Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2022,
Номер
377(1861)
Опубликована: Авг. 22, 2022
Horizontal
gene
transfer
(HGT)
drives
microbial
adaptation
but
is
often
under
the
control
of
mobile
genetic
elements
(MGEs)
whose
interests
are
not
necessarily
aligned
with
those
their
hosts.
In
general,
costly
to
donor
cell
while
potentially
beneficial
recipients.
The
diversity
and
plasticity
cell-MGEs
interactions,
among
MGEs,
result
in
complex
evolutionary
processes
where
source,
or
even
existence
selection
for
maintaining
a
function
genome,
unclear.
For
example,
MGE-driven
HGT
depends
on
envelope
structures
defense
systems,
many
these
transferred
by
MGEs
themselves.
can
spur
periods
intense
increasing
own
rates
horizontal
transmission
upon
communicating,
eavesdropping,
sensing
environment
host
physiology.
This
may
high-frequency
genes
unrelated
MGE.
Here,
we
review
how
drive
mechanisms,
selective
pressures
genomic
traits
affect
flow,
therefore
adaptation,
populations.
encoding
adaptive
niche-defining
means
that
intragenomic
conflicts
alliances
between
cells
key
functional
diversification.
article
part
discussion
meeting
issue
'Genomic
population
pathogens'.
FEMS Microbiology Reviews,
Год журнала:
2017,
Номер
42(1)
Опубликована: Окт. 19, 2017
Antibiotic
resistance
and
its
wider
implications
present
us
with
a
growing
healthcare
crisis.
Recent
research
points
to
the
environment
as
an
important
component
for
transmission
of
resistant
bacteria
in
emergence
pathogens.
However,
deeper
understanding
evolutionary
ecological
processes
that
lead
clinical
appearance
genes
is
still
lacking,
knowledge
environmental
dispersal
barriers.
This
calls
better
models
how
evolve,
are
mobilized,
transferred
disseminated
environment.
Here,
we
attempt
define
factors
contribute
development
transmission.
Although
mobilization
likely
occurs
continuously,
great
majority
such
genetic
events
do
not
establishment
novel
bacterial
populations,
unless
there
selection
pressure
maintaining
them
or
their
fitness
costs
negligible.
To
enable
preventative
measures
it
therefore
critical
investigate
under
what
conditions
extent
takes
place.
In
addition,
barriers
only
key
evaluate
risks,
but
also
prevent
pathogens,
well
genes,
from
reaching
humans.
Critical Reviews in Environmental Science and Technology,
Год журнала:
2019,
Номер
50(19), С. 2016 - 2059
Опубликована: Дек. 3, 2019
Aquatic
environments
are
identified
as
an
ideal
setting
for
acquisition
and
dissemination
of
antibiotic
resistance,
human
exposure
to
resistant
bacteria
(ARB)
resistance
genes
(ARGs)
in
aquatic
may
pose
additional
health
risk.
Quantitative
microbial
risk
assessment
(QMRA)
has
been
suggested
a
suitable
method
evaluate
quantify
this
However,
information
about
the
ARB
ARGs
is
lacking
many
scenarios
dose-response
models
regarding
infections
not
developed
yet.
This
review
summarizes
current
knowledge
highlights
challenging
questions
remaining
be
answered
better
forecast
risks
caused
by
water
environments.
The
include
what
missing
needed
exposing
environments?
markers
ARB/ARGs
contamination
how
frequently
do
ARG
selection
propagation
occur
there
any
unknown
hot
spots?
Studies
on
above
topics
will
contribute
management
its
health.Abbreviations3GC3rd
generation
cephalosporinsARBAntibiotic
bacteriaARGAntibiotic
geneCFUColony
forming
unitDBPDisinfection
by-productseDNAExtracellular
DNAEPSExtracellular
polymeric
substancesHGTHorizontal
gene
transferISCRInsertion
sequence
common
regionMARMultiple
resistantMICMinimum
inhibitory
concentrationMGEMobile
genetic
elementsMSWMunicipal
solid
wasteQMRAQuantitative
assessmentVBNCViable
but
non-culturableWWTPWastewater
treatment
plant
Journal of Global Antimicrobial Resistance,
Год журнала:
2021,
Номер
27, С. 101 - 111
Опубликована: Авг. 25, 2021
Imprudent
and
overuse
of
clinically
relevant
antibiotics
in
agriculture,
veterinary
medical
sectors
contribute
to
the
global
epidemic
increase
antimicrobial
resistance
(AMR).
