The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007–2010

International Journal of COPD, Год журнала: 2025, Номер Volume 20, С. 159 - 169

Опубликована: Янв. 1, 2025

Purpose:The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a newly developed biomarker that combines measurements of CRP, serum albumin, and lymphocyte count.This provides thorough assessment patient's inflammation level, nutritional condition, immunological function.The objective this study to examine the correlation between CALLY all-cause mortality in COPD patients.Methods: We calculated using data from National Health Nutrition Examination Survey (NHANES) for 2007-2008 2009-2010 cycles, extracted participants' peripheral blood samples.The utilized Kaplan-Meier curves, restricted cubic spline (RCS) Cox regression analysis evaluate relationship risk patients.To assess predictive accuracy index, we area under receiver operating characteristic (ROC) curve (AUC). Results:The included 1,048 participants found significant negative patients with COPD.The was major predictor survival [fully adjusted model: 3rd quartile, HR = 1.61, 95% CI: 1.02-2.52,p 0.039; 2nd 2.11, 1.22-3.65,p 0.008; 1st 3.12, 2.00-4.85,p < 0.001].The RCS curves demonstrated non-linear association patients.The areas (AUC) predicting 5-and 10-year were 0.693 0.656. Conclusion:The has strong US could serve as prognostic these patients.

Язык: Английский

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Associations of dietary inflammation index and composite dietary antioxidant index with all-cause mortality in COPD patients

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 21, 2025

Background Few studies have investigated the effects of both dietary inflammatory index (DII) and composite antioxidant (CDAI) on mortality in patients with Chronic Obstructive Pulmonary Disease (COPD). Our research aimed to explore associations between two indicators all-cause COPD patients. Methods We conducted a prospective cohort analysis based data from six cycles National Health Nutrition Examination Survey (NHANES) dataset 2007 2018. Multivariate Cox proportional hazard models were used analyze DII CDAI COPD. employed restricted cubic spline (RCS) examine dose–response relationship mortality, threshold effect determine inflection point, subgroup interaction tests verify stability results. Results A total 1,457 aged over 40 enrolled study. The median follow-up time was 76.8 months. multivariate hazards model showed that increased associated an increase (HR (95% CI): 1.11(1.04, 1.18), p = 0.002). In contrast, negatively correlated 0.95(0.91, 0.99), 0.01). RCS nonlinear correlation or mortality. maximum pro-inflammatory point 2.32, while is −0.12. Subgroup analyses indicated exposure variables stable most populations. Conclusion Reducing diet increasing can reduce

Язык: Английский

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Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 25, 2025

Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker dyslipidemia. However, whether AIP can be used as indicator aging remains unclear. This study aims investigate the relationship between US adult population. 4,471 American adults with age over 20 years National Health Nutrition Examination Survey (NHANES) database were included this study. Biological was assessed by phenotypic acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses interaction tests employed explore association PhenoAgeAccel. Furthermore, adjusted restricted cubic spline (RCS) assess potential nonlinear relationships, while mediation analysis utilized identify mediating effects homeostatic model assessment insulin resistance (HOMA-IR). Besides, network pharmacology performed determine mechanisms underlying dyslipidemia-related acceleration. A total participants study, median chronological age, PhenoAge PhenoAgeAccel for overall population 49 (35-64) years, 42.85 (27.30-59.68) - 6.92 (- 10.52 -2.46) respectively. In fully model, one unit increase correlated 1.820-year (β = 1.820, 95% CI: 1.085-2.556), which more pronounced among individuals being female, diabetic hypertensive. RCS revealed PhenoAgeAccel, inflection point identified at -0.043 via threshold saturation effect analysis. demonstrated positive correlation both before 6.550, 5.070-8.030) after 3.898, 2.474-5.322) point. Additionally, HOMA-IR found mediate 39.21% Finally, INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A, SERPINE1 core targets aging, functionally linked key signaling pathways like AMPK, apelin, JAK-STAT, FoxO, etc. CONCLUSIONS: An elevated notably positively accelerated suggesting that may serve predictor evaluate

Язык: Английский

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Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 29, 2025

