United States. We utilized data from National Health Nutrition Examination Survey (NHANES) 1999 2018, including 2,643 (unweighted) patients aged ≥ 20 years. Phenotypic was calculated using ten physiological biomarkers, residuals regressing on chronological (age residuals, AAR) were used determine status. Participants divided into without groups based sign residuals. Weighted Cox proportional hazards regression models assess adjusting for demographic characteristics, lifestyle factors, comorbidities. Restricted cubic spline (RCS) employed explore dose-response AAR Over a median follow-up 9.16 years, 991 participants died. After multiple covariates, significantly associated with increased risks (HR = 2.07; 95% CI: 1.69–2.54), 2.15; 1.52–3.04), 2.06; 1.66–2.57). Each one-unit increase 4% all-cause, cancer-specific, 1.04; 1.03–1.05). RCS indicated linear Among U.S. survivors, is serve as an important biomarker predicting prognosis survivors.

Язык: Английский

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Association of 25-hydroxyvitamin D and physical activity with oral care needs among older U.S. adults

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 8, 2025

Язык: Английский

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