Environmental Science & Technology,
Год журнала:
2024,
Номер
58(27), С. 11869 - 11886
Опубликована: Июнь 28, 2024
Developing
efficient
technologies
to
eliminate
or
degrade
contaminants
is
paramount
for
environmental
protection.
Biocatalytic
decontamination
offers
distinct
advantages
in
terms
of
selectivity
and
efficiency;
however,
it
still
remains
challenging
when
applied
complex
matrices.
The
main
challenge
originates
from
the
instability
difficult-to-separate
attributes
fragile
enzymes,
which
also
results
issues
compromised
activity,
poor
reusability,
low
cost-effectiveness,
etc.
One
viable
solution
harness
biocatalysis
environments
known
as
enzyme
immobilization,
where
a
flexible
tightly
fixed
solid
carrier.
In
case
reticular
crystal
utilized
support,
feasible
engineer
next-generation
biohybrid
catalysts
functional
complicated
media.
This
can
be
interpreted
by
three
aspects:
(1)
highly
crystalline
skeleton
shield
immobilized
against
external
stressors.
(2)
porous
network
ensures
high
accessibility
interior
catalytic
decontamination.
And
(3)
adjustable
unambiguous
structure
framework
favors
in-depth
understanding
interfacial
interaction
between
enzyme,
turn
guide
us
designing
active
biocomposites.
Review
aims
introduce
this
emerging
technology
involving
pollutant
degradation
greenhouse
gas
(carbon
dioxide)
conversion,
with
emphasis
on
immobilization
protocols
diverse
catalysis
principles
including
single
catalysis,
cascades,
photoenzyme-coupled
catalysis.
Additionally,
remaining
challenges
forward-looking
directions
field
are
discussed.
We
believe
that
may
offer
useful
biocatalytic
contribute
green
sustainable
manner
will
inspire
more
researchers
at
intersection
environment
science,
biochemistry,
materials
science
communities
co-solve
problems.
Clinical Infectious Diseases,
Год журнала:
2023,
Номер
77(Supplement_1), С. S29 - S37
Опубликована: Июль 1, 2023
Abstract
Background
Carbapenemase
production
is
a
global
public
health
threat.
Antimicrobial
resistance
(AMR)
data
analysis
critical
to
policy.
Here
we
analyzed
carbapenemase
detection
trends
using
the
AMR
Brazilian
Surveillance
Network.
Methods
from
hospitals
included
in
laboratory
information
system
dataset
were
evaluated.
The
rate
(DR)
was
defined
as
detected
by
gene
tested
per
isolate
year.
temporal
estimated
Prais–Winsten
regression
model.
impact
of
COVID-19
on
genes
Brazil
determined
for
period
2015–2022.
Detection
pre-
(October
2017
March
2020)
and
post-pandemic
onset
(April
2020
September
2022)
compared
χ2
test.
Analyses
performed
with
Stata
17.0
(StataCorp,
College
Station,
TX).
Results
83
282
blaKPC
86
038
blaNDM
all
microorganisms.
Enterobacterales
DR
68.6%
(41
301/60
205)
14.4%
(8377/58
172),
respectively.
P.
aeruginosa
2.5%
(313/12
528).
An
annual
percent
increase
41.1%
observed,
decrease
−4.0%
Enterobacterales,
an
71.6%
22.2%
aeruginosa.
From
2022,
overall
increases
65.2%
77.7%
ABC,
61.3%
observed
total
isolates.
Conclusions
This
study
shows
strengths
Network
robust
related
carbapenemases
change
profiles
rising
over
years.
Biomacromolecules,
Год журнала:
2023,
Номер
24(7), С. 3073 - 3085
Опубликована: Июнь 10, 2023
Antimicrobial
resistance
has
become
a
worldwide
issue,
with
multiresistant
bacterial
strains
emerging
at
an
alarming
rate.
Multivalent
antimicrobial
polymer
architectures
such
as
bottle
brush
or
star
polymers
have
shown
great
potential,
they
could
lead
to
enhanced
binding
and
interaction
the
cell
membrane.
In
this
study,
library
of
amphiphilic
copolymers
their
linear
copolymer
equivalents,
based
on
acrylamide
monomers,
were
synthesized
via
RAFT
polymerization.
