Environmental Pollution,
Год журнала:
2022,
Номер
306, С. 119367 - 119367
Опубликована: Апрель 28, 2022
Extended-spectrum
β-lactamases
(ESBL)-producing
Enterobacterales
have
been
classified
as
critical
priority
pathogens
by
the
World
Health
Organization
(WHO).
ESBL
are
universally
distributed
and,
in
2006,
were
firstly
reported
on
a
wild
animal.
Understanding
relative
contributions
of
animals
to
circulation
environment
is
urgently
needed.
In
this
work,
we
conducted
nationwide
study
Portugal
investigate
occurrence
bacteria
carrying
clinically
significant
antimicrobial
resistance
genes
(ARG),
using
widely
ungulates
model
species.
A
total
151
resistant-Enterobacterales
isolates
detected
from
181
ungulates:
50%
(44/88)
boar
(Sus
scrofa),
40.3%
(25/62)
red
deer
(Cervus
elaphus),
41.4%
(12/29)
fallow
(Dama
dama)
and
100%
(2/2)
mouflon
(Ovis
aries
subsp.
musimon).
Selected
showed
diversified
profile,
with
particularly
high
values
corresponding
ampicillin
(71.5%)
tetracycline
(63.6%).
strains
carried
blaTEM,
tetA,
tetB,
sul2,
sul1
or
dfrA1
ARG
genes.
They
also
blaCTX-M-type
genes,
which
prevalent
human
infections,
namely
CTX-M-14,
CTX-M-15
CTX-M-98.
Strikingly,
first
report
CTX-M-98
wildlife.
Almost
40%
(n
=
59)
multi-drug
resistant.
The
diversity
plasmids
was
remarkable,
including
IncF,
K
P.
This
highlights
potential
role
environmental
reservoirs
CTX-M
ESBL-producing
E.
coli
spill-over
AMR
their
determinants.
Our
findings
suggest
that
useful
strategic
sentinel
species
terrestrial
environments,
especially
response
sources
anthropogenic
pollution,
providing
early
warning
risks
human,
animal
health.
The
polymyxin
and
lipopeptide
classes
of
antibiotics
are
membrane-targeting
drugs
last
resort
used
to
treat
infections
caused
by
multi-drug-resistant
pathogens.
Despite
similar
structures,
these
two
antibiotic
have
distinct
modes
action
clinical
uses.
polymyxins
target
lipopolysaccharide
in
the
membranes
most
Gram-negative
species
often
carbapenem-resistant
such
as
Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 29, 2022
With
the
large-scale
use
of
antibiotics,
antibiotic
resistant
bacteria
(ARB)
continue
to
rise,
and
resistance
genes
(ARGs)
are
regarded
as
emerging
environmental
pollutants.
The
new
tetracycline-class
antibiotic,
tigecycline
is
last
resort
for
treating
multidrug-resistant
(MDR)
bacteria.
Plasmid-mediated
horizontal
transfer
enables
sharing
genetic
information
among
different
gene
tet
(X)
threatens
efficacy
tigecycline,
adjacent
IS
CR2
or
26
often
detected
upstream
downstream
gene,
which
may
play
a
crucial
driving
role
in
transmission
gene.
Since
first
discovery
plasmid-mediated
high-level
(X4)
China
2019,
genes,
especially
(X4),
have
been
reported
within
various
reservoirs
worldwide,
such
ducks,
geese,
migratory
birds,
chickens,
pigs,
cattle,
aquatic
animals,
agricultural
field,
meat,
humans.
Further,
our
current
researches
also
mentioned
viruses
novel
resistance,
will
probably
become
focus
studying
ARGs.
Overall,
this
article
mainly
aims
discuss
status
particular
pollutants,
risk
public
health
“One
Health”
concept.
Letters in Applied Microbiology,
Год журнала:
2023,
Номер
76(2)
Опубликована: Фев. 1, 2023
Multidrug-resistant
(MDR)
Escherichia
coli
strains
have
rapidly
increased
worldwide,
and
effective
antibiotic
therapeutic
options
are
becoming
more
restricted.
As
a
polymyxin
antibiotic,
colistin
has
long
history
of
usage,
it
is
used
as
final
line
treatment
for
severe
infections
by
Gram-negative
bacteria
(GNB)
with
high-level
resistance.
However,
its
application
been
challenged
the
emergence
E.
Hence,
determining
mechanism
that
confers
resistance
crucial
monitoring
controlling
dissemination
colistin-resistant
strains.
This
comprehensive
review
summarizes
mechanisms
in
concentrates
on
history,
mode
action,
implications
colistin.
