Ecotoxicology and Environmental Safety,
Год журнала:
2022,
Номер
243, С. 114007 - 114007
Опубликована: Авг. 26, 2022
2,
5-dichloro-1,
4-benuinone
(2,
5-DCBQ)
is
an
emerging
disinfection
by-product
belonging
to
the
class
of
halobenzoquinones
(HBQs).
However,
there
limited
evidence
regarding
neurotoxic
effects
5-DCBQ.
To
better
understand
toxicological
mechanisms
aquatic
organisms,
zebrafish
embryos
were
exposed
0.2
mg/L,
0.4
and
0.6
mg/L
5-DCBQ
from
4
h
post-fertilization
(hpf)
120
hpf.
Developmental
defects,
such
as
reduced
body
length,
decreased
heart
rate,
pigmentation,
abnormal
motor
axon
structure
was
observed.
In
particular,
locomotor
activity
larvae
with
exposure
increasing
concentrations,
this
effect
more
pronounced
under
dark
stimulation.
The
results
indicated
that
genes
associated
neuronal
development
(gfap,
mbp,
syn2a,
elavl3,
ache,
a1-tubulin)
significantly
downregulated
after
treatment
Furthermore,
KEGG
result
showed
neuroactive
ligand-receptor
interaction
apoptosis
pathways
visibly
disrupted,
we
found
acetylcholinesterase
also
affected.
summary,
by-product,
5-DCBQ,
exhibits
neurodevelopmental
toxicity
in
embryos,
providing
novel
for
comprehensive
analyses
its
toxicity.
Chemistry and Ecology,
Год журнала:
2023,
Номер
39(3), С. 235 - 255
Опубликована: Фев. 14, 2023
The
pesticide
ecosystem
impacts
are
very
diverse,
and
depending
on
their
persistence
could
exert
intrinsic
toxicity
within
an
acute
to
a
chronic
timeframe.
This
study
examined
the
toxic
effects
of
Diazinon
haematological
biochemical
endpoints
in
Oreochromis
mossambicus
after
exposure.
After
prior
range
fining
test,
fishes
were
exposed
predetermined
diazinon
concentrations
(T1-0.906
mg/L)
(T2-1.812
sampled
28
days
for
endpoints.
In
Diazinon-exposed
fish,
haemoglobin
content,
Total
Red
Blood
Cells,
White
MCH
levels
substantially
lower
(p
<
0.05)
than
control
fish
group.
total
blood
glucose
treated
greater
group,
whereas
serum
protein
significantly
0.05).
Observation
most
biomarkers
revealed
patterns
decreasing
values
with
increasing
toxicant
concentration
exposure
duration.
integrated
indices
(IBR
BRI)
indexes
used
provide
visual
understandable
depictions
emphasised
relativity
terms
sensitivity
magnitude
or
severity
responses
under
graded
exposures.
circumstances,
analysed
metrics
show
significant
impairment
mossambicus.
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology,
Год журнала:
2023,
Номер
268, С. 109597 - 109597
Опубликована: Март 6, 2023
Mancozeb
and
metalaxyl
are
fungicidal
agents
frequently
used
in
combination
to
control
fungi
crops
that
may
affect
non-target
organisms
when
entering
ecosystems.
This
study
aims
evaluate
the
environmental
effects
of
(MAN)
Metalaxyl
(MET),
alone
combination,
on
zebrafish
(Danio
rerio)
as
an
experimental
model.
The
oxidative
stress
biomarkers
transcription
genes
involved
detoxification
were
assessed
after
co-exposure
MAN
(0,
5.5,
11
μg
L-1)
MET
6.5,
13
mg
for
21
days.
Exposure
induced
a
significant
increase
expression
related
mechanisms
(Ces2,
Cyp1a,
Mt2).
Although
Mt1
gene
increased
fish
exposed
L-1
combined
with
MET,
was
down-regulated
significantly
other
groups
(p
<
0.05).
exposure
both
fungicides
showed
synergistic
levels
manifested
mainly
at
highest
concentration.
0.05)
alkaline
phosphatase
(ALP)
transaminases
(AST
ALT),
catalase
activities,
total
antioxidant
capacity,
malondialdehyde
(MDA)
contents
hepatocytes
detected,
lactate
dehydrogenase
(LDH),
gamma-glutamyl
transferase
(GGT)
hepatic
glycogen
content
decreased
Overall,
these
results
emphasize
can
synergistically
(except
Mt2)
biochemical
indicators
zebrafish.
