Campylobacter,
predominantly
Campylobacter
jejuni,
is
a
global
foodborne
and
zoonotic
pathogen
responsible
for
significant
portion
of
the
gastroenteritis
diarrheal
illness
in
humans
worldwide.
Antibiotic-resistant
also
recognized
as
serious
threat
to
public
health
because
it
limits
treatment
options
increases
severity
infections.
Contaminated
poultry
meat
has
been
identified
most
common
source
infection
many
countries,
including
United
States.
Therefore,
effective
control
at
farm
level
would
greatly
reduce
spread
through
food
supply
chain.
In
this
project,
we
deciphered
association
between
colonization
gut
microbiota
composition
commercial
broilers.
We
evaluated
efficacy
using
fecal
transplantation
(FMT)
potential
method
reducing
Additionally,
assessed
impact
treating
broilers
with
enrofloxacin
(ENRO)
on
metabolic
processes.
The
key
findings
project
can
be
summarized
follows.
1)
Significant
differences
microbial
diversity
were
observed
cecal
structure
Campylobacter-negative
Campylobacter-positive
broiler
flocks
over
multiple
production
cycles.
2)
FMT
reduced
significantly
when
challenge
was
given
individual
birds
via
oral
gavage,
but
not
done
horizontally
by
use
seeder
birds.
3)
ENRO
initially
quickly
selected
fluoroquinolone
(FQ)-resistant
mutants
treated
4)
Both
treatments
altered
significantly;
additionally,
had
substantial
metabolism.
conclusion,
these
results
showed
that
differed
based
their
status
under
settings
could
substantially
influence
development
FQ-resistance
chicken
intestine
laboratory
conditions.
These
provide
valuable
insights
developing
microbiota-based
approaches
may
used
mitigate
broilers,
thereby
enhancing
safety
transmission
from
humans.
Pathogens,
Год журнала:
2024,
Номер
13(5), С. 356 - 356
Опубликована: Апрель 26, 2024
The
exploration
of
novel
biomarkers
to
assess
poultry
health
is
paramount
importance,
not
only
enhance
our
understanding
the
pathogenicity
zoonotic
agents
but
also
evaluate
efficacy
treatments
as
alternatives
antibiotics.
present
study
aimed
investigate
potential
gut
in
broiler
chicks
challenged
by
One Health,
Год журнала:
2025,
Номер
unknown, С. 101029 - 101029
Опубликована: Апрель 1, 2025
Zoonotic
Campylobacter
species
(ZCS),
particularly
C.
jejuni,
coli,
and
lari,
pose
significant
health
risks
to
humans
food-producing
animals
(FPAs).
This
study
investigates
the
prevalence,
geospatial
temporal
distributions
of
infections
(CSI)
in
Nigeria
from
2002
2023
through
a
systematic
review
meta-analysis
40
studies,
adhering
PRISMA
2020
guidelines.
The
overall
pooled
prevalence
CSI
was
33
%
(95
CI:
25
-
41
%),
with
variations
among
hosts:
poultry
(42
%,
95
27
57
(30
23
38
cattle
(21
15
32
%).
In
humans,
were
20.3
healthy
individuals,
23.8
diarrheic
patients,
34.2
HIV
patients.
coli
predominant
isolate
(87.5
%)
(38.1
while
jejuni
prevalent
(76.2
North-West
geopolitical
zone
exhibited
highest
at
Meta-regression
analysis
indicated
that
diagnostic
method
did
not
significantly
impact
(p
=
0.2170),
but
sample
type
explained
25.70
between-study
variance
(Wald
χ2
(2)
33.10,
p
<
0.0001).
Poultry
samples
showed
predicted
47.8
39.01
56.51
greater
than
18.3
8.9
27.8
%;
coefficient
0.2942,
0.001).
Sensitivity
analyses
minimal
changes
(33
confirming
robustness
findings
despite
high
heterogeneity
(I2
99.48
vs.
99.52
Temporal
peaked
between
2016
2020.
These
highlight
critical
importance
implementing
effective
biosecurity
measures
enhancing
food
safety
practices
mitigate
transmission
Nigeria,
zone,
which
rates.
adoption
One
Health
control
approach,
including
"farm
fork"
principle,
is
strongly
recommended
limit
human
by
ensuring
comprehensive
throughout
livestock
production
processing
value
chains.
Zoonotic Diseases,
Год журнала:
2025,
Номер
5(1), С. 5 - 5
Опубликована: Март 6, 2025
Zoonotic
diseases
pose
a
significant
global
health
threat,
driven
by
factors
such
as
globalization,
climate
change,
urbanization,
antimicrobial
resistance
(AMR),
and
intensified
human–animal
interactions.
The
increasing
interconnectedness
of
human,
animal,
environmental
underscores
the
importance
OH
paradigm
in
addressing
zoonotic
threats
globalized
world.
