
The European Zoological Journal, Год журнала: 2024, Номер 91(2), С. 1093 - 1103
Опубликована: Июль 2, 2024
Язык: Английский
The European Zoological Journal, Год журнала: 2024, Номер 91(2), С. 1093 - 1103
Опубликована: Июль 2, 2024
Язык: Английский
Environmental Science & Technology, Год журнала: 2023, Номер 57(7), С. 2887 - 2897
Опубликована: Фев. 13, 2023
A novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant; hence, the knowledge of its long-term toxic effects and underlying mechanism would be critical for further health risk assessment. In present study, multi- transgenerational toxicity DBDPE was investigated in zebrafish upon life cycle exposure at environmentally relevant concentrations. The significantly increased malformation rate declined survival specifically occurred unexposed F2 larvae suggested development by DBDPE. changing profiles revealed transcriptome DNA methylome confirmed an susceptibility figured out potential disruptions glycolipid metabolism, mitochondrial energy neurodevelopment. changes biochemical indicators such as ATP production disturbance whereas alterations neurotransmitter contents light–dark stimulated behavior provided evidence neurotoxicity zebrafish. Our findings also highlighted necessity considering impacts when evaluating wild animals well human beings pollutants.
Язык: Английский
Процитировано
33TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 167, С. 117208 - 117208
Опубликована: Июль 29, 2023
Язык: Английский
Процитировано
25Environmental Geochemistry and Health, Год журнала: 2024, Номер 46(8)
Опубликована: Июль 2, 2024
Язык: Английский
Процитировано
13Environmental Toxicology, Год журнала: 2022, Номер 37(8), С. 2033 - 2043
Опубликована: Апрель 21, 2022
Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure harmful to animal human. Quail, as bird model, has been in the field of toxicology. However, there little information available literature about quail cerebrum damage caused by DLM. Here, we investigated effect on neurons. Four groups healthy quails were assigned (10 each group), respectively given 0, 15, 30, 45 mg/kg gavage for 12 weeks. Through measurements cerebrum, it was found that induced obvious histological changes, oxidative stress, neurons apoptosis. To further explore possible molecular mechanisms, performed real-time quantitative PCR detect expression endoplasmic reticulum (ER) stress-related mRNA such glucose regulated protein 78 kD, activating transcription factor 6, inositol requiring enzyme, kinase RNA (PKR)-like ER kinase. In addition, detected ATP content evaluate functional status mitochondria. The study showed significantly increased decreased tissues. These results suggest chronic induces apoptosis via promoting stress mitochondrial dysfunction. Furthermore, our provide novel explanation DLM-induced avian
Язык: Английский
Процитировано
38Environmental Science & Technology, Год журнала: 2023, Номер 57(44), С. 16811 - 16822
Опубликована: Окт. 25, 2023
The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant in the environment, which may evoke imperceptible effects humans or wild animals. Hence this study, zebrafish embryos were exposed to DBDPE (0, 0.1, 1, and 10 nM) until sexual maturity (F0), F1 F2 generations cultured without further exposure study multi- transgenerational toxicity underlying mechanism. growth showed sex-different changing profiles across three generations, social behavior confirmed neurotoxicity adult upon life cycle DBDPE. Furthermore, maternal transfer of was not detected, whereas parental neurotransmitters zygotes specifically disturbed offspring. A lack changes generation opposite trends F0 observed series indicators for DNA damage, methylation, gene transcription. Taken together, at environmentally relevant concentrations could induce zebrafish. Our findings also highlighted potential impacts on gregarious fish, would face higher risks from predators.
Язык: Английский
Процитировано
19Environmental Toxicology and Pharmacology, Год журнала: 2023, Номер 100, С. 104155 - 104155
Опубликована: Май 18, 2023
Язык: Английский
Процитировано
11Journal of Applied Toxicology, Год журнала: 2023, Номер 44(4), С. 488 - 500
Опубликована: Сен. 12, 2023
Abstract Based on the 87 original publications only from quartiles 1 and 2 of Journal Citation Report (JCR) collected by major academic databases (Science Direct, Web Science, PubMed, Wiley) in 2022, frontier toxicology studies zebrafish model is summarized. Herewith, a total six aspects covered such as developmental, neurological, cardiovascular, hepatic, reproductive, immunizing toxicities. The tested samples involve chemicals, drugs, new environmental pollutants, nanomaterials, its derivatives, along with those related mechanisms. This report may provide focus benefit to researchers engaging for environment, medicine, food, other fields.
Язык: Английский
Процитировано
10Veterinární Medicína, Год журнала: 2024, Номер 69(3), С. 77 - 83
Опубликована: Март 28, 2024
This study investigated the impact of deltamethrin (DM) toxicity on brown trout (Salmo trutta fario), examining its effects immune system, including white blood cell (WBC), lymphocyte (Lym), total immunoglobulin (T. Ig), and lysozyme levels, as well neurotoxic consequences brain tissue. The encompassed oxidative stress, activity antioxidant enzymes, such superoxide dismutase (SOD) catalase (CAT), acetylcholinesterase (AChE) activity, DNA damage using 8-hydroxy-2-deoxyguanosine (8-OHdG). DM exposure led to elevated levels malondialdehyde (MDA), 8-OHdG, while concurrently causing a reduction in AChE protein lipid content, WBC count, Lym, T. Ig SOD CAT tissues groups 2 3 when compared those group 1. In summary, findings this strongly indicate that induces damage, immunotoxicity, neurotoxicity tissue trout, primarily due excessive production reactive oxygen species (ROS). Moreover, observed dose-dependent responses environmental concentrations all parameters suggest potential utility aquaculture risk assessment.
Язык: Английский
Процитировано
3Food Chemistry, Год журнала: 2025, Номер 471, С. 142757 - 142757
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
0Frontiers in Veterinary Science, Год журнала: 2025, Номер 11
Опубликована: Янв. 23, 2025
Background Deltamethrin (DM) is a broad-spectrum insecticide that widely used to control agricultural pests. Recently, DM has posed potential threat the health of infants and young children, this because environmental food pollution caused by extensive use DM. Methods In study, zebrafish ( Danio rerio ) embryos were as experimental animals quantify behavioral changes larvae induced explore relationship between acetylcholinesterase activity. Results The results showed an increase in coiling movement, heart rate, apoptosis brain early or larvae. It also decrease expression acetylcholinesterase-associated genes activity acetylcholinesterase, which led content. transcriptome data low concentration acetylcholine-related gene signaling pathways. above suggest doses may induce neurodegeneration exposure inhibits leading cell Micro-injection at 2–4 stage knocked down overexpressed behavior enzyme had some effects. Conclusion This study explored change provide basis for treatment poisoning aquaculture.
Язык: Английский
Процитировано
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