Heliyon,
Journal Year:
2024,
Volume and Issue:
10(8), P. e29684 - e29684
Published: April 1, 2024
Phthalates,
widely
utilized
in
industrial
products,
are
classified
as
endocrine-disrupting
chemicals
(EDCs).
Although
certain
phthalate
and
their
metabolites
have
been
implicated
cancer
development,
the
reported
findings
exhibited
inconsistencies.
Therefore,
we
conducted
comprehensive
literature
search
to
assess
association
between
risk
by
identifying
original
studies
measuring
phthalates
or
reporting
correlation
with
until
July
4,
2023.
The
Odds
Ratios
(ORs)
corresponding
95%
confidence
intervals
(CIs)
were
extracted
analyzed
estimate
risk.
Pooled
data
from
eleven
studies,
including
3101
patients
6858
controls,
using
a
fixed-
random-effects
model
based
on
heterogeneity
tests.
When
comparing
extreme
categories
of
different
metabolites,
observed
significant
urinary
(MEHHP,
MECPP,
DBP
MBzP)
our
meta-analysis
reinforce
existing
evidence
that
is
strongly
associated
development.
Further
investigations
warranted
elucidate
underlying
mechanisms
this
association.
These
results
may
offer
novel
insights
into
Journal of Hazardous Materials,
Journal Year:
2023,
Volume and Issue:
458, P. 131810 - 131810
Published: June 9, 2023
The
current
study
investigated
the
chemical
complexity
of
fifty
plastic
(36)
and
elastomer/rubber
(14)
methanol
extracts
from
consumer
products,
focusing
on
association
with
toxicity
in
two
screening
assays
(bacteria
luminescence
marine
microalgae).
composition
varied
considerably
between
products
polymers.
most
complex
sample
(car
tire
rubber)
contained
2456
features
least
(disposable
water
bottle)
only
39
features,
a
median
386
across
all
products.
Individual
extract
also
significantly
polymers,
showing
comparable
results
terms
defining
low
high
extracts,
correlation
medium
extracts.
Chemical
abundance
both
correlated
assays.
However,
there
were
strong
differences
elastomer
Overall,
86-93
%
14
33-36
other
polymer
(n
=
36)
more
toxic
than
median.
A
range
compounds
tentatively
identified
set,
several
concerning
being
identified,
mostly
elastomers.
While
focus
chemicals
is
towards
thermoplastics,
we
show
that
elastomers
may
be
concern
an
environmental
human
health
perspective.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(8), P. e29684 - e29684
Published: April 1, 2024
Phthalates,
widely
utilized
in
industrial
products,
are
classified
as
endocrine-disrupting
chemicals
(EDCs).
Although
certain
phthalate
and
their
metabolites
have
been
implicated
cancer
development,
the
reported
findings
exhibited
inconsistencies.
Therefore,
we
conducted
comprehensive
literature
search
to
assess
association
between
risk
by
identifying
original
studies
measuring
phthalates
or
reporting
correlation
with
until
July
4,
2023.
The
Odds
Ratios
(ORs)
corresponding
95%
confidence
intervals
(CIs)
were
extracted
analyzed
estimate
risk.
Pooled
data
from
eleven
studies,
including
3101
patients
6858
controls,
using
a
fixed-
random-effects
model
based
on
heterogeneity
tests.
When
comparing
extreme
categories
of
different
metabolites,
observed
significant
urinary
(MEHHP,
MECPP,
DBP
MBzP)
our
meta-analysis
reinforce
existing
evidence
that
is
strongly
associated
development.
Further
investigations
warranted
elucidate
underlying
mechanisms
this
association.
These
results
may
offer
novel
insights
into
