Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(7), P. 3121 - 3143
Published: May 30, 2024
Environmental
impacts
of
the
industrial
revolution
necessitate
adoption
sustainable
practices
in
all
areas
development.
The
pharmaceutical
industry
faces
increasing
pressure
to
minimize
its
ecological
footprint
due
significant
contribution
environmental
pollution.
Over
past
two
decades,
cocrystals
have
received
immense
popularity
their
ability
optimize
critical
attributes
active
ingredients
and
presented
an
avenue
bring
improved
drug
products
market.
This
review
explores
potential
as
ecofriendly
alternative
traditional
solid
forms,
offering
a
approach
From
reducing
number
required
doses
improving
stability
actives,
from
eliminating
synthetic
operations
using
pharmaceutically
approved
chemicals,
use
continuous
solvent-free
manufacturing
methods
leveraging
published
data
on
safety
toxicology,
cocrystallization
contributes
sustainability
latest
trends
suggest
promising
role
bringing
novel
medicines
market,
which
has
been
further
fuelled
by
recent
guidance
major
regulatory
agencies.
Journal of Cleaner Production,
Journal Year:
2022,
Volume and Issue:
347, P. 131244 - 131244
Published: March 9, 2022
The
unmatched
levels
of
water
contamination
by
emerging
contaminants
(ECs),
such
as
endocrine
disrupting
compounds
(EDCs)
and
pharmaceuticals,
has
become
a
relevant
environmental
problem
due
to
their
considerable
ecotoxicity
associated
health
issues.
Among
the
EDCs,
parabens
are
group
preservative
widely
used
on
daily
basis
in
cosmetic,
personal
care
products,
food
products
pharmaceuticals.
Parabens
can
cause
variety
adverse
effects,
particularly
system.
They
frequently
detected
matrices
(up
170.9
μg/L
surface
waters),
with
critical
presence
persistence
aquatic
systems
36,000
h
half-life
time).
Despite
advances
wastewater
treatment
technologies,
design
existing
plants
is
not
suited
remove
these
ECs,
generating
wastes
containing
high
concentrations
persistent
or
chemically
unstable
demand
amounts
energy
for
operation.
Moreover,
there
lack
published
standards
that
provide
guidelines
treating
parabens,
highlighting
need
innovative
approaches.
Microalgae
bioremediation
starting
evolve
scientifically
feasible
removal
namely
laboratorial
pilot
scale
studies
achieving
efficiencies
close
100%.
However,
large
microalgae-based
wastewaters
other
ECs
faces
challenges
process
optimization.
This
study
reviews
physicochemical
properties
regulation
persistence.
It
further
provides
rigorous
analysis
comparison
systems,
reinforcing
research.
Environmental Science & Technology,
Journal Year:
2021,
Volume and Issue:
56(1), P. 460 - 469
Published: Dec. 21, 2021
The
extensive
applications
of
parabens
in
foods,
drugs,
and
cosmetics
cause
inevitable
exposure
to
humans.
Revealing
the
developmental
toxicity
is
utmost
importance
regarding
their
safety
evaluation.
In
this
study,
effects
four
commonly
used
parabens,
including
methyl
paraben
(20
∼
200
μM),
ethyl
100
propyl
(5
20
butyl
(BuP,
2
10
were
investigated
on
early
development
zebrafish
embryos
larvae.
underlying
mechanisms
explored
from
aspect
disturbance
thyroid
endocrine
system
using
vivo,
vitro,
silico
assays.
Paraben
caused
deleterious
zebrafish,
with
BuP
displaying
highest
among
all,
resulting
concentration-related
mortality,
decreased
hatching
rate,
reduced
body
length,
lowered
heart
incidence
malformation.
Further
investigation
showed
that
hormone
levels
disturbed
transcriptional
expressions
target
genes
hypothalamic–pituitary–thyroid
axis.
Molecular
docking
analysis
combined
vitro
GH3
cell
proliferation
assay
testified
all
test
exhibited
receptor
agonistic
activities.
findings
confirmed
disruption
effects,
providing
substantial
evidence
control
paraben-based
preservatives.