This
review
explores
complex
epidemiology
diseases,
challenges
associated
with
their
management,
necessity
for
cross-sector
collaboration
to
enhance
prevention
control
efforts.
Key
public
strategies,
including
surveillance
systems,
infection
measures,
community
education
programs,
play
crucial
roles
mitigating
outbreaks.
However,
gaps
governance,
resource
allocation,
interdisciplinary
cooperation
hinder
effective
disease
particularly
low-
middle-income
countries
(LMICs).
To
illustrate
effectiveness
approach,
this
highlights
successful
PREDICT
project,
Rwanda’s
National
One
Health
Program,
EcoHealth
Alliance,
Rabies
Elimination
Program
Philippines.
These
initiatives
demonstrate
how
integrating
efforts
can
early
detection,
improve
outbreak
responses,
reduce
burdens.
Strengthening
enhancing
infrastructure,
regulating
use,
investing
research
technological
innovations
are
essential
steps
toward
risks.
Ultimately,
coordinated,
multidisciplinary
approach
is
vital
dynamic
posed
ensuring
security
an
increasingly
interconnected
Objective:
The
zoonotic
pathogen
Campylobacter
is
a
major
foodborne
bacterial
species
worldwide.
distribution
and
drivers
of
antimicrobial
resistance
(AMR)
in
global
strains
remain
largely
unknown.
Therefore,
comprehensive
analysis
longitudinal
trends
driving
factors
AMR
necessary
at
level.
Methods:
We
downloaded
from
public
repositories
66,771
genomes
(24,115
C.
coli
42,656
jejuni
)
53
countries/regions
during
1954–2023,
performed
analysis.
Results:
categorized
the
isolates
into
2,771
sequence
types
(STs),
45
which
were
shared
among
humans,
chickens,
pigs,
cattle,
environment.
uncovered
spatial
temporal
characteristics
across
classes
on
scale,
observed
increased
aminoglycoside,
tetracycline,
fluoroquinolone
past
23
years.
Some
antibiotic,
climate,
socioeconomic
indicators
collected
World
Bank
might
potentially
have
driven
rise
various
to
varying
degrees.
Conclusions:
In
summary,
we
present
genetic
atlas
,
provides
valuable
insights
for
understanding
transmission
dynamics
this
species.
Journal of Global Antimicrobial Resistance,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Campylobacter
species
represent
one
of
the
leading
causes
human
foodborne
infections,
including
gastroenteritis
and
bloody
diarrhoea.
Overuse
antibiotics
in
veterinary,
agriculture,
humans
has
led
to
an
increase
multidrug
antimicrobial
resistance
(AMR).
Fluoroquinolones
macrolides
resistant
Campylobacters
are
WHO
CDC
priority
pathogens,
with
fluoroquinolone
doubling
past
20
years,
complicating
treatment.
Published
studies
relating
AMR
associated
molecular
mechanisms
both
jejuni
C.
coli
from
animals,
environment
(1981
-
2024),
were
retrieved
PubMed
Google
Scholar
using
relevant
keywords.
In
addition,
genomic
analyses
publicly
available
genomes
along
multi-locus
sequence
typing
results
PubMLST
database
used
analyse
these
determinants
their
phylogenomic
relationships.
Review
articles
excluded
analyses.
A
total
429
research
papers
reviewed
get
insights
into
coli.
Fluroquinolone
been
predominantly
international
travel.
The
gyrA
subunits
ecological
niches
overall,
it
is
suggestive
that
might
be
donor.
positive
synergism
was
observed
between
cmeA
gene
expression
quinolone
resistance.
Additionally,
speculated
possibility
horizontal
transfers
chromosomal
clusters
jejuni.
This
review
indicated
significant
concern
requires
continent-wide
surveillance
for
standard
practices
achieve
effective
stewardship.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 25, 2024
Food-borne
Campylobacter
jejuni
infections
constitute
serious
threats
to
human
health
worldwide.
Since
antibiotic
treatment
is
usually
not
indicated
in
infected
immune-competent
patients,
antibiotic-independent
approaches
are
needed
tackle
campylobacteriosis.
To
address
this,
we
orally
applied
carvacrol,
deferoxamine,
deoxycholate,
and
2-fucosyl-lactose
either
alone
or
all
combination
microbiota-associated
IL-10
−/−
mice
from
day
2
until
6
following
oral
C.
infection.
Neither
regimen
affected
loads
the
colon,
whereas
carvacrol
lowered
pathogen
numbers
ileum
on
post-infection
(p.i.).
The
regimens
resulted
alleviated
diarrheal
symptoms,
less
distinct
histopathological
apoptotic
epithelial
cell
responses
as
well
diminished
of
colonic
neutrophils
T
lymphocytes
p.i.,
latter
cells
were
also
decreased
upon
application.
Remarkably,
dampened
ex-vivo
IFN-γ
secretion
kidneys,
even
serum
basal
concentrations
p.i.
In
conclusion,
its
with
promising
antibiotics-independent
options
fight
acute