Their
monomer
distribution
molecular
weight
varied.
Subsequently,
activity
toward
Gram-negative
bacterium
(Pseudomonas
aeruginosa
PA14)
Gram-positive
(Staphylococcus
aureus
USA300)
hemocompatibility
investigated.
The
statistical
copolymer,
S-SP25,
showed
improved
compared
its
equivalent
againstP.
aeruginosaPA14.
architecture
activity,
causing
aggregation,
revealed
electron
microscopy.
However,
it
also
induced
increased
red
blood
aggregation
equivalents.
Changing/shifting
position
cationic
block
core
structure
prevents
effect
while
maintaining
potent
for
smallest
copolymer.
Finally,
compound
antibiofilm
properties
against
robust
in
vitro
biofilm
model.
Sustainability,
Год журнала:
2023,
Номер
15(8), С. 6773 - 6773
Опубликована: Апрель 17, 2023
Sludge
generation
as
an
organic
by-product
of
wastewater
treatment
has
seen
a
consistent
increase
worldwide
due
to
population
growth
and
industrial
activities.
This
poses
chronic
challenge
regarding
management
options
environmental
concerns.
The
agricultural
valorization
unconventional
materials
become
inevitable,
especially
in
semi-arid
arid
countries
that
suffer
from
depleted
soils
shortages
farm
manure
supply.
High-income
have
also
been
interested
this
recycling
practice
mitigate
landfilling
or
incineration
issues.
Sewage
some
sludges
contain
complex
mixture
beneficial
harmful
substances,
which
varies
with
the
origin
effluents.
Therefore,
sludge
land
application
should
be
well
managed
order
achieve
sustainable
agro-environmental
goals.
review
paper
focuses
on
different
aspects
related
reuse
agriculture,
starting
by
investigating
diversity
types
composition.
In
addition
preponderant
urban
sewage
sludge,
less-studied
sludges,
such
those
generated
pulp
mills
gas-to-liquid
industries,
are
hereby
addressed
well.
Then,
post-land
effects
discussed
relation
quality,
dose,
conditions.
present
examines
disparities
between
guidelines
determine
conformity
for
various
regions.
Accordingly,
special
attention
is
given
increasing
risks
emerging
pollutants
pharmaceuticals,
overused
since
outbreak
COVID-19
pandemic.
exhaustive
investigation
will
assist
establishment
strategies
safe
biosolids.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(27), С. 11869 - 11886
Опубликована: Июнь 28, 2024
Developing
efficient
technologies
to
eliminate
or
degrade
contaminants
is
paramount
for
environmental
protection.
Biocatalytic
decontamination
offers
distinct
advantages
in
terms
of
selectivity
and
efficiency;
however,
it
still
remains
challenging
when
applied
complex
matrices.
The
main
challenge
originates
from
the
instability
difficult-to-separate
attributes
fragile
enzymes,
which
also
results
issues
compromised
activity,
poor
reusability,
low
cost-effectiveness,
etc.
One
viable
solution
harness
biocatalysis
environments
known
as
enzyme
immobilization,
where
a
flexible
tightly
fixed
solid
carrier.
In
case
reticular
crystal
utilized
support,
feasible
engineer
next-generation
biohybrid
catalysts
functional
complicated
media.
This
can
be
interpreted
by
three
aspects:
(1)
highly
crystalline
skeleton
shield
immobilized
against
external
stressors.
(2)
porous
network
ensures
high
accessibility
interior
catalytic
decontamination.
And
(3)
adjustable
unambiguous
structure
framework
favors
in-depth
understanding
interfacial
interaction
between
enzyme,
turn
guide
us
designing
active
biocomposites.
Review
aims
introduce
this
emerging
technology
involving
pollutant
degradation
greenhouse
gas
(carbon
dioxide)
conversion,
with
emphasis
on
immobilization
protocols
diverse
catalysis
principles
including
single
catalysis,
cascades,
photoenzyme-coupled
catalysis.
Additionally,
remaining
challenges
forward-looking
directions
field
are
discussed.
We
believe
that
may
offer
useful
biocatalytic
contribute
green
sustainable
manner
will
inspire
more
researchers
at
intersection
environment
science,
biochemistry,
materials
science
communities
co-solve
problems.