Background Preserved ratio impaired spirometry (PRISm) represents an abnormal lung function state distinct from traditional chronic obstructive pulmonary disease, characterized by unique clinical and epidemiological features. PRISm has been associated with various health issues, including increased risk of metabolic disorders cardiovascular diseases. Vitamin D, known for its anti-inflammatory, immunomodulatory, antioxidant properties, may play a role in reducing the PRISm. This study aims to investigate relationship between vitamin D levels PRISm, mediating effects systemic inflammation markers indicators population U.S. adults. Methods cross-sectional analyzed data 17,333 participants National Health Nutrition Examination Survey, 1,577 individuals 15,756 without. Baseline characteristics were assessed, multivariate logistic regression models employed examine Mediation analysis was conducted explore potential roles immune-inflammation index (SII), triglyceride-glucose (TyG) index, bilirubin. Nonlinear relationships assessed using restricted cubic spline (RCS) models. Results The group had lower median inflammatory profiles compared non-PRISm group. Multivariate confirmed inverse association (adjusted OR: 0.989, 95% CI: 0.984–0.994, p &lt; 0.001). RCS showed nonlinear protective effect stabilizing at above 50 nmol/mL. highlighted bilirubin as positive mediator (ACME = −4.11 × 10 −5 , 0.001), while TyG demonstrated suppressive mediation 2.68 SII did not show significant mediation. Conclusion Elevated are linked potentially acting this relationship. underscores significance maintaining sufficient promote mitigate prevalence among Further research is warranted personalized supplementation strategies preventive approach.

Язык: Английский

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Associations between ultra-processed foods intake and preserved ratio impaired spirometry in U.S. adults

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 31, 2025

Preserved Ratio Impaired Spirometry (PRISm) is increasingly recognized as a precursor to Chronic Obstructive Pulmonary Disease (COPD). The impact of Ultra-Processed Foods (UPFs) intake on PRISm and lung function remains underexplored, we aimed explore their associations. This study included 8,336 U.S. adults. Weighted logistic linear regression models were employed for main analysis. Dose-response relationship was examined through restricted cubic spline (RCS) analysis, subgroup analyses explored interactions with selected covariates. Participants in the group older exhibited various adverse health characteristics. percentage total daily energy from UPFs (%Kcal) associated non-significant increase risk (OR 1.67, 95% CI: 0.96-2.92, p = 0.07). However, highest quartile significantly linked increased 1.36, 0.99-1.86, P trend 0.043). Furthermore, higher negatively affected function, participants showing significant reduction forced expiratory volume 1 s (FEV1) -45.5 mL (95% -87.6 -3.4, 0.045) decrease vital capacity (FVC) -139.4 -223.5 -55.4, < 0.001) compared those lowest quartile. RCS analysis demonstrated relationships both function. Subgroup revealed susceptibility primarily among individuals occupational exposure. Additionally, sensitivity indicated that (%Grams) an 1.86, 1.07-3.25, 0.03). Higher affects particularly

Язык: Английский

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Interactions of physical activity and lung function on cognitive health in older adults: Joint association and mediation analysis

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100090 - 100090

Опубликована: Фев. 1, 2025

Maintaining cognitive health in old adults has become a significant public challenge, with lung function and physical activity (PA) as essential modifiable factors. However, the joint mediation effects of these two factors cognition remain unclear. This study assesses association PA cognition. We utilized cross-sectional data from 2011-2012 U.S. National Health Nutrition Examination Survey, including aged 60-79 assessed for function, PA, Lung included forced expiratory volume one second (FEV1), vital capacity (FVC), peak flow (PEF) FEV1/FVC. was using Global Physical Activity Questionnaire, covering occupational (OPA), transportation-related (TPA), leisure-time (LTPA). Cognition evaluated Digit Symbol Substitution Test, Animal Fluency Delayed Recall Test Immediate Test. Weighted multiple linear regression models were used to analyze separate associations cognition, while also exploring potential between A total 927 participants, representing 35,525,782 residents, included, weighted median age 65 (IQR, 63 -71) years, 53.6 % female. The results showed positive FEV1, FVC, PEF all positively correlated, FEV1/FVC no notable link. Further analysis revealed best performance observed participants active LTPA highest quartile indicating Mediation indicated that mediated 24.1 (95 %CI: 6.3 - 47.0 %, P = 0.03) relationship 10.2 0.5 27.0 0.04) function. may have bidirectional relationship. combination better strongly associated higher highlighting need strengthen exercise focused on maintain older adults.

Язык: Английский

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Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 18, 2025

In the US, most common type of cancer and second leading cause cancer-related death in men is prostate (PCa). Food lifestyle factors may influence risk developing cancer. Therefore, research on dietary components associated with essential for its prevention. Data from National Health Nutrition Examination Survey (NHANES) between 2003 2010 was used this cross-sectional investigation involving 5,658 middle-aged older American men. Dietary antioxidant vitamins A, C, E, total carotenoids, zinc, selenium were subtracted mean, divided by standard deviation, respectively, then summed to become CDAI. Participants categorized as high PCa if they had tPSA greater than 10 ng/mL or levels 4 f/t PSA ratios 25% below; remaining subjects classified being at low PCa. The sample represented approximately 75,984,602 After multivariate logistic regression, dose-effect analysis stratified analysis, CDAI significantly linearly negatively a (OR=0.95, P=0.002, P linear=0.0021). Age moderation showed significant effect inverse relationship (B = -0.0097, SE 0.0034, t -2.85, 0.004). Among independent effects components, zinc more strongly (zinc, OR 0.80, 0.008; selenium, 0.78, P< 0.001). serves indicator men, intake has protective risk, especially population

