Optimizing Drug Development: Harnessing the Sustainability of Pharmaceutical Cocrystals DOI
Srinivasulu Aitipamula, Geetha Bolla

Molecular Pharmaceutics, Год журнала: 2024, Номер 21(7), С. 3121 - 3143

Опубликована: Май 30, 2024

Environmental impacts of the industrial revolution necessitate adoption sustainable practices in all areas development. The pharmaceutical industry faces increasing pressure to minimize its ecological footprint due significant contribution environmental pollution. Over past two decades, cocrystals have received immense popularity their ability optimize critical attributes active ingredients and presented an avenue bring improved drug products market. This review explores potential as ecofriendly alternative traditional solid forms, offering a approach From reducing number required doses improving stability actives, from eliminating synthetic operations using pharmaceutically approved chemicals, use continuous solvent-free manufacturing methods leveraging published data on safety toxicology, cocrystallization contributes sustainability latest trends suggest promising role bringing novel medicines market, which has been further fuelled by recent guidance major regulatory agencies.

Язык: Английский

Propyl paraben removal using Cu2O/ZnO-NPs photocatalyst elaborated via green method DOI

Bilal Chikhi,

Meriem Gouasmi,

Alaimia Mounia

и другие.

Environmental Science and Pollution Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Язык: Английский

Процитировано

2

Toxicity and removal of parabens from water: A critical review DOI
Nathaniel B. Bolujoko, Emmanuel I. Unuabonah, Moses O. Alfred

и другие.

The Science of The Total Environment, Год журнала: 2021, Номер 792, С. 148092 - 148092

Опубликована: Май 29, 2021

Язык: Английский

Процитировано

93

Parabens as emerging contaminants: Environmental persistence, current practices and treatment processes DOI Creative Commons
Francisca Vale, Cátia A. Sousa, Henrique Sousa

и другие.

Journal of Cleaner Production, Год журнала: 2022, Номер 347, С. 131244 - 131244

Опубликована: Март 9, 2022

The unmatched levels of water contamination by emerging contaminants (ECs), such as endocrine disrupting compounds (EDCs) and pharmaceuticals, has become a relevant environmental problem due to their considerable ecotoxicity associated health issues. Among the EDCs, parabens are group preservative widely used on daily basis in cosmetic, personal care products, food products pharmaceuticals. Parabens can cause variety adverse effects, particularly system. They frequently detected matrices (up 170.9 μg/L surface waters), with critical presence persistence aquatic systems 36,000 h half-life time). Despite advances wastewater treatment technologies, design existing plants is not suited remove these ECs, generating wastes containing high concentrations persistent or chemically unstable demand amounts energy for operation. Moreover, there lack published standards that provide guidelines treating parabens, highlighting need innovative approaches. Microalgae bioremediation starting evolve scientifically feasible removal namely laboratorial pilot scale studies achieving efficiencies close 100%. However, large microalgae-based wastewaters other ECs faces challenges process optimization. This study reviews physicochemical properties regulation persistence. It further provides rigorous analysis comparison systems, reinforcing research.

Язык: Английский

Процитировано

69

Assessment of Thyroid Endocrine Disruption Effects of Parabens Using In Vivo, In Vitro, and In Silico Approaches DOI

Jiefeng Liang,

Xiaoxi Yang, Qian S. Liu

и другие.

Environmental Science & Technology, Год журнала: 2021, Номер 56(1), С. 460 - 469

Опубликована: Дек. 21, 2021

The extensive applications of parabens in foods, drugs, and cosmetics cause inevitable exposure to humans. Revealing the developmental toxicity is utmost importance regarding their safety evaluation. In this study, effects four commonly used parabens, including methyl paraben (20 ∼ 200 μM), ethyl 100 propyl (5 20 butyl (BuP, 2 10 were investigated on early development zebrafish embryos larvae. underlying mechanisms explored from aspect disturbance thyroid endocrine system using vivo, vitro, silico assays. Paraben caused deleterious zebrafish, with BuP displaying highest among all, resulting concentration-related mortality, decreased hatching rate, reduced body length, lowered heart incidence malformation. Further investigation showed that hormone levels disturbed transcriptional expressions target genes hypothalamic–pituitary–thyroid axis. Molecular docking analysis combined vitro GH3 cell proliferation assay testified all test exhibited receptor agonistic activities. findings confirmed disruption effects, providing substantial evidence control paraben-based preservatives.

Язык: Английский

Процитировано

65

Mass trends of parabens, triclocarban and triclosan in Arizona wastewater collected after the 2017 FDA ban on antimicrobials and during the COVID-19 pandemic DOI
Sangeet Adhikari, Rahul Kumar, Erin M. Driver

и другие.

