Chemosphere, Год журнала: 2023, Номер 337, С. 139277 - 139277
Опубликована: Июнь 24, 2023
Язык: Английский
Nature, Год журнала: 2021, Номер 600(7889), С. 456 - 461
Опубликована: Дек. 15, 2021
Язык: Английский
Процитировано
131
Frontiers in Nutrition, Год журнала: 2022, Номер 9
Опубликована: Ноя. 3, 2022
Bisphenol A (BPA) is a synthetic chemical widely employed to synthesize epoxy resins, polymer materials, and polycarbonate plastics. BPA abundant in the environment, i.e., food containers, water bottles, thermal papers, toys, medical devices, etc., incorporated into soil/water through leaching. Being potent endocrine disrupter, has potential alter several body mechanisms. Studies confirmed its anti-androgen action estrogen-like effects, which impart many negative health impacts, especially on immune system, neuroendocrine process, reproductive mechanism. Moreover, it can also induce mutagenesis carcinogenesis, as per recent scientific research. This review focuses BPA's presence concentrations different environments, sources basic mechanisms of BPA-induced toxicity disruptions. It unique type because association cancer, hormonal disruption, immunosuppression, infertility with BPA. These issues are widespread today, significantly contributes their incidence wide usage daily life utensils other accessories. The discusses researched-based measures cope toxic chemical.
Язык: Английский
Процитировано
111
Chemosphere, Год журнала: 2023, Номер 315, С. 137763 - 137763
Опубликована: Янв. 6, 2023
Язык: Английский
Процитировано
109
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2022, Номер 254, С. 109275 - 109275
Опубликована: Янв. 22, 2022
Язык: Английский
Процитировано
102
Integrated Environmental Assessment and Management, Год журнала: 2022, Номер 19(1), С. 45 - 62
Опубликована: Апрель 1, 2022
With over 95% of bisphenol-A (BPA) used in the production polycarbonate (PC) and epoxy resins, termed here as BPA-based plastic materials, components, products (MCPs), an investigation human exposure to BPA whole lifecycle MCPs is necessary. This mini-review unpacks implications arising from long-term its potential accumulation across plastics (production, use, management). timely necessary promoting a sustainable circular economy model. Restrictions form bans safety standards are often specific products, while limits rely on traditional toxicological biomonitoring methods that may underestimate health therefore "safety" exposure. Controversies regards the: (a) dose-response curves; (b) complexity sources, release mechanisms, pathways exposure; and/or (c) quality reliability studies, appear currently stifle progress toward regulation MCPs. Due abundance our production, consumption, management systems, there partial inadequate evidence contribution BPA. Yet, end-of-life constitute most critical source require further investigation. Active collaboration among risk assessors, government, policy-makers, researchers needed explore impacts long term introduce restrictions Integr Environ Assess Manag 2023;19:45-62. © 2022 SETAC.
Язык: Английский
Процитировано
89
Journal of the Endocrine Society, Год журнала: 2024, Номер 8(2)
Опубликована: Янв. 5, 2024
Abstract Context Chemicals used in plastics have been described to contribute disease and disability, but attributable fractions not quantified assess specific contributions. Without this information, interventions proposed as part of the Global Plastics Treaty cannot be evaluated for potential benefits. Objective To accurately inform tradeoffs involved ongoing reliance on plastic production a source economic productivity United States, we calculated burden cost due chemicals materials 2018. Methods We first analyzed existing literature identify plastic-related (PRF) disability polybrominated diphenylethers (PBDE), phthalates, bisphenols, polyfluoroalkyl substances perfluoroalkyl (PFAS). then updated previously published estimates these States By uniting data, computed costs States. Results identified PRFs 97.5% bisphenol A (96.25-98.75% sensitivity analysis), 98% (96%-99%) di-2-ethylhexylphthalate, 100% (71%-100%) butyl phthalates benzyl (97%-99%) PBDE-47, 93% (16%-96%) PFAS. In total, estimate $249 billion (sensitivity analysis: $226 billion-$289 billion) plastic-attributable The majority arose result PBDE exposure, though $66.7 ($64.7 billion-67.3 was phthalate exposure $22.4 PFAS $3.85-$60.1 billion). Conclusion substantially associated social accounting 1.22% gross domestic product. pollution will continue accumulate long exposures at current levels. Actions through other policy initiatives reduce proportion actual reductions chemical achieved.
Язык: Английский
Процитировано
30
Food Chemistry, Год журнала: 2024, Номер 443, С. 138499 - 138499
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
22
EFSA Journal, Год журнала: 2024, Номер 22(7)
Опубликована: Июль 1, 2024
The European Commission asked EFSA to update its 2011 risk assessment on tetrabromobisphenol A (TBBPA) and five derivatives in food. Neurotoxicity carcinogenicity were considered as the critical effects of TBBPA rodent studies. available evidence indicates that occurs via non-genotoxic mechanisms. Taking into account new data, CONTAM Panel it appropriate set a tolerable daily intake (TDI). Based decreased interest social interaction male mice, lowest observed adverse effect level (LOAEL) 0.2 mg/kg body weight (bw) per day was identified selected reference point for characterisation. Applying default uncertainty factor 100 inter- intraspecies variability, 3 extrapolate from LOAEL NOAEL, TDI 0.7 μg/kg bw established. Around 2100 analytical results food used estimate dietary exposure population. most important contributors chronic LB fish seafood, meat products milk dairy products. estimates all below TDI, including those estimated breastfed formula-fed infants. Accounting uncertainties affecting assessment, concluded with 90%-95% certainty current does not raise health concern any population groups considered. There insufficient data toxicity derive points, or allow comparison would support assignment an group purposes combined assessment.
Язык: Английский
Процитировано
17
Diamond and Related Materials, Год журнала: 2025, Номер unknown, С. 112036 - 112036
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Electronic Journal of General Medicine, Год журнала: 2025, Номер 22(2), С. em632 - em632
Опубликована: Фев. 13, 2025
Indoor air quality (IAQ) at educational institutions has emerged as an important public health issue, affecting the and cognitive performance of school-aged children, students, faculty alike. This scoping review study seeks to investigate synthesize current literature on factors influencing state research IAQ in its implications for health. The methodology this is with guidelines preferred reporting items extension reviews. technique thoroughly investigated peer-reviewed journals, international organizations, government reports, case studies contexts. Using keywords such IAQ; institutions; health; Europe, “adverse outcomes,” study’s inclusion exclusion criteria, well criteria use assessments. results show that poor linked various problems, including respiratory issues impairments, especially among vulnerable groups like children teachers. Inadequate ventilation, volatile organic compounds, mold growth, external contaminants are all common causes IAQ. Monitoring management measures required improve Educational Institutions, encouraging students’ academic performance. Policy also interdisciplinary approaches addressing concern.
Язык: Английский
Процитировано
2