Rapid Microwave‐Assisted Synthesis of Nitrogen‐Doped Carbon Quantum Dots as Fluorescent Nanoprobe for Sensitive Estimation of Tizanidine in Human Urine and Dosage Forms: Application to Content Uniformity Testing
Luminescence,
Год журнала:
2025,
Номер
40(4)
Опубликована: Апрель 1, 2025
This
study
introduces
a
novel
sensitive
and
environment-friendly
spectrofluorimetric
method
for
determination
of
an
important
muscle
relaxant
drug,
tizanidine,
with
no
need
using
organic
solvents
or
any
pre-derivatization
steps.
strategy
depends
on
tizanidine
quenching
effect
the
native
fluorescence
newly
synthesized
nitrogen-doped
carbon
quantum
dots
(N-CQDs)
from
Tetraclinis
articulata
extract,
first
time,
microwave-assisted
synthetic
in
only
4
min.
Full
characterization
N-CQDs
was
performed
by
different
microscopic
spectroscopic
techniques.
The
showed
good
emission
at
380
nm
when
excited
312
nm.
is
one
analysis
spectrofluorimetrically
as
nanosensors.
developed
approach
demonstrated
linearity
within
range
0.1-1.0
μg/mL
correlation
coefficient
0.9997
detection
limit
0.024
μg/mL.
successfully
applied
estimation
its
tablets
human
urine
samples
high
%
recoveries
(98.04-101.67)
low
%RSD
(<
1.5)
values.
Furthermore,
content
uniformity
testing
accordance
USP
guidelines.
method's
eco-friendliness
evaluated
AGREE
ComplexGAPI
metrics.
Validation
according
to
ICHQ2
(R2)
Язык: Английский
Greenness, blueness, and whiteness evaluation of a density functional theory-validated photoinduced electron transfer deactivation protocol for sensitive fluorescence determination of butenafine
Microchemical Journal,
Год журнала:
2025,
Номер
unknown, С. 113639 - 113639
Опубликована: Апрель 1, 2025
Язык: Английский
Ultrasensitive First Derivative Synchronous Spectrofluorimetric Approach for the Concurrent Quantification of COVID‐19‐2024 Treatment Combination Dextromethorphan and Guaifenesin in Different Matrices: Compliance With Greenness and Practicality Metrics
Luminescence,
Год журнала:
2025,
Номер
40(4)
Опубликована: Апрель 1, 2025
ABSTRACT
The
COVI
D‐19‐2024
is
one
of
the
most
frequently
occurring
illnesses
worldwide.
One
symptoms
COVID‐19
sever
cough.
This
study
presents
a
novel
first
derivative
synchronous
spectrofluorimetric
method
that
rapid,
highly
sensitive,
cost‐effective,
and
environmentally
safe
for
determining
two
coformulated
anticough
drugs,
dextromethorphan
guaifenesin,
simultaneously.
At
281.5
297.4
nm,
respectively,
fluorescence
guaifenesin
was
measured.
dilution
solvent
methanol,
wavelength
difference
(Δλ)
20
nm.
verified
good
linearity
(
r
>
0.999)
both
(10.0–200.0
ng
mL
−1
)
(30.0–800.0
within
intended
concentration
ranges.
findings
showed
suggested
had
high
degree
sensitivity,
with
detection
limits
being
8.64
1.81
,
respectively.
For
analytes,
intraday
interday
precisions
were
less
than
0.81%
RSD.
With
low
percentage
RSD
values
recoveries,
developed
successfully
used
to
estimate
aforementioned
medications
in
dosage
forms
human
plasma
samples
CACI
tool
evaluated
method's
economy,
usefulness,
applicability,
whereas
MoGAPI
AGREE
metrics
its
exceptional
eco‐friendliness
greenness.
procedure
thoroughly
compliance
ICH
Q2
(R2)
standards.
Язык: Английский
A novel ultrasensitive derivatization-free synchronous fluorescence approach for the simultaneous analysis of propofol and nalbuphine in human plasma and dosage forms: Compliance with greenness and blueness metrics
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Год журнала:
2025,
Номер
340, С. 126339 - 126339
Опубликована: Май 5, 2025
Язык: Английский