Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29684 - e29684
Опубликована: Апрель 1, 2024
Phthalates,
widely
utilized
in
industrial
products,
are
classified
as
endocrine-disrupting
chemicals
(EDCs).
Although
certain
phthalate
and
their
metabolites
have
been
implicated
cancer
development,
the
reported
findings
exhibited
inconsistencies.
Therefore,
we
conducted
comprehensive
literature
search
to
assess
association
between
risk
by
identifying
original
studies
measuring
phthalates
or
reporting
correlation
with
until
July
4,
2023.
The
Odds
Ratios
(ORs)
corresponding
95%
confidence
intervals
(CIs)
were
extracted
analyzed
estimate
risk.
Pooled
data
from
eleven
studies,
including
3101
patients
6858
controls,
using
a
fixed-
random-effects
model
based
on
heterogeneity
tests.
When
comparing
extreme
categories
of
different
metabolites,
observed
significant
urinary
(MEHHP,
MECPP,
DBP
MBzP)
our
meta-analysis
reinforce
existing
evidence
that
is
strongly
associated
development.
Further
investigations
warranted
elucidate
underlying
mechanisms
this
association.
These
results
may
offer
novel
insights
into
Frontiers in Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 6, 2023
Traditional
plastics,
such
as
polyethylene
(PE),
polystyrene
(PS),
polypropylene
(PP),
polyvinyl
chloride
(PVC),
terephthalate
(PET),
polyurethane
(PUR),
and
other
plastic
polymers,
are
difficult
to
degrade
gradually
accumulated
in
the
environment
cause
a
serious
environmental
problem,
which
is
urgently
needed
develop
novel
treatments
or
control
technology.
The
biodegradation
of
plastics
has
gained
great
attention
due
advantages
green
safe
characteristics.
Microorganisms
play
vital
role
including
microbes
(
vitro
)
gut
insects
vivo
).
Microbial
degradation
conditions
extremely
slow
for
major
at
rates
on
basis
month
even
year
time,
but
recent
discoveries
show
that
fast
specific
PS,
PE,
PUR,
some
invertebrates,
especially
insects,
could
be
enhanced
hours;
likely
microbial-dependent
synergetic
bioreactions
animal
digestive
systems.
This
review
comprehensively
summarizes
latest
7-year
(2016–2022)
publications
by
microorganisms,
elucidates
mechanism
microbes,
highlights
cutting-edge
perspectives
potential
applications
biodegradation.
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology,
Год журнала:
2023,
Номер
270, С. 109645 - 109645
Опубликована: Май 5, 2023
Plastics,
long-chain
artificial
polymers,
are
used
worldwide
with
a
global
production
of
350
million
tonnes
per
year.
Various
degradation
processes
transform
plastics
into
smaller
fragments
divided
micro,
meso
and
macroplastics.
In
various
industries,
such
as
construction,
certain
plastic
additives
to
improve
flexibility
enhance
performance.
Plastic
include
phthalates
(PAE),
dibutyl
phthalate
(DPB)
diethyl
(DEP).
Due
the
use
additives,
these
small
different
shapes
colours
present
in
all
environmental
compartments.
For
their
characteristics,
PAEs
can
be
introduced
particularly
by
ingestion,
inhalation
dermal
absorption.
They
accumulate
human
body,
where
they
have
already
been
identified
blood,
amniotic
fluid
urine.
The
purpose
this
review
is
gather
effects
that
on
systems
body.
Being
endocrine
disruptors,
erythrocytes
how
considered
targets
for
xenobiotics
analysed.
influence
reproductive
system
was
also
examined.
Phthalates
therefore
often
overused.
properties,
reach
tissues
negative
impact
health.
aim
give
an
overview
presence
hazards.
Therefore,
should
reduced,
replaced
disposal
improved.
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(17), С. 6876 - 6887
Опубликована: Апрель 21, 2023
Plastics–microorganism
interactions
have
aroused
growing
environmental
and
ecological
concerns.
However,
previous
studies
concentrated
mainly
on
the
direct
paid
little
attention
to
ecotoxicology
effects
of
phthalates
(PAEs),
a
common
plastic
additive
that
is
continuously
released
accumulates
in
environment.
Here,
we
provide
insights
into
impacts
PAEs
dissemination
antibiotic
resistance
genes
(ARGs)
among
microorganisms.
Dimethyl
phthalate
(DMP,
model
PAE)
at
environmentally
relevant
concentrations
(2–50
μg/L)
significantly
boosted
plasmid-mediated
conjugation
transfer
ARGs
intrageneric,
intergeneric,
wastewater
microbiota
by
up
3.82,
4.96,
4.77
times,
respectively.
The
experimental
molecular
dynamics
simulation
results
unveil
strong
interaction
between
DMP
molecules
phosphatidylcholine
bilayer
cell
membrane,
which
lowers
membrane
lipid
fluidity
increases
permeability
favor
ARGs.
In
addition,
increased
reactive
oxygen
species
generation
conjugation-associated
gene
overexpression
under
stress
also
contribute
transfer.
This
study
provides
fundamental
knowledge
PAE–bacteria
broaden
our
understanding
risks
plastics,
especially
niches
with
colonized
microbes,
guide
control
ARG
spreading.
