Toxicology Research,
Год журнала:
2019,
Номер
8(5), С. 630 - 640
Опубликована: Июнь 2, 2019
Bisphenol
A
(BPA)
is
a
typical
endocrine
disruptor.
S
(BPS)
has
been
widely
used
as
substitute
for
various
plastic
materials
due
to
the
limited
application
of
BPA.
However,
it
does
not
mean
that
BPS
safe
lack
effective
evaluation
BPS.
In
this
study,
clinical
model
Caenorhabditis
elegans
(C.
elegans)
was
study
effects
on
locomotion
behavior,
growth,
reproduction,
lifespan
and
antioxidant
system.
Our
found
C.
exposed
0.01
μM
could
have
significantly
inhibited
behavior
well
damaged
reproductive
systems
lifespan.
It
interesting
note
in
multi-generational
exposure
studies,
we
exhibits
complex
genotoxicity.
With
transmission
offspring,
showed
more
significant
inhibition
head
thrashes
nematode,
while
effect
body
bends
length
gradually
weakened.
The
brood
size
shows
different
rules
according
concentrations
offsprings.
Therefore,
safety
still
needs
further
evaluation,
especially
Environmental Science & Technology,
Год журнала:
2017,
Номер
52(2), С. 831 - 838
Опубликована: Дек. 20, 2017
Bisphenol
S
(BPS),
a
structural
analogue
of
bisphenol
A
(BPA),
has
been
increasingly
used
as
common
replacement
BPA
due
to
health
concerns
regarding
the
former.
However,
mounting
evidence
suggests
that
BPS
similar
endocrine-disrupting
effects
BPA,
and
likewise,
its
presence
in
environment
may
pose
considerable
risks
ecosystems
human
health.
Using
fish
primary
macrophages
(fpMQs),
we
here
evaluated
immunomodulatory
mechanisms
action
associated
with
estrogen
receptors
(ERs).
Following
exposure
at
environmentally
relevant
concentrations
from
0.1
1000
μg/L,
observed
approximate
concentration-dependent
increases
nitric
oxide
reactive
oxygen
species
generation
total
antioxidant
capacity
well
gene
expression
inflammatory
cytokines
fpMQs.
impaired
phagocytic
capability
but
enhanced
fpMQ
activation
levels
response
lipopolysaccharide
stimulation
promoted
apoptosis,
indicating
an
impact
on
cell
functions.
At
concentration
100
showed
comparable
pro-inflammatory
potential
both
up-regulating
production
free
radicals
cytokine
expression;
however,
had
no
significant
potency
regards
inducing
lipid
peroxidation
different
BPA's
effects.
Moreover,
induced
erα
erβ2
fpMQs,
whereas
only
expression.
This
study
demonstrates
that,
similarly
low
doses
significantly
disturbs
immune
fpMQs
vitro
first
reveals
overlapping
roles
ERs
BPA.
PLoS ONE,
Год журнала:
2018,
Номер
13(2), С. e0193387 - e0193387
Опубликована: Фев. 21, 2018
Bisphenol
S
(BPS)
is
an
industrial
alternative
to
the
endocrine
disruptor
bisphenol
A
(BPA),
and
can
be
found
in
many
products
labeled
"BPA-free".
Its
use
has
grown
recent
years,
presently
it
considered
a
ubiquitous
emerging
pollutant.
To
date
there
lack
of
information
on
effects
BPS
invertebrates,
although
they
represent
more
than
95%
known
species
animal
kingdom
are
crucial
for
structure
proper
function
ecosystems.
In
this
study,
real-time
RT-PCR
was
used
determine
early
detrimental
transcriptional
rate
genes
model
Chironomus
riparius,
specifically
those
related
ecdysone
pathway
(EcR,
ERR,
E74,
Vtg,
cyp18a1)
insect
development
metamorphosis,
stress
biotransformation
mechanisms
(hsp70,
hsp40,
cyp4g,
GPx,
GSTd3)
that
regulate
adaptive
responses
survival,
ribosome
biogenesis
(its2,
rpL4,
rpL13)
which
essential
protein
synthesis
homeostasis.
While
24-hour
exposure
0.5,
5,
50,
500
μg/L
had
no
effect
larval
almost
all
studied
were
upregulated
following
non-monotonic
dose-response
curve.
Genes
with
greatest
increases
activity
(fold
change
relative
control)
EcR
(3.8),
ERR
(2),
E74
(2.4),
cyp18a1
(2.5),
hsp70
(1.7),
hsp40
cyp4g
(6.4),
GPx
(1.8),
GST
(2.1),
while
others
including
GAPDH,
selected
ribosomal
remained
stable.
We
also
measured
these
24
hours
after
withdrawal
general
downregulation
compared
controls
observed,
though
not
significant
most
cases.
Our
findings
showed
altered
profile
genes,
may
have
consequences
hormone
system
several
metabolic
pathways.
Although
further
research
needed
elucidate
its
mode
action,
results
raise
new
concerns
about
safety
BPA
alternatives.
Toxicology Research,
Год журнала:
2019,
Номер
8(5), С. 630 - 640
Опубликована: Июнь 2, 2019
Bisphenol
A
(BPA)
is
a
typical
endocrine
disruptor.
S
(BPS)
has
been
widely
used
as
substitute
for
various
plastic
materials
due
to
the
limited
application
of
BPA.
However,
it
does
not
mean
that
BPS
safe
lack
effective
evaluation
BPS.
In
this
study,
clinical
model
Caenorhabditis
elegans
(C.
elegans)
was
study
effects
on
locomotion
behavior,
growth,
reproduction,
lifespan
and
antioxidant
system.
Our
found
C.
exposed
0.01
μM
could
have
significantly
inhibited
behavior
well
damaged
reproductive
systems
lifespan.
It
interesting
note
in
multi-generational
exposure
studies,
we
exhibits
complex
genotoxicity.
With
transmission
offspring,
showed
more
significant
inhibition
head
thrashes
nematode,
while
effect
body
bends
length
gradually
weakened.
The
brood
size
shows
different
rules
according
concentrations
offsprings.
Therefore,
safety
still
needs
further
evaluation,
especially