We
mainly
focused
fundamental
mediated
chromosomal
or
plasmid
elements
discussed
major
mutations
two-component
systems
(TCSs)
genes
plasmids
transmit
mobilized
resistant
One Health Advances,
Год журнала:
2023,
Номер
1(1)
Опубликована: Март 30, 2023
Abstract
As
a
pathogen
of
major
public
health
concern
with
animal
importance,
Campylobacter
constitutes
clear
and
present
threat
to
One
Health.
This
organism
colonizes
the
intestinal
tract
is
widely
distributed
among
various
species,
including
livestock
poultry,
companion
animals,
wildlife.
result
its
broad
distribution,
exposed
antibiotics
used
in
both
human
veterinary
medicine,
which
creates
antibiotic
selection
pressure
that
has
driven
development
rising
prevalence
resistant
.
particularly
evident
resistance
fluoroquinolone
(FQ),
become
great
for
health.
However,
increased
antibiotic-resistant
cannot
be
solely
attributed
usage,
as
interspecies
transmission
subsequent
clonal
expansion
also
contribute
dissemination
exemplified
by
emergence
FQ-resistant
clones
production
systems
where
FQ
were
never
used,
extensively
drug
from
dogs
patients,
spread
hypervirulent
ruminants
humans.
Another
notable
finding
recently
published
work
genes
Gram-positive
origin
,
suggesting
genetic
exchange
between
bacteria
occurs
natural
environment
more
frequent
than
previously
realized.
Once
these
“foreign”
are
presented
they
can
further
disseminate
or
horizontal
gene
transfer
different
species/strains.
These
findings
indicate
ecosystem
complex
multidirectional,
affected
multiple
factors.
Thus,
holistic
Health
approach
necessary
fully
comprehend
mitigate
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(2), С. 3608 - 3619
Опубликована: Янв. 2, 2025
Bacterial
biofilms
are
complex
multicellular
communities
that
adhere
firmly
to
solid
surfaces.
They
widely
recognized
as
major
threats
human
health,
contributing
issues
such
persistent
infections
on
medical
implants
and
severe
contamination
in
drinking
water
systems.
As
a
potential
treatment
for
biofilms,
this
work
proposes
two
strategies:
(i)
light-driven
ZnFe2O4
(ZFO)/Pt
microrobots
photodegradation
of
(ii)
magnetically
driven
ZFO
mechanical
removal
from
Magnetically
were
realized
by
synthesizing
microspheres
through
low-cost
large-scale
hydrothermal
synthesis,
followed
calcination
process.
Then,
Pt
layer
was
deposited
the
surface
break
their
symmetry,
resulting
self-propelled
Janus
ZFO/Pt
microrobots.
Light-driven
exhibited
active
locomotion
under
UV
light
irradiation
controllable
motion
terms
"stop
go"
features.
capable
maneuvering
precisely
when
subjected
an
external
rotating
magnetic
field.
These
could
eliminate
Gram-negative
Escherichia
coli
(E.
coli)
photogenerated
reactive
oxygen
species
(ROS)-related
antibacterial
properties
combination
with
light-powered
locomotion,
accelerating
mass
transfer
remove
more
effectively
water.
Moreover,
actuation
allowed
physical
disruption
which
represents
reliable
alternative
photocatalysis
strongly
anchored
confined
spaces.
With
versatile
characteristics,
envisioned
highlight
significant
biofilm
high
efficacy
both
open
spaces,
pipelines
industrial
plants.
Journal of Global Antimicrobial Resistance,
Год журнала:
2021,
Номер
29, С. 499 - 506
Опубликована: Ноя. 18, 2021
Febrile
urinary
tract
infection
(UTI)
is
currently
considered
the
most
frequent
cause
of
serious
bacterial
illness
in
children
first
2
years
life.
UTI
paediatrics
can
irreversibly
damage
renal
parenchyma
and
lead
to
chronic
insufficiency
related
problems.
To
avoid
this
risk,
an
early
effective
antibiotic
treatment
essential.
Moreover,
prompt
mandatory
improve
clinical
condition
patient,
prevent
bacteraemia,
risk
localization
other
body
sites.
However,
resistance
for
UTI-related
pathogens
continuously
increases,
making
recommendations
rapidly
outdated
definition
best
empiric
therapy
more
difficult.
Variation
pathogen
susceptibility
antibiotics
essential
choice
therapy.
proper
identification
cases
at
increased
difficult-to-treat
UTIs
reduce
ineffective
In
review,
problem
emerging
among
associated
with
development
paediatric
febrile
potential
solutions
ensure
are
discussed.
Literature
analysis
showed
that
emergence
unavoidable
phenomenon
closely
correlated
use
themselves.
limit
resistance,
every
effort
rationalise
consumption
must
be
made.
An
stewardship
greatly
regard.
