TS-AI: A deep learning pipeline for multimodal subject-specific parcellation with task contrasts synthesis DOI Open Access
Chengyi Li, Yuheng Lu,

Yu Shan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Abstract Accurate mapping of brain functional subregions at an individual level is crucial. Task-based MRI (tfMRI) captures subject-specific activation patterns during various functions and behaviors, facilitating the localization functionally distinct subregions. However, acquiring high-quality tfMRI time-consuming resource-intensive in both scientific clinical settings. The present study proposes a two-stage network model, TS-AI, to individualize atlas on cortical surfaces through prediction data. TS-AI first synthesizes battery task contrast maps for each by leveraging tract-wise anatomical connectivity resting-state networks. These synthesized maps, along with feature networks, are then fed into end-to-end deep neural atlas. enables be used parcellation without acquisition actual fMRI scans. In addition, novel consistency loss designed assign vertices similar features same parcel, which increases specificity mitigates overfitting risks caused absence ground truth. individualized parcellations were validated assessing test-retest reliability, homogeneity, cognitive behavior using diverse reference atlases datasets, demonstrating superior performance generalizability TS-AI. Sensitivity analysis yielded insights region-specific influencing variation regionalization. identified accelerated shrinkage medial temporal cingulate parcels progression Alzheimer’s disease, suggesting its potential research applications.

Language: Английский

Multimodal Connectivity-Based Individual Parcellation and Analysis for Humans and Rhesus Monkeys DOI
Yue Cui, Chengyi Li, Yuheng Lu

et al.

IEEE Transactions on Medical Imaging, Journal Year: 2024, Volume and Issue: 43(9), P. 3343 - 3353

Published: April 24, 2024

Individual brains vary greatly in morphology, connectivity and organization. Individualized brain parcellation is capable of precisely localizing subject-specific functional regions. However, most individualization approaches have examined single modalities data not generalized to nonhuman primates. The present study proposed a novel multimodal connectivity-based individual (MCIP) method, which optimizes within-region homogeneity, spatial continuity similarity reference atlas with the fusion personal anatomical connectivity. Comprehensive evaluation demonstrated that MCIP outperformed state-of-the-art methods terms predictability cognitive measures, heritability, reproducibility generalizability across species. Comparative investigation showed higher topographic variability humans than macaques. Therefore, provides improved accurate reliable mapping regions over existing at an level species, could facilitate comparative translational neuroscience research.

Language: Английский

Citations

4
The Chimpanzee Brainnetome Atlas reveals distinct connectivity and gene expression profiles relative to humans DOI Creative Commons
Yufan Wang, Luqi Cheng, Deying Li

et al.

The Innovation, Journal Year: 2025, Volume and Issue: 6(2), P. 100755 - 100755

Published: Jan. 6, 2025

Chimpanzees (Pan troglodytes) are one of humans' closest living relatives, making them the most directly relevant comparison point for understanding human brain evolution. Zeroing in on differences connectivity between humans and chimpanzees can provide key insights into specific evolutionary changes that might have occurred along lineage. However, such comparisons hindered by absence cross-species atlases established within same framework. To address this gap, we developed Chimpanzee Brainnetome Atlas (ChimpBNA) using a connectivity-based parcellation Leveraging new resource, found substantial divergence patterns two species across association cortices, notably lateral temporal dorsolateral prefrontal cortex. These deviate sharply from pattern cortical expansion observed when comparing to chimpanzees, highlighting more complex nuanced evolution than previously recognized. Additionally, identified regions displaying connectional asymmetries differed species, likely resulting divergence. Genes highly expressed divergent connectivities were enriched cell types crucial projection circuits synapse formation, whose pronounced expression hint at genetic influences neural circuit development, function, Our study provides fine-scale chimpanzee atlas highlights chimpanzee-human rigorous comparative manner. In addition, these results suggest potential gene correlates species-specific linking neuroimaging data, offering human-unique cognitive capabilities.

Language: Английский

Citations

0
基于多尺度特征网络的高动态范围图像压缩 DOI

刘亚搏 Liu Yabo,

杨孝全 Yang Xiaoquan,

江涛 Jiang Tao

et al.