Water Research, Год журнала: 2022, Номер 222, С. 118894 - 118894

Опубликована: Июль 23, 2022

Язык: Английский

Процитировано

43

Carbon quantum dots (CQDs) mediated Z-scheme g–C3N4–CQDs/BiVO4 heterojunction with enhanced visible light photocatalytic degradation of Paraben DOI

Maosheng Tian,

Chenyan Hu, Junxia Yu

и другие.

Chemosphere, Год журнала: 2023, Номер 323, С. 138248 - 138248

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

40

Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation DOI Open Access
Priyanka Rathee, Renu Sehrawat, Pooja Rathee

и другие.

Materials, Год журнала: 2023, Номер 16(13), С. 4793 - 4793

Опубликована: Июль 3, 2023

The global market of food, cosmetics, and pharmaceutical products requires continuous tracking harmful ingredients microbial contamination for the sake safety both consumers as these greatly dominate consumer’s health, directly or indirectly. existence, survival, growth microorganisms in product may lead to physicochemical degradation spoilage infect consumer at another end. It has become a challenge industries produce that is safe, self-stable, high nutritional value, many factors such physical, chemical, enzymatic, activities are responsible causing within due course time. Thus, preservatives added retain virtue ensure its consumer. Nowadays, use synthetic/artificial common not been widely accepted by they aware fact exposure can adverse effects on which major area concern researchers. Naturally occurring phenolic compounds appear be extensively used bio-preservatives prolong shelf life finished product. Based convincing shreds evidence reported literature, it suggested their derivatives have massive potential investigated development new moieties proven promising drug molecules. objective this article provide an overview significant role preservation perishable from attack exclusive antioxidant free radical scavenging properties problems associated with synthetic products. This also analyzes recent trends along technical norms regulate cosmetic, developing countries.

Язык: Английский

Процитировано

38

Parabens as environmental contaminants of aquatic systems affecting water quality and microbial dynamics DOI Creative Commons
Ana Rita Pereira, Manuel Simões, Inês B. Gomes

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 905, С. 167332 - 167332

Опубликована: Сен. 25, 2023

Among different pollutants of emerging concern, parabens have gained rising interest due to their widespread detection in water sources worldwide. This occurs because are used personal care products, pharmaceuticals, and food, which residues generated released into aquatic environments. The regulation the use varies across geographic regions, resulting diverse concentrations observed globally. Concentrations exceeding 100 μg/L been found wastewater treatment plants surface waters while drinking (DW) typically exhibit below 6 μg/L. Despite low levels, presence DW is a potential exposure route for humans, raising concerns both human health environmental microbiota. Although few studies reported alterations functions characteristics microbial communities following contaminants, impact by communities, particularly biofilm colonizers, remains largely understudied. review gathers most recent information on occurrence sources, as well effects organisms. interactions with reviewed first time, filling knowledge gaps paraben ecosystems disinfection tolerance antimicrobial resistance, implications public health.

Язык: Английский

Процитировано

30

Comparison between pollutants found in breast milk and infant formula in the last decade: A review DOI Creative Commons
Irene Martín-Carrasco,

Pilar Carbonero-Aguilar,

Bouchra Dahiri

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 875, С. 162461 - 162461

Опубликована: Март 1, 2023

Since ancient times, breastfeeding has been the fundamental way of nurturing newborn. The benefits breast milk are widely known, as it is a source essential nutrients and provides immunological protection, well developmental benefits, among others. However, when not possible, infant formula most appropriate alternative. Its composition meets nutritional requirements infant, its quality subject to strict control by authorities. Nonetheless, presence different pollutants detected in both matrices. Thus, aim present review make comparison between findings terms contaminants last decade, order choose convenient option depending on environmental conditions. For that, emerging including metals, chemical compounds derived from heat treatment, pharmaceutical drugs, mycotoxins, pesticides, packaging materials, other were described. While concerning found metals such materials outstanding. In conclusion, convenience using feeding diet based or either depends maternal circumstances. important take into account compared formula, possibility combination with fulfilled only intake milk. Therefore, more attention should be paid analyzing these conditions each case able proper decision, will vary newborn environment.

Язык: Английский

Процитировано

28

Yeast surface display technology: Mechanisms, applications, and perspectives DOI
Yibo Li, Xu Wang, Ning‐Yi Zhou

и другие.

Biotechnology Advances, Год журнала: 2024, Номер 76, С. 108422 - 108422

Опубликована: Авг. 6, 2024

Язык: Английский

Процитировано

12