Probiotic Lactobacillus rhamnosus alleviates the neurotoxicity of microcystin-LR in zebrafish (Danio rerio) through the gut-brain axis

The Science of The Total Environment, Год журнала: 2023, Номер 908, С. 168058 - 168058

Опубликована: Окт. 31, 2023

Язык: Английский

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Microcystin-LR-Exposure-Induced Kidney Damage by Inhibiting MKK6-Mediated Mitophagy in Mice

Toxins, Год журнала: 2023, Номер 15(6), С. 404 - 404

Опубликована: Июнь 19, 2023

Previous studies have reported that microcystin-LR (MC-LR) levels are highly correlated with abnormal renal function indicators, suggesting MC-LR is an independent risk factor for kidney damage. However, the evidence exact regulation mechanism of on damage still limited, and further in-depth exploration needed. In addition, mitochondria-related leading to has not been elucidated. To this end, present study aimed explore mitophagy related induced by through in vitro vivo experiments. Male C57BL/6 mice were fed a standard rodent pellet exposed daily (20 μg/kg·bw) via intraperitoneal injections 7 days. Moreover, HEK 293 cells treated μM) 24 h. The histopathological results exhibited after exposure, characterized structurally damaged nephrotomies, inflammatory cell infiltration. Similarly, significant increase interstitial fibrosis was observed kidneys MC-LR-treated compared those control group (CT) mice. exposure caused impaired function, markedly increased blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA) Ultrastructural analysis obviously swollen, broken, disappearing mitochondrial crests, partial vacuoles cells. Western blotting demonstrated significantly protein expressions MKK6, p-p38, p62, while expression mitophagy-related proteins inhibited HEK293 cells, including parkin, TOM20, LC3-II, indicating inhibition mitophagy. Therefore, our data suggest MKK6-mediated might be toxicological toxicity acute MC-LR.

Язык: Английский

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Multi-omics analysis reveals the toxic mechanism of ammonia-enhanced Microcystis aeruginosa exposure causing liver fat deposition and muscle nutrient loss in zebrafish

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132631 - 132631

Опубликована: Сен. 26, 2023

Язык: Английский

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Life cycle assessment of integrated microalgae oil production in Bojongsoang Wastewater Treatment Plant, Indonesia

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(5), С. 7902 - 7933

Опубликована: Янв. 3, 2024

Язык: Английский

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Pleurotus ostreatus polysaccharide-mediated modulation of skin damage caused by microcystin-LR in tadpoles

Environmental Pollution, Год журнала: 2024, Номер 345, С. 123440 - 123440

Опубликована: Янв. 28, 2024

Язык: Английский

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