Antibiotic resistance in the environment

Nature Reviews Microbiology, Год журнала: 2021, Номер 20(5), С. 257 - 269

Опубликована: Ноя. 4, 2021

Язык: Английский

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Environmental factors influencing the development and spread of antibiotic resistance

FEMS Microbiology Reviews, Год журнала: 2017, Номер 42(1)

Опубликована: Окт. 19, 2017

Antibiotic resistance and its wider implications present us with a growing healthcare crisis. Recent research points to the environment as an important component for transmission of resistant bacteria in emergence pathogens. However, deeper understanding evolutionary ecological processes that lead clinical appearance genes is still lacking, knowledge environmental dispersal barriers. This calls better models how evolve, are mobilized, transferred disseminated environment. Here, we attempt define factors contribute development transmission. Although mobilization likely occurs continuously, great majority such genetic events do not establishment novel bacterial populations, unless there selection pressure maintaining them or their fitness costs negligible. To enable preventative measures it therefore critical investigate under what conditions extent takes place. In addition, barriers only key evaluate risks, but also prevent pathogens, well genes, from reaching humans.

Язык: Английский

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Defining and combating antibiotic resistance from One Health and Global Health perspectives

Nature Microbiology, Год журнала: 2019, Номер 4(9), С. 1432 - 1442

Опубликована: Авг. 22, 2019

Язык: Английский

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Antibiotics and antibiotic resistant genes (ARGs) in groundwater: A global review on dissemination, sources, interactions, environmental and human health risks

Water Research, Год журнала: 2020, Номер 187, С. 116455 - 116455

Опубликована: Сен. 28, 2020

Язык: Английский

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Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments: Current knowledge and questions to be answered

Critical Reviews in Environmental Science and Technology, Год журнала: 2019, Номер 50(19), С. 2016 - 2059

Опубликована: Дек. 3, 2019

Aquatic environments are identified as an ideal setting for acquisition and dissemination of antibiotic resistance, human exposure to resistant bacteria (ARB) resistance genes (ARGs) in aquatic may pose additional health risk. Quantitative microbial risk assessment (QMRA) has been suggested a suitable method evaluate quantify this However, information about the ARB ARGs is lacking many scenarios dose-response models regarding infections not developed yet. This review summarizes current knowledge highlights challenging questions remaining be answered better forecast risks caused by water environments. The include what missing needed exposing environments? markers ARB/ARGs contamination how frequently do ARG selection propagation occur there any unknown hot spots? Studies on above topics will contribute management its health.Abbreviations3GC3rd generation cephalosporinsARBAntibiotic bacteriaARGAntibiotic geneCFUColony forming unitDBPDisinfection by-productseDNAExtracellular DNAEPSExtracellular polymeric substancesHGTHorizontal gene transferISCRInsertion sequence common regionMARMultiple resistantMICMinimum inhibitory concentrationMGEMobile genetic elementsMSWMunicipal solid wasteQMRAQuantitative assessmentVBNCViable but non-culturableWWTPWastewater treatment plant

Язык: Английский

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Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution

Drug Resistance Updates, Год журнала: 2019, Номер 44, С. 100640 - 100640

Опубликована: Май 1, 2019

Язык: Английский

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Antibiotic resistance in wastewater treatment plants: Tackling the black box

Environment International, Год журнала: 2018, Номер 115, С. 312 - 324

Опубликована: Апрель 6, 2018

Язык: Английский

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Environmental antimicrobial resistance and its drivers: a potential threat to public health

Journal of Global Antimicrobial Resistance, Год журнала: 2021, Номер 27, С. 101 - 111

Опубликована: Авг. 25, 2021

Imprudent and overuse of clinically relevant antibiotics in agriculture, veterinary medical sectors contribute to the global epidemic increase antimicrobial resistance (AMR). There is a growing concern among researchers stakeholders that environment acts as an AMR reservoir plays key role dissemination genes (ARGs). Various drivers are contributing factors spread antibiotic-resistant bacteria their ARGs either directly through drug use health care, agriculture/livestock or antibiotic residues released from various domestic settings. Resistant micro-organisms enter soil, air, water sediments routes hotspots such hospital wastewater, agricultural waste wastewater treatment plants. Global mitigation strategies primarily involve identification high-risk environments responsible for evolution resistance. Subsequently, transmission affected by standards infection control, sanitation, access clean water, assured quality antimicrobials diagnostics, travel migration. This review provides brief description possible contribution different environmental mechanisms. We also aim highlight knowledge gaps hinder regulators delivering protection against AMR.

Язык: Английский

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Antibiotic Resistance: One Health One World Outlook

Frontiers in Cellular and Infection Microbiology, Год журнала: 2021, Номер 11

Опубликована: Ноя. 25, 2021

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it now regarded as critical One Health issue. Health's interconnected domains contribute to the emergence, evolution, spread of antibiotic-resistant microorganisms on local global scale, which significant risk factor for health. The persistence resistant microbial species, association determinants at human-animal-environment interface can alter genomes, resulting in superbugs various niches. ABR motivated by well-established link between three domains: human, animal, environmental As result, addressing through approach makes sense. Several countries have implemented national action plans based combat microbes, following Tripartite's Commitment Food Agriculture Organization (FAO)-World Animal (OIE)-World (WHO) guidelines. has been identified concern, efforts are being made mitigate this threat. To summarize, interdisciplinary unified approaches principles required limit dissemination cycle, raise awareness education about antibiotic use, promote policy, advocacy, antimicrobial stewardship.

Язык: Английский

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How Antimicrobial Resistance Is Linked to Climate Change: An Overview of Two Intertwined Global Challenges

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(3), С. 1681 - 1681

Опубликована: Янв. 17, 2023

Globally, antimicrobial resistance (AMR) and climate change (CC) are two of the top health emergencies, can be considered as interlinked public priorities. The complex commonalities between AMR CC should deeply investigated in a One Health perspective. Here, we provided an overview current knowledge about relationship CC. Overall, studies included pointed out need for applying systemic approach to planetary health. Firstly, increasingly brings humans animals into contact, leading outbreaks zoonotic vector-borne diseases with pandemic potential. Although it is well-established that use human, animal environmental sectors one main drivers AMR, COVID-19 exacerbating scenario, by influencing antibiotics, personal protective equipment, biocides. This also results higher concentrations contaminants (e.g., microplastics) natural water bodies, which cannot completely removed from wastewater treatment plants, could sustain spread. Our underlined lack on direct CC, encouraged further research investigate multiple aspects involved, its effect human

Язык: Английский

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