Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29684 - e29684
Опубликована: Апрель 1, 2024
Phthalates,
widely
utilized
in
industrial
products,
are
classified
as
endocrine-disrupting
chemicals
(EDCs).
Although
certain
phthalate
and
their
metabolites
have
been
implicated
cancer
development,
the
reported
findings
exhibited
inconsistencies.
Therefore,
we
conducted
comprehensive
literature
search
to
assess
association
between
risk
by
identifying
original
studies
measuring
phthalates
or
reporting
correlation
with
until
July
4,
2023.
The
Odds
Ratios
(ORs)
corresponding
95%
confidence
intervals
(CIs)
were
extracted
analyzed
estimate
risk.
Pooled
data
from
eleven
studies,
including
3101
patients
6858
controls,
using
a
fixed-
random-effects
model
based
on
heterogeneity
tests.
When
comparing
extreme
categories
of
different
metabolites,
observed
significant
urinary
(MEHHP,
MECPP,
DBP
MBzP)
our
meta-analysis
reinforce
existing
evidence
that
is
strongly
associated
development.
Further
investigations
warranted
elucidate
underlying
mechanisms
this
association.
These
results
may
offer
novel
insights
into
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29684 - e29684
Опубликована: Апрель 1, 2024
Phthalates,
widely
utilized
in
industrial
products,
are
classified
as
endocrine-disrupting
chemicals
(EDCs).
Although
certain
phthalate
and
their
metabolites
have
been
implicated
cancer
development,
the
reported
findings
exhibited
inconsistencies.
Therefore,
we
conducted
comprehensive
literature
search
to
assess
association
between
risk
by
identifying
original
studies
measuring
phthalates
or
reporting
correlation
with
until
July
4,
2023.
The
Odds
Ratios
(ORs)
corresponding
95%
confidence
intervals
(CIs)
were
extracted
analyzed
estimate
risk.
Pooled
data
from
eleven
studies,
including
3101
patients
6858
controls,
using
a
fixed-
random-effects
model
based
on
heterogeneity
tests.
When
comparing
extreme
categories
of
different
metabolites,
observed
significant
urinary
(MEHHP,
MECPP,
DBP
MBzP)
our
meta-analysis
reinforce
existing
evidence
that
is
strongly
associated
development.
Further
investigations
warranted
elucidate
underlying
mechanisms
this
association.
These
results
may
offer
novel
insights
into