Rapid Communications in Mass Spectrometry,
Год журнала:
2024,
Номер
38(5)
Опубликована: Янв. 15, 2024
Rationale
Personal
care
product
chemicals
(PCPCs)
are
the
used
in
personal
products.
Many
of
them
endocrine
disruptors
and
have
potential
adverse
effects
on
humans.
The
concentrations
PCPCs
urine
main
biomarker
for
assessing
human
exposure.
Methods
A
method
was
developed
simultaneous
determination
14
using
dispersive
liquid–liquid
extraction
combined
with
ultra
high‐performance
liquid
chromatography–tandem
mass
spectrometry
(UHPLC–MS/MS).
Results
Compared
extraction,
this
had
advantages
time
efficiency,
sensitivity,
limited
organic
solvent
consumption.
It
produced
good
linearity
(0.9965–0.9996),
limits
detection
(2.82–36.36
pg
mL
−1
),
quantitation
(9.39–121.08
matrix
effect
(−0.90%–2.55%),
intra‐day
precision
(relative
standard
deviations
[RSDs]
<15%),
inter‐day
(RSDs
<19.9%).
satisfactory
relative
recovery
at
three
concentration
levels.
Conclusions
rapid
quantification
urine.
practicability
verified
21
from
university
students.
is
expected
that
will
provide
a
powerful
reference
assessment
exposure
to
large
populations.
Environmental Science & Technology,
Год журнала:
2021,
Номер
55(8), С. 5117 - 5127
Опубликована: Март 11, 2021
Humans
are
constantly
exposed
to
antimicrobial
triclocarban
(TCC)
via
direct
skin
contact
with
personal
care
and
consumer
products,
but
the
safety
of
long-term
dermal
exposure
TCC
remains
largely
unknown.
Herein,
we
used
a
mouse
model
evaluate
potential
health
risks
from
continuous
application
at
human-relevant
concentrations.
After
percutaneous
absorption,
circulated
in
bloodstream
entered
liver–gut
axis
for
metabolic
disposition.
Nontargeted
metabolomics
approach
revealed
that
perturbed
liver
homeostasis,
as
evidenced
by
increased
oxidative
stress
impaired
methylation
capacity,
leading
damage
enhancement
upstream
glycolysis
folate-dependent
one-carbon
metabolism.
Meanwhile,
was
transformed
through
hydroxylation,
dechlorination,
methylation,
glucuronidation,
sulfation,
glutathione
conjugation.
TCC-derived
xenobiotics
were
subsequently
excreted
into
gut,
glucuronide
sulfate
metabolites
could
be
further
deconjugated
gut
microbiota
their
active
free
forms.
In
addition,
microbial
community
analysis
showed
composition
microbiome
altered
response
exposure,
indicating
perturbation
homeostasis.
Together,
tracking
xenobiotic–biological
interactions
vivo,
this
study
provides
novel
insights
underlying
impacts
dermally
absorbed
on
microenvironments.
Water Biology and Security,
Год журнала:
2022,
Номер
1(4), С. 100063 - 100063
Опубликована: Июль 31, 2022
Triclosan
(TCS)
is
an
endocrine
disrupting
chemical
which
commonly
used
as
a
disinfectant
in
pharmaceuticals
and
personal
care
products
(PPCP's).
Since
early
2020,
the
worldwide
outbreak
of
COVID-19
has
increased
use
PPCP's,
so
occurrence
impact
TCS
on
freshwater
lakes
should
be
considered.
However,
little
attention
been
given
to
effect
China.
This
study
first
attempt
at
risk
assessment
focusing
temporal
spatial
middle
Yangtze
River
basin.
The
surface
water
sediments
Donghu
Lake
Liangzi
(Wuhan,
Central
China)
were
collected
from
October
2020
August
2021.
maximum
concentrations
466
ng/L
239
water,
71
ng/g
25
(dry
weight)
Lake,
respectively.
Significant
differences
observed
within
between
lakes,
with
highest
measured
winter.
Furthermore,
higher
areas
that
are
more
impacted
by
human
activities.
There
was
significant
positive
correlation
nitrogen
water.
A
using
quotient
(RQ)
method
showed
potentially
high
(RQ
>
1)
found
only
waters
posed
lower
than
waters.
These
results
provide
timely
data
China
following
demonstrate
possible
exposure
for
aquatic
biota.
