International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(2), С. 638 - 638
Опубликована: Янв. 6, 2022
Deltamethrin
(DLM)
is
a
synthetic
pyrethroid
with
anti-acaricide
and
insecticidal
properties.
It
commonly
used
in
agriculture
veterinary
medicine.
Humans
animals
are
exposed
to
DLM
through
the
ingestion
of
polluted
food
water,
resulting
severe
health
issues.
N-acetylcysteine
(NAC)
prodrug
L-cysteine,
precursor
glutathione.
can
restore
oxidant-antioxidant
balance.
Therefore,
this
research
aimed
examine
whether
NAC
may
protect
broiler
chickens
against
oxidative
stress,
at
level
biochemical
molecular
alterations
caused
by
intoxication.
The
indicators
liver
kidney
injury
serum
DLM-intoxicated
NAC-treated
groups
were
examined.
Furthermore,
lipid
peroxidation,
antioxidant
markers,
superoxide
dismutase
activity,
apoptotic
gene
expressions
(caspase-3
Bcl-2)
investigated.
All
parameters
significantly
altered
group,
suggesting
that
could
induce
damage
apoptosis
hepato-renal
tissue.
majority
changes
studied
reversed
when
therapy
was
used.
In
conclusion,
virtue
its
antiapoptotic
properties,
enabled
provision
significant
protection
effects
DLM-induced
injury.
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Arsenic
has
been
ranked
as
the
most
hazardous
substance
by
U.S.
Agency
for
Toxic
Substances
and
Disease
Registry.
Environmental
arsenic
exposure-evoked
health
risks
have
become
a
vital
public
concern
worldwide
owing
to
widespread
existence
of
arsenic.
Multi-omics
is
revolutionary
technique
data
analysis
providing
an
integrated
view
bioinformation
comprehensively
systematically
understanding
elaborate
mechanism
diseases.
This
study
aimed
at
uncovering
potential
contribution
liver-microbiota-gut
axis
in
chronic
inorganic
exposure-triggered
biotoxicity
chickens
based
on
multi-omics
technologies.
Forty
Hy-Line
W-80
laying
hens
were
chronically
exposed
sodium
arsenite
with
dose-dependent
manner
(administered
drinking
water
containing
10,
20,
or
30
mg/L
arsenic,
respectively)
42
d,
followed
transcriptomics,
serum
non-targeted
metabolome,
16S
ribosomal
RNA
gene
sequencing
accordingly.
intervention
induced
serious
chicken
liver
dysfunction,
especially
severe
fibrosis,
simultaneously
altered
ileal
microbiota
populations,
impaired
intestinal
barrier,
further
drove
enterogenous
lipopolysaccharides
translocation
via
portal
vein
circulation
aggravating
damage.
Furtherly,
injured
disturbed
bile
acids
(BAs)
homoeostasis
through
strongly
up-regulating
BAs
synthesis
key
rate-limiting
enzyme
CYP7A1,
inducing
excessive
total
accumulation,
accompanied
massive
primary
BA—chenodeoxycholic
acid.
Moreover,
concentrations
secondary
BAs—ursodeoxycholic
acid
lithocholic
markedly
repressed,
which
might
involve
repressed
dehydroxylation
Ruminococcaceae
Lachnospiraceae
families.
Abnormal
metabolism
turn
promoted
injury,
ultimately
perpetuating
pernicious
circle
chickens.
Notably,
obvious
depletion
abundance
four
profitable
microbiota,
Christensenellaceae,
Ruminococcaceae,
Muribaculaceae,
Faecalibacterium,
correlated
tightly
this
hepato-intestinal
process
Our
demonstrates
that
exposure
evokes
disruption
establishes
scientific
basis
evaluating
risk
environmental
pollutant
Imidacloprid
is
a
neonicotinoid
insecticide
that
has
been
widely
used
to
control
insect
pests
in
agricultural
fields
for
decades.
It
shows
insecticidal
activity
mainly
by
blocking
the
normal
conduction
of
central
nervous
system
insects.