Materials,
Journal Year:
2023,
Volume and Issue:
16(13), P. 4793 - 4793
Published: July 3, 2023
The
global
market
of
food,
cosmetics,
and
pharmaceutical
products
requires
continuous
tracking
harmful
ingredients
microbial
contamination
for
the
sake
safety
both
consumers
as
these
greatly
dominate
consumer’s
health,
directly
or
indirectly.
existence,
survival,
growth
microorganisms
in
product
may
lead
to
physicochemical
degradation
spoilage
infect
consumer
at
another
end.
It
has
become
a
challenge
industries
produce
that
is
safe,
self-stable,
high
nutritional
value,
many
factors
such
physical,
chemical,
enzymatic,
activities
are
responsible
causing
within
due
course
time.
Thus,
preservatives
added
retain
virtue
ensure
its
consumer.
Nowadays,
use
synthetic/artificial
common
not
been
widely
accepted
by
they
aware
fact
exposure
can
adverse
effects
on
which
major
area
concern
researchers.
Naturally
occurring
phenolic
compounds
appear
be
extensively
used
bio-preservatives
prolong
shelf
life
finished
product.
Based
convincing
shreds
evidence
reported
literature,
it
suggested
their
derivatives
have
massive
potential
investigated
development
new
moieties
proven
promising
drug
molecules.
objective
this
article
provide
an
overview
significant
role
preservation
perishable
from
attack
exclusive
antioxidant
free
radical
scavenging
properties
problems
associated
with
synthetic
products.
This
also
analyzes
recent
trends
along
technical
norms
regulate
cosmetic,
developing
countries.
The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
905, P. 167332 - 167332
Published: Sept. 25, 2023
Among
different
pollutants
of
emerging
concern,
parabens
have
gained
rising
interest
due
to
their
widespread
detection
in
water
sources
worldwide.
This
occurs
because
are
used
personal
care
products,
pharmaceuticals,
and
food,
which
residues
generated
released
into
aquatic
environments.
The
regulation
the
use
varies
across
geographic
regions,
resulting
diverse
concentrations
observed
globally.
Concentrations
exceeding
100
μg/L
been
found
wastewater
treatment
plants
surface
waters
while
drinking
(DW)
typically
exhibit
below
6
μg/L.
Despite
low
levels,
presence
DW
is
a
potential
exposure
route
for
humans,
raising
concerns
both
human
health
environmental
microbiota.
Although
few
studies
reported
alterations
functions
characteristics
microbial
communities
following
contaminants,
impact
by
communities,
particularly
biofilm
colonizers,
remains
largely
understudied.
review
gathers
most
recent
information
on
occurrence
sources,
as
well
effects
organisms.
interactions
with
reviewed
first
time,
filling
knowledge
gaps
paraben
ecosystems
disinfection
tolerance
antimicrobial
resistance,
implications
public
health.
The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
875, P. 162461 - 162461
Published: March 1, 2023
Since
ancient
times,
breastfeeding
has
been
the
fundamental
way
of
nurturing
newborn.
The
benefits
breast
milk
are
widely
known,
as
it
is
a
source
essential
nutrients
and
provides
immunological
protection,
well
developmental
benefits,
among
others.
However,
when
not
possible,
infant
formula
most
appropriate
alternative.
Its
composition
meets
nutritional
requirements
infant,
its
quality
subject
to
strict
control
by
authorities.
Nonetheless,
presence
different
pollutants
detected
in
both
matrices.
Thus,
aim
present
review
make
comparison
between
findings
terms
contaminants
last
decade,
order
choose
convenient
option
depending
on
environmental
conditions.
For
that,
emerging
including
metals,
chemical
compounds
derived
from
heat
treatment,
pharmaceutical
drugs,
mycotoxins,
pesticides,
packaging
materials,
other
were
described.
While
concerning
found
metals
such
materials
outstanding.
In
conclusion,
convenience
using
feeding
diet
based
or
either
depends
maternal
circumstances.
important
take
into
account
compared
formula,
possibility
combination
with
fulfilled
only
intake
milk.
Therefore,
more
attention
should
be
paid
analyzing
these
conditions
each
case
able
proper
decision,
will
vary
newborn
environment.