There
is
a
growing
concern
among
researchers
stakeholders
that
environment
acts
as
an
AMR
reservoir
plays
key
role
dissemination
genes
(ARGs).
Various
drivers
are
contributing
factors
spread
antibiotic-resistant
bacteria
their
ARGs
either
directly
through
drug
use
health
care,
agriculture/livestock
or
antibiotic
residues
released
from
various
domestic
settings.
Resistant
micro-organisms
enter
soil,
air,
water
sediments
routes
hotspots
such
hospital
wastewater,
agricultural
waste
wastewater
treatment
plants.
Global
mitigation
strategies
primarily
involve
identification
high-risk
environments
responsible
for
evolution
resistance.
Subsequently,
transmission
affected
by
standards
infection
control,
sanitation,
access
clean
water,
assured
quality
antimicrobials
diagnostics,
travel
migration.
This
review
provides
brief
description
possible
contribution
different
environmental
mechanisms.
We
also
aim
highlight
knowledge
gaps
hinder
regulators
delivering
protection
against
AMR.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2021,
Номер
11
Опубликована: Ноя. 25, 2021
Antibiotic
resistance
(ABR)
is
a
growing
public
health
concern
worldwide,
and
it
now
regarded
as
critical
One
Health
issue.
Health's
interconnected
domains
contribute
to
the
emergence,
evolution,
spread
of
antibiotic-resistant
microorganisms
on
local
global
scale,
which
significant
risk
factor
for
health.
The
persistence
resistant
microbial
species,
association
determinants
at
human-animal-environment
interface
can
alter
genomes,
resulting
in
superbugs
various
niches.
ABR
motivated
by
well-established
link
between
three
domains:
human,
animal,
environmental
As
result,
addressing
through
approach
makes
sense.
Several
countries
have
implemented
national
action
plans
based
combat
microbes,
following
Tripartite's
Commitment
Food
Agriculture
Organization
(FAO)-World
Animal
(OIE)-World
(WHO)
guidelines.
has
been
identified
concern,
efforts
are
being
made
mitigate
this
threat.
To
summarize,
interdisciplinary
unified
approaches
principles
required
limit
dissemination
cycle,
raise
awareness
education
about
antibiotic
use,
promote
policy,
advocacy,
antimicrobial
stewardship.
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(3), С. 1681 - 1681
Опубликована: Янв. 17, 2023
Globally,
antimicrobial
resistance
(AMR)
and
climate
change
(CC)
are
two
of
the
top
health
emergencies,
can
be
considered
as
interlinked
public
priorities.
The
complex
commonalities
between
AMR
CC
should
deeply
investigated
in
a
One
Health
perspective.
Here,
we
provided
an
overview
current
knowledge
about
relationship
CC.
Overall,
studies
included
pointed
out
need
for
applying
systemic
approach
to
planetary
health.
Firstly,
increasingly
brings
humans
animals
into
contact,
leading
outbreaks
zoonotic
vector-borne
diseases
with
pandemic
potential.
Although
it
is
well-established
that
use
human,
animal
environmental
sectors
one
main
drivers
AMR,
COVID-19
exacerbating
scenario,
by
influencing
antibiotics,
personal
protective
equipment,
biocides.
This
also
results
higher
concentrations
contaminants
(e.g.,
microplastics)
natural
water
bodies,
which
cannot
completely
removed
from
wastewater
treatment
plants,
could
sustain
spread.
Our
underlined
lack
on
direct
CC,
encouraged
further
research
investigate
multiple
aspects
involved,
its
effect
human