However,
recent
years,
imidacloprid
reported
be
an
emerging
contaminant
all
parts
world,
and
different
toxic
effects
on
variety
non-target
organisms,
including
human
beings,
due
its
large-scale
use.
Hence,
removal
from
ecosystem
received
widespread
attention.
Different
remediation
approaches
have
studied
eliminate
residues
environment,
such
as
oxidation,
hydrolysis,
adsorption,
ultrasound,
illumination,
biodegradation.
In
nature,
microbial
degradation
one
most
important
processes
controlling
fate
transformation
use,
environmental
point
view,
it
promising
means,
effective,
least
hazardous,
environmentally
friendly.
To
date,
several
imidacloprid-degrading
microbes,
Bacillus,
Pseudoxanthomonas,
Mycobacterium,
Rhizobium,
Rhodococcus,
Stenotrophomonas,
characterized
addition,
previous
studies
found
many
insects
microorganisms
developed
resistance
genes
enzymes
imidacloprid.
Furthermore,
metabolites
pathways
reported.
reviews
toxicity
mechanisms
are
rare.
this
review,
summarized
order
provide
theoretical
practical
basis
imidacloprid-contaminated
environments.
Ecotoxicology and Environmental Safety,
Год журнала:
2020,
Номер
207, С. 111501 - 111501
Опубликована: Ноя. 3, 2020
Deltamethrin
(DLM)
is
widely
used
in
agriculture
and
the
prevention
of
human
insect-borne
diseases.
However,
molecular
mechanism
DLM
induced
liver
injury
remains
unclear
to
date.
This
study
investigated
potential
that
fibrosis
quails.
Japanese
quails
received
resveratrol
(500
mg/kg)
daily
with
or
without
(45
exposure
for
12
weeks.
Histopathology,
transmission
electron
microscopy,
biochemical
indexes,
TUNEL,
quantitative
real-time
PCR,
western
blot
analysis
were
performed.
hepatic
steatosis,
oxidative
stress,
inflammation,
apoptosis.
Most
importantly,
Nrf2/TGF-β1/Smad3
signaling
pathway
played
an
important
role
on
DLM-induced
Interestingly,
addition
resveratrol,
Nrf2
activator,
alleviates
stress
inflammation
response
by
activating
Nrf2,
thereby
inhibits
Collectively,
these
findings
demonstrate
chronic
induces
via
expression
inhibition
apoptosis,
then
results
activation
NF-κB/TNF-α
TGF-β1/Smad3
pathway.
Journal of Advanced Research,
Год журнала:
2021,
Номер
35, С. 129 - 140
Опубликована: Апрель 8, 2021
Hexavalent
chromium
(Cr(VI)),
one
of
the
toxic
heavy
metals,
poses
a
serious
threat
to
human
and
animal
health.
Protein
acetylation
regulates
structure
function
most
proteins
in
variety
ways.
However,
hepatotoxicity
Cr(VI)
whether
it
is
related
deacetylation
remains
largely
unknown.We
aimed
explore
link
between
silent
information
regulator
two
ortholog
1
(Sirt1)
induced
by
exposure,
better
clarify
biological
mechanism
liver
injury
Cr(VI).We
established
model
K2Cr2O7
injecting
rats
intraperitoneally
for
35
days
continuously
adding
resveratrol
(Res)
further
hepatotoxicity.The
results
revealed
that
inflammatory
response
apoptosis
hepatocytes.
Furthermore,
reduced
Sirt1
expression
inhibited
downstream
key
transcription
factors,
including
nuclear
factor
erythroid
2-related
2
(Nrf2),
Forkhead
box
O3
(FOXO3),
factor-kappa
B
(NF-κB).
Conversely,
when
Res
was
administered
as
an
activator
Sirt1,
enhanced,
were
significantly
alleviated.In
summary,
this
work
firstly
demonstrates
induces
rat
inhibiting
which
positive
significance
protecting
natural
environment
health
from
chronic
Cr
poisoning.
