N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues DOI Open Access

Ali M. Allam,

Ahmed Abdeen, Hari Prasad Devkota

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(2), P. 638 - 638

Published: Jan. 6, 2022

Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It commonly used in agriculture veterinary medicine. Humans animals are exposed to DLM through the ingestion of polluted food water, resulting severe health issues. N-acetylcysteine (NAC) prodrug L-cysteine, precursor glutathione. can restore oxidant-antioxidant balance. Therefore, this research aimed examine whether NAC may protect broiler chickens against oxidative stress, at level biochemical molecular alterations caused by intoxication. The indicators liver kidney injury serum DLM-intoxicated NAC-treated groups were examined. Furthermore, lipid peroxidation, antioxidant markers, superoxide dismutase activity, apoptotic gene expressions (caspase-3 Bcl-2) investigated. All parameters significantly altered group, suggesting that could induce damage apoptosis hepato-renal tissue. majority changes studied reversed when therapy was used. In conclusion, virtue its antiapoptotic properties, enabled provision significant protection effects DLM-induced injury.

Language: Английский

Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes DOI

Zhiruo Miao,

Zhiying Miao,

Shengchen Wang

et al.

Fish & Shellfish Immunology, Journal Year: 2021, Volume and Issue: 120, P. 674 - 685

Published: Dec. 23, 2021

Language: Английский

Citations

117
Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies DOI Creative Commons

Jiayi Li,

Changming Guo,

Yan Liu

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Arsenic has been ranked as the most hazardous substance by U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public concern worldwide owing to widespread existence of arsenic. Multi-omics is revolutionary technique data analysis providing an integrated view bioinformation comprehensively systematically understanding elaborate mechanism diseases. This study aimed at uncovering potential contribution liver-microbiota-gut axis in chronic inorganic exposure-triggered biotoxicity chickens based on multi-omics technologies. Forty Hy-Line W-80 laying hens were chronically exposed sodium arsenite with dose-dependent manner (administered drinking water containing 10, 20, or 30 mg/L arsenic, respectively) 42 d, followed transcriptomics, serum non-targeted metabolome, 16S ribosomal RNA gene sequencing accordingly. intervention induced serious chicken liver dysfunction, especially severe fibrosis, simultaneously altered ileal microbiota populations, impaired intestinal barrier, further drove enterogenous lipopolysaccharides translocation via portal vein circulation aggravating damage. Furtherly, injured disturbed bile acids (BAs) homoeostasis through strongly up-regulating BAs synthesis key rate-limiting enzyme CYP7A1, inducing excessive total accumulation, accompanied massive primary BA—chenodeoxycholic acid. Moreover, concentrations secondary BAs—ursodeoxycholic acid lithocholic markedly repressed, which might involve repressed dehydroxylation Ruminococcaceae Lachnospiraceae families. Abnormal metabolism turn promoted injury, ultimately perpetuating pernicious circle chickens. Notably, obvious depletion abundance four profitable microbiota, Christensenellaceae, Ruminococcaceae, Muribaculaceae, Faecalibacterium, correlated tightly this hepato-intestinal process Our demonstrates that exposure evokes disruption establishes scientific basis evaluating risk environmental pollutant

Language: Английский

Citations

19
Insights into the Toxicity and Degradation Mechanisms of Imidacloprid Via Physicochemical and Microbial Approaches DOI Creative Commons

Shimei Pang,

Ziqiu Lin,

Yuming Zhang

et al.

Toxics, Journal Year: 2020, Volume and Issue: 8(3), P. 65 - 65

Published: Sept. 1, 2020

Imidacloprid is a neonicotinoid insecticide that has been widely used to control insect pests in agricultural fields for decades. It shows insecticidal activity mainly by blocking the normal conduction of central nervous system insects. However, recent years, imidacloprid reported be an emerging contaminant all parts world, and different toxic effects on variety non-target organisms, including human beings, due its large-scale use. Hence, removal from ecosystem received widespread attention. Different remediation approaches have studied eliminate residues environment, such as oxidation, hydrolysis, adsorption, ultrasound, illumination, biodegradation. In nature, microbial degradation one most important processes controlling fate transformation use, environmental point view, it promising means, effective, least hazardous, environmentally friendly. To date, several imidacloprid-degrading microbes, Bacillus, Pseudoxanthomonas, Mycobacterium, Rhizobium, Rhodococcus, Stenotrophomonas, characterized addition, previous studies found many insects microorganisms developed resistance genes enzymes imidacloprid. Furthermore, metabolites pathways reported. reviews toxicity mechanisms are rare. this review, summarized order provide theoretical practical basis imidacloprid-contaminated environments.