Laser & Optoelectronics Progress, Journal Year: 2025, Volume and Issue: 62(4), P. 0437007 - 0437007

Published: Jan. 1, 2025

Citations

0
Integrating multimodal data to understand cortical circuit architecture and function DOI
Anton Arkhipov, Nuno Maçarico da Costa, Saskia de Vries

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Citations

0
Evolution of the Rich Club Properties in Mouse, Macaque, and Human Brain Networks: A Study of Functional Integration, Segregation, and Balance DOI
Xiaoru Zhang, Ming Song, Wentao Jiang

et al.

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Language: Английский

Citations

0
Arcuate Fasciculus: Evolutionary Convergence in Marmosets and Humans DOI Creative Commons
Yufan Wang, Luqi Cheng, Deying Li

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract The marmoset is a highly vocal platyrrhine monkey that shares key anatomical and functional features with humans, providing unique opportunity to illuminate the phylogenetic origins of diverging connectivity profiles their transformations throughout evolution. Although similarity vocalization between humans has been reported, whether marmosets possess an arcuate fasciculus homolog not known. In this study, we delineated white matter tracts in marmosets, establishing homologies those observed other primates, including macaques, chimpanzees, humans. presence was confirmed by tracer ultra-high-resolution diffusion magnetic resonance imaging datasets. Using blueprint approach, compared cortical patterns across these species found terminates ventral frontal cortex, exceeds something corroborated quantitative analyses after transforming all brains into common space. To explore fasciculus’ support for species-specific vocalizations, activation communications were associated connectivity. Collectively, our findings suggest dorsal pathway, which emerged early evolution, evolved convergently despite distant kindship.

Language: Английский

Citations

0
TS-AI: A deep learning pipeline for multimodal subject-specific parcellation with task contrasts synthesis DOI
Chengyi Li, Yuheng Lu, Shan Yu

et al.

Medical Image Analysis, Journal Year: 2024, Volume and Issue: 97, P. 103297 - 103297

Published: Aug. 8, 2024

Language: Английский

Citations

1
Mapping sagittal-plane reference brain atlas of the cynomolgus macaque (Macaca fascicularis) based on consecutive cytoarchitectonic images DOI Creative Commons
Yue Luo, Xiangning Li, Can Zhou

et al.

Brain Structure and Function, Journal Year: 2024, Volume and Issue: 229(8), P. 2045 - 2057

Published: Aug. 27, 2024

The brain atlas is essential for exploring the anatomical structure and function of brain. Non-human primates, such as cynomolgus macaque, have received increasing attention due to their genetic similarity humans. However, current macaque atlases only offer coarse sections with intervals along coronal direction, failing meet needs single-cell resolution studies in functional multi-omics research To address this issue, we utilized fluorescence micro-optical sectioning tomography obtain sub-micron cytoarchitectonic images at sagittal plane. Based on obtained 8000 image sequences, a reference comprising 45 was created, delineating 270 regions other than cortex. Additionally, website established share corresponding data. This study expected provide an dataset tool scientists studying

Language: Английский

Citations

1
Comparative Analysis of Human-Chimpanzee Divergence in Brain Connectivity and its Genetic Underpinnings DOI Creative Commons
Yufan Wang, Luqi Cheng, Deying Li

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Chimpanzees (

Language: Английский

Citations

0
TS-AI: A deep learning pipeline for multimodal subject-specific parcellation with task contrasts synthesis DOI Open Access
Chengyi Li, Yuheng Lu,

Yu Shan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Abstract Accurate mapping of brain functional subregions at an individual level is crucial. Task-based MRI (tfMRI) captures subject-specific activation patterns during various functions and behaviors, facilitating the localization functionally distinct subregions. However, acquiring high-quality tfMRI time-consuming resource-intensive in both scientific clinical settings. The present study proposes a two-stage network model, TS-AI, to individualize atlas on cortical surfaces through prediction data. TS-AI first synthesizes battery task contrast maps for each by leveraging tract-wise anatomical connectivity resting-state networks. These synthesized maps, along with feature networks, are then fed into end-to-end deep neural atlas. enables be used parcellation without acquisition actual fMRI scans. In addition, novel consistency loss designed assign vertices similar features same parcel, which increases specificity mitigates overfitting risks caused absence ground truth. individualized parcellations were validated assessing test-retest reliability, homogeneity, cognitive behavior using diverse reference atlases datasets, demonstrating superior performance generalizability TS-AI. Sensitivity analysis yielded insights region-specific influencing variation regionalization. identified accelerated shrinkage medial temporal cingulate parcels progression Alzheimer’s disease, suggesting its potential research applications.

Language: Английский

Citations

0