Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 256, С. 114852 - 114852

Опубликована: Апрель 5, 2023

Antimony (Sb) poses a significant threat to human health due sharp increases in its exploitation and application globally, but few studies have explored the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure. We established an vivo model comprehensively explore endogenous underlying liver injury short-term Adult female male Sprague-Dawley rats were orally administrated various concentrations potassium antimony tartrate for 28 days. After exposure, serum concentration, liver-to-body weight ratio, glucose levels significantly increased dose-dependent manner. Body gain biomarkers hepatic (e.g., total cholesterol, protein, alkaline phosphatase, aspartate aminotransferase/alanine aminotransferase ratio) decreased with increasing Through integrative non-targeted metabolome lipidome analyses, alanine, aspartate, glutamate metabolism; phosphatidylcholines; sphingomyelins; phosphatidylinositols most affected pathways exposed Sb. Additionally, correlation analysis showed that certain metabolites lipids deoxycholic acid, N-methylproline, palmitoylcarnitine, glycerophospholipids, sphingomyelins, glycerol) associated biomarkers, indicating metabolic remodeling may be involved apical hepatotoxicity. Our study demonstrated exposure induces hepatotoxicity, possibly through glycolipid metabolism disorder, providing important reference risks pollution.

Язык: Английский

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Correlation and interaction between urinary metals level and diabetes: A cross sectional study of community-dwelling elderly

Exposure and Health, Год журнала: 2023, Номер 16(2), С. 559 - 574

Опубликована: Июль 14, 2023

Язык: Английский

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The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 263, С. 115289 - 115289

Опубликована: Июль 25, 2023

Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object this study was to examine associations single metals and with FPG in Chinese community-dwelling people.The recruited 2348 total. Inductively coupled plasma-mass spectrometry adopted detect vanadium (V), selenium (Se), magnesium (Mg), cobalt (Co), calcium (Ca), molybdenum (Mo) urine. relationships between were evaluated by linear regression Bayesian kernel machine (BKMR) models, respectively.In multiple-metal urine V Mg negatively related (β = - 0.016, 95 % CI: 0.030 0.003 for V; β 0.021, 0.033 0.009 Mg), Se positively 0.024, 0.014-0.034). In BKMR model, significant also found. associated a dose-response pattern, had maximum posterior inclusion probability (PIP) value (PIP 1.0000), followed 0.9968). Besides, Co showed association decreased older adults without hyperlipemia women.Both levels, individually as mixture. displayed relationship reduced having largest contribution Se. Further prospective investigations necessary validate these exploratory findings.

Язык: Английский

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Association of multiple serum minerals and vitamins with metabolic dysfunction-associated fatty liver disease in US adults: National Health and Nutrition Examination Survey 2017–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Март 18, 2024

Background Despite the rapid increase in global prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD), there are no approved therapeutic drugs for MAFLD yet. Nutrient supplementation might mitigate risk MAFLD. It is more typical individuals to consume multiple nutrients simultaneously. However, studies exploring combined effects on limited. This study aimed investigate relationship between both individual and their influence Methods Data were obtained from National Health Nutrition Examination Survey (NHANES), 18 types considered this study. Logistic regression analysis was performed evaluate correlation single The Least Absolute Shrinkage Selection Operator (LASSO) pinpoint most relevant nutrient associated with Subsequently, Weighted Quantile Sum (WQS) g-computation (Qgcomp) used assess Results A total 3,069 participants included LASSO showed that Se, α-tocopherol, γ-tocopherol exhibited a positive association In contrast, serum levels Co, P, α-cryptoxanthin, LZ, trans-β-carotene inversely When Se two vitamin E excluded, WQS index significant inverse remaining 15 MAFLD; α-cryptoxanthin substantial contribution. Similarly, Qgcomp suggested these lower MAFLD, possessing negative weights. Conclusion complex either low proportion or without them should be recommended patients reduce its risk.

Язык: Английский

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Associations of metals and metal mixtures with glucose homeostasis: A combined bibliometric and epidemiological study

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134224 - 134224

Опубликована: Апрель 5, 2024

Язык: Английский

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