Language: Английский

Citations

93
Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3β/Fyn pathway DOI

Yueying Lv,

Huijie Jiang, Siyu Li

et al.

Environmental Pollution, Journal Year: 2019, Volume and Issue: 259, P. 113812 - 113812

Published: Dec. 18, 2019

Language: Английский

Citations

89
Toxicological effects of deltamethrin on quail cerebrum: Weakened antioxidant defense and enhanced apoptosis DOI
Jiayi Li, Huijie Jiang, Pengfei Wu

et al.

Environmental Pollution, Journal Year: 2021, Volume and Issue: 286, P. 117319 - 117319

Published: May 6, 2021

Language: Английский

Citations

86
Exploring the liver fibrosis induced by deltamethrin exposure in quails and elucidating the protective mechanism of resveratrol DOI Creative Commons
Siyu Li, Xiaoyan Zheng, Xiaoya Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 207, P. 111501 - 111501

Published: Nov. 3, 2020

Deltamethrin (DLM) is widely used in agriculture and the prevention of human insect-borne diseases. However, molecular mechanism DLM induced liver injury remains unclear to date. This study investigated potential that fibrosis quails. Japanese quails received resveratrol (500 mg/kg) daily with or without (45 exposure for 12 weeks. Histopathology, transmission electron microscopy, biochemical indexes, TUNEL, quantitative real-time PCR, western blot analysis were performed. hepatic steatosis, oxidative stress, inflammation, apoptosis. Most importantly, Nrf2/TGF-β1/Smad3 signaling pathway played an important role on DLM-induced Interestingly, addition resveratrol, Nrf2 activator, alleviates stress inflammation response by activating Nrf2, thereby inhibits Collectively, these findings demonstrate chronic induces via expression inhibition apoptosis, then results activation NF-κB/TNF-α TGF-β1/Smad3 pathway.

Language: Английский

Citations

81
Hexavalent chromium induced heart dysfunction via Sesn2-mediated impairment of mitochondrial function and energy supply DOI

Daqian Yang,

Qingyue Yang,

Ning Fu

et al.

Chemosphere, Journal Year: 2020, Volume and Issue: 264, P. 128547 - 128547

Published: Oct. 7, 2020

Language: Английский

Citations

80
Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1α signaling pathway DOI
Qingyue Yang, Bing Han,

Jiangdong Xue

et al.

Environmental Pollution, Journal Year: 2020, Volume and Issue: 265, P. 114855 - 114855

Published: May 23, 2020

Language: Английский

Citations

79
The link between deacetylation and hepatotoxicity induced by exposure to hexavalent chromium DOI Creative Commons
Qingyue Yang, Bing Han, Siyu Li

et al.

Journal of Advanced Research, Journal Year: 2021, Volume and Issue: 35, P. 129 - 140

Published: April 8, 2021

Hexavalent chromium (Cr(VI)), one of the toxic heavy metals, poses a serious threat to human and animal health. Protein acetylation regulates structure function most proteins in variety ways. However, hepatotoxicity Cr(VI) whether it is related deacetylation remains largely unknown.We aimed explore link between silent information regulator two ortholog 1 (Sirt1) induced by exposure, better clarify biological mechanism liver injury Cr(VI).We established model K2Cr2O7 injecting rats intraperitoneally for 35 days continuously adding resveratrol (Res) further hepatotoxicity.The results revealed that inflammatory response apoptosis hepatocytes. Furthermore, reduced Sirt1 expression inhibited downstream key transcription factors, including nuclear factor erythroid 2-related 2 (Nrf2), Forkhead box O3 (FOXO3), factor-kappa B (NF-κB). Conversely, when Res was administered as an activator Sirt1, enhanced, were significantly alleviated.In summary, this work firstly demonstrates induces rat inhibiting which positive significance protecting natural environment health from chronic Cr poisoning.

Language: Английский

Citations

77
Hexavalent chromium induces renal apoptosis and autophagy via disordering the balance of mitochondrial dynamics in rats DOI
Xiaoyan Zheng, Siyu Li, Jiayi Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 204, P. 111061 - 111061

Published: Aug. 1, 2020

Language: Английский

Citations

75