A review of occurrence, bioaccumulation, and fate of novel brominated flame retardants in aquatic environments: A comparison with legacy brominated flame retardants

The Science of The Total Environment, Год журнала: 2024, Номер 939, С. 173224 - 173224

Опубликована: Май 17, 2024

Язык: Английский

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From cradle to grave: Deciphering sex-specific disruptions of the nervous and reproductive systems through interactions of 4-methylbenzylidene camphor and nanoplastics in adult zebrafish

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134298 - 134298

Опубликована: Апрель 12, 2024

Язык: Английский

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Co-exposure of decabromodiphenyl ethane and cadmium increases toxicity to earthworms: Enrichment, oxidative stress, damage and molecular binding mechanisms

Journal of Hazardous Materials, Год журнала: 2024, Номер 473, С. 134684 - 134684

Опубликована: Май 21, 2024

Язык: Английский

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Mechanistic and kinetic insights into the thermal degradation of decabromodiphenyl ethane

Environmental Pollution, Год журнала: 2024, Номер 359, С. 124539 - 124539

Опубликована: Июль 15, 2024

Язык: Английский

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Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Environment & Health, Год журнала: 2024, Номер 2(7), С. 424 - 440

Опубликована: Май 4, 2024

Triclosan (TCS) has garnered significant attention due to its widespread use and associated endocrine-disrupting effects. However, impact on the neuroendocrine system underlying mechanisms remain poorly understood. Here, we established correlations between TCS exposure serum sex hormone levels in participants of National Health Nutrition Examination Survey (NHANES). Additionally, investigated TCS's influence using adult zebrafish exposed environmentally relevant concentrations (0.361–48.2 μg/L) for 21 days. Assessment reproductive neurotoxicity included histopathological examination behavioral tests. Transcriptomics, proteomics analyses, biochemical detection were employed elucidate TCS-induced disruption. Significant found estradiol, testosterone, hormone-binding globulin NHANES participants. In addition, inhibited ovary development spermatogenesis zebrafish. Transcriptomics analysis revealed gender-specific key signaling metabolism-related pathways implicated toxicity. Moreover, induced nervous impairment, as evidenced by histological changes altered motor behavior, possibly with oxidative damage. Correlation further highlighted potential connection endocrine disruption impairment following exposure. Overall, this study provided evidence supporting offered insights into mechanisms.

Язык: Английский

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Integrative Proteomics and Metabolomics Approach to Elucidate the Cardiotoxicity of Decabromodiphenyl Ethane in Zebrafish Larvae

Опубликована: Янв. 1, 2025

Язык: Английский

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Synergistic toxicity of DBDPE and Cd in a microcosm agrosystem: Insights into physiological, biochemical, nutrient elements and amino acid metabolic responses

Journal of Hazardous Materials, Год журнала: 2025, Номер 493, С. 138421 - 138421

Опубликована: Апрель 28, 2025

Язык: Английский

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Further negative effect of fibrous microplastics to the bioaccumulation and toxicity of decabromodiphenyl ethane on zebrafish

The Science of The Total Environment, Год журнала: 2025, Номер 980, С. 179577 - 179577

Опубликована: Май 3, 2025

Язык: Английский

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Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 290, С. 117781 - 117781

Опубликована: Янв. 1, 2025

Язык: Английский

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Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117870 - 117870

Опубликована: Фев. 1, 2025

Cadmium (Cd), a widespread and serious environmental pollutant, has recently garnered increasing scientific scrutiny due to its profound adverse effects. Although the evidence for Cd-induced reproductive toxicity is well established, it remains elusive on intricate dose-response relationship underlying molecular mechanisms, especially transgenerational in animals. Here, we employed fruit fly (Drosophila melanogaster) as model organism examine performance across five generations by parental exposure varying concentrations of Cd (5, 50, 500 μM). Firstly, our observations number eggs laid, pupae formed, adult flies emerged directly exposed generation (F0) confirmed dose-dependent decline fecundity. Transcriptome analysis revealed that, oxidative stress ion transport disruption F0 could underlie synaptic dysfunction impaired follicle cell development, impacting behavior oocyte fertility. Employing analysis, Wnt signaling pathway mTOR were identified early responses toxicity. Secondly, sustained detrimental effects observed at least two three after removal. At epigenetic level, perturb fecundity modulating Dnmt2 expression, pivotal regulator methylation processes. Moreover, despite phenotypic recovery F4, persistent changes indicate enduring toxicity, highlighting need vigilance against contamination long-term Collectively, findings enhance understanding effects, highlight further improve assessment multigenerational consequences contamination.

Язык: Английский

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