Язык: Английский

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Association between the composite dietary antioxidant index and sarcopenia risk in American adults: a cross-sectional NHANES study

BMJ Public Health, Год журнала: 2025, Номер 3(1), С. e001447 - e001447

Опубликована: Март 1, 2025

Background Given the absence of specific pharmacological treatments for sarcopenia, identifying effective lifestyle and dietary interventions is imperative. This study aims to explore association between composite antioxidant index (CDAI) offering new insights into nutritional strategies sarcopenia-prone populations. Methods cross-sectional analysed secondary data from National Health Nutrition Examination Survey cycles spanning 2001–2006 2011–2018. Weighted multivariate logistic regression restricted cubic spline (RCS) analyses were employed evaluate non-linear CDAI sarcopenia perform stratified analyses. Results In this study, encompassing 19 683 American adults, representative national population 132 140 502 residents, 7.97% diagnosed with sarcopenia. Across all adjusted models, a higher was inversely associated risk (OR 0.94, 95% CI 0.92, 0.96; P <0.0001). The highest quartile scores those in lowest revealed significantly reduced odds 0.46, 0.38, 0.56; RCS analysis demonstrated relationship Additionally, indicated that inverse more pronounced among participants educational levels tumours. Conclusions There negative prevalence suggesting may help managing preventing occurrence

Язык: Английский

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Predictive Value of Dietary Inflammatory Index for Recurrence of Plaque Psoriasis—A Retrospective Study

British Journal of Hospital Medicine, Год журнала: 2025, Номер 86(3), С. 1 - 12

Опубликована: Март 26, 2025

Aims/Background Determining the predictive value of dietary inflammatory index on recurrence plaque psoriasis vulgaris is an emerging research area. This study aims to investigate (DII) for psoriasis. Methods A retrospective was conducted 200 patients with who were treated at China-Japan Friendship Hospital from October 2022 December 2023. Patients divided into group (n = 95) and non-recurrence 105) based whether they had experienced a during follow-up. Univariate multivariate logistic regression analyses performed determine influencing factors recurrence. The receiver operating characteristic (ROC) curve used evaluate DII Results Comparisons age, gender, Drinking, duration illness, family history, season onset, history skin allergies showed no statistically significant differences between (p > 0.05). However, comparisons sleep inadequacy, anxiety, smoking, infections, < results analysis indicated that independent ROC predicted area under in predicting 0.815, standard error 0.031 (95% confidence interval (CI): 0.754–0.877, p 0.001) Youden’s 0.60, sensitivity 74.7%, specificity 84.8%. has highest value. Conclusion Characterized by high analysis, exhibits

Язык: Английский

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Association of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) with COPD prevalence and all-cause mortality: a population-based study based on NHANES 2007–2016

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 3, 2025

The non-high-density lipoprotein cholesterol to high-density ratio (NHHR) plays a potential role in metabolic and cardiovascular diseases. However, its association with chronic obstructive pulmonary disease (COPD) is not well-defined. Here, we aim investigate the of NHHR both prevalence COPD all-cause mortality among individuals COPD. This population-based NHANES (2007-2016) study utilized weighted statistical analyses. Multivariable logistic regression assessed NHHR-COPD association, restricted cubic spline (RCS) testing for non-linearity. between was evaluated using Cox proportional hazards models Kaplan-Meier, RCS Subgroup sensitivity analyses confirmed findings' reliability. included 6349 participants, whom 1271 were diagnosed Participants highest tertile demonstrated 62% higher odds compared those lowest (OR = 1.62, 95% CI:1.11-2.39, P 0.017). Results from analysis indicated nonlinear relationship (P 0.007), curve demonstrating an inverted L-shape. Over average follow-up period 93 months, 320 participants died. In Kaplan-Meier survival analysis, lower greater cumulative probability tertiles < 0.001). Weighted multivariable revealed inverse levels mortality, showing 11% likelihood relative (HR 0.89, CI:0.80-0.99, 0.027). addition, significant negative linear patients 0.081). further associations on morbidity mortality. Higher associated increased yet inversely correlated patients. These paradoxical underscore need COPD-specific lipid management strategies that balance progression risks.

Язык: Английский

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