Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications
Rebecca Seitz,
Deniz Tümen,
C Kunst
и другие.
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1078 - 1078
Опубликована: Сен. 4, 2024
Cells
constantly
face
the
challenge
of
managing
oxidants.
In
aerobic
organisms,
oxygen
(O
Язык: Английский
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata
Carbohydrate Polymers,
Год журнала:
2025,
Номер
356, С. 123381 - 123381
Опубликована: Фев. 14, 2025
Язык: Английский
PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 21, 2025
Aging
is
characterized
by
cellular
degeneration
and
impaired
physiological
functions,
leading
to
a
decline
in
male
sexual
desire
reproductive
capacity.
Oxidative
stress
(OS)
lead
testicular
aging
impairing
the
system,
but
potential
mechanisms
remain
unclear.
In
present
study,
functional
status
of
tissues
from
young
aged
boars
was
compared,
transcriptional
responses
Leydig
cells
(LCs)
hydrogen
peroxide
(H2O2)-induced
senescence
were
explored,
revealing
role
OS
promoting
system.
601
differentially
expressed
genes
(DEGs)
associated
with
OS,
cell
cycle
regulation,
intracellular
processes
identified.
These
DEGs
significantly
enriched
critical
pathways,
including
p53
signaling
pathway,
autophagy,
senescence.
Protein-protein
interaction
(PPI)
network
analysis
unveiled
15
key
related
DNA
replication,
polo-like
kinase
3
(PLK3)
exhibiting
increased
expression
under
OS.
vitro,
PLK3
knockdown
enhanced
viability
antioxidant
capacity
LCs
This
study
deepens
our
understanding
how
respond
provides
new
therapeutic
targets
for
enhancing
resistance
oxidative
damage
tissue
health.
Язык: Английский
Extracellular vesicles within a tumourigenic therapy-induced senescent tumour secretome are able to confer anti-cancer properties
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 29, 2024
ABSTRACT
Triple-negative
breast
cancers
(TNBC),
associated
with
poor
prognosis
and
high
tumour
recurrence,
are
often-treated
taxanes
in
first-line
treatment
regimens.
However,
acquired
disease
resistance
can
often
set
in,
hampering
clinical
efficacy.
One
avenue
that
could
engender
therapy
is
therapy-induced
senescence
(TIS),
as
they
represent
a
population
of
residual
highly
secretory.
Although
it
known
TIS
contribute
to
development
via
the
secretome,
underlying
molecular
mechanisms
not
fully
understood.
In
this
study,
we
sought
dissect
role
TNBC-derived
TIS-associated
secretome
chemoresponse.
We
found
paclitaxel-treated
cells
induced
mitotic
slippage
entered
tetraploid
cells.
The
SASP
was
be
enriched
soluble
cytokines
other
pro-tumorigenic
factors
linked
recurrence
distant
metastasis.
Interestingly,
senescence-associated
small
extracellular
vesicles
(sEVs)
or
exosomes,
an
underappreciated
component
SASP,
increased
genomic
instability,
ROS
anti-tumour
activity.
Exosomal
proteomic
transcriptomic
profiling
further
revealed
DKK1,
negative
regulator
WNT
signalling,
TIS-sEVs.
Further
investigation
demonstrated
DKK1-control
inflammatory
production
confer
reduced
activity
recipient
TNBC
cancer
Taken
together,
study
unexpected
findings
where
TIS-sEVs
opposing
tumourigenic
outcomes
elicited
by
TIS-SASP,
indicating
sEVs
should
considered
distinct
entities.
Язык: Английский
Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities
MedComm – Oncology,
Год журнала:
2024,
Номер
3(4)
Опубликована: Дек. 1, 2024
Abstract
Oxidative
stress
results
from
an
imbalance
between
the
production
and
neutralization
of
reactive
oxygen
species.
It
induces
oxidative
damage
to
cellular
components
including
proteins,
lipids,
nucleic
acids,
membranes,
therefore
intrinsically
linking
aging‐related
diseases
such
as
cancer,
cardiovascular
disease,
neurological
disorders.
Emerging
evidence
suggests
that
may
promote
tumor
development
by
influencing
various
aspects
senescence,
its
onset,
pro‐inflammatory
secretion,
alteration
function
structure.
Modulating
target
senescence
offers
a
novel
strategy
for
cancer
prevention
treatment.
However,
thorough
grasp
specific
mechanisms
at
play
is
lacking.
This
review
will
present
association
their
regulatory
role
in
progression
treatment,
with
emphasis
on
senescence‐associated
secretory
phenotype,
immunosenescence
therapy‐induced
senescence.
Current
agents
strategies
remove
side
effects
via
killing
senescent
cells
or
modulating
improve
antitumor
efficacy
be
summarized.
help
readers
better
understand
complex
relationship
also
provide
basis
further
research
this
area.
Язык: Английский