Environmental Science and Pollution Research,
Год журнала:
2022,
Номер
29(51), С. 76687 - 76711
Опубликована: Сен. 29, 2022
Abstract
The
widespread
use
of
herbicides
has
increased
concern
about
the
hazards
and
risks
to
animals
living
in
terrestrial
aquatic
ecosystems.
A
comprehensive
understanding
their
effective
action
at
different
levels
biological
organization
is
critical
for
establishing
guidelines
protect
ecosystems
human
health.
Dinitroanilines
are
broad-spectrum
pre-emergence
currently
used
weed
control
conventional
agriculture.
They
considered
extremely
safe
agrochemicals
because
they
act
specifically
on
tubulin
proteins
inhibit
shoot
root
growth
plants.
However,
there
a
lack
toxicity
information
regarding
potential
risk
exposure
non-target
organisms.
aim
present
review
focus
side
effects
most
commonly
active
ingredients,
e.g.
pendimethalin,
oryzalin,
trifluralin
benfluralin,
animal
cells
invertebrates
vertebrates.
Acute
varies
from
slightly
high
species
(i.e.
nematodes,
earthworms,
snails,
insects,
crustaceans,
fish
mammals)
depending
species-specific
ability
tested
organisms
adsorb
discharge
toxicants.
Cytotoxicity,
genotoxicity
activation
oxidative
stress
pathways
as
well
alterations
physiological,
metabolic,
morphological,
developmental
behavioural
traits,
reviewed
here,
indicate
that
sublethal
concentrations
ingredients
poses
clear
hazard
humans.
Further
research
required
evaluate
molecular
mechanisms
these
cell
functions
multiple
levels,
communities,
including
commercial
formulations.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
251, С. 114554 - 114554
Опубликована: Янв. 20, 2023
Titanium
dioxide
nanoparticles
(n-TiO2)
could
enhance
the
bioavailability
and
toxicity
of
coexisting
organic
contaminants
in
aquatic
environment.
This
study
attempted
to
investigate
combined
effects
n-TiO2
difenoconazole
(DIF)
on
neurodevelopment
zebrafish
underlying
mechanisms.
In
this
study,
embryos
were
exposed
(100
μg/L),
DIF
(0,
0.1
0.5
mg/L)
their
mixtures
from
4
96
h
post
fertilization
(hpf)
neurotoxicity
was
evaluated.
Our
results
indicated
that
adsorbed
into
brain
significantly
enhanced
bioaccumulation
mg/L
co-exposure
group.
100
μg/L
not
developmentally
toxic
larvae,
but
it
exacerbated
DIF-induced
neurobehavioral
alterations
larvae.
also
aggravated
suppression
central
nervous
system
(CNS)
neurogenesis
Tg
(HuC:egfp)
zebrafish,
motor
neuron
axon
length
(hb9:egfp)
downregulation
neurodevelopmental
genes
(elavl3,
ngn1,
gap43,
gfap
mbp).
addition,
elevated
oxidative
stress
by
accumulation
reactive
oxygen
species
(ROS)
inhibition
antioxidant
enzymes,
triggered
apoptosis
upregulation
p53,
bax,
bcl-2
caspase-3,
which
markedly
intensified
presence
n-TiO2.
Moreover,
vitamin
C
(VC)
ameliorated
n-TiO2/DIF-induced
abnormal
locomotor
behaviors
inhibiting
apoptosis,
indicating
are
involved
neurotoxicity.
Taken
together,
our
data
heightened
thereby
inducing
exemplifies
importance
assessment
chemical
novel
insights
mitigate
toxicity.
Aquatic Toxicology,
Год журнала:
2023,
Номер
265, С. 106764 - 106764
Опубликована: Ноя. 10, 2023
Fish
maintain
their
body
fluid
ionic
and
osmotic
homeostasis
using
sophisticated
iono-/osmoregulation
mechanisms
through
gills
ionocytes.
Pesticide-induced
imbalance
in
fish
has
been
recognized
as
a
valuable
tool
to
determine
its
toxic
effects.
Acute
exposure
synthetic
organo-chemical
pesticides
on
the
regulation
of
(Na+,
Ca2+,
P)
metabolism
freshwater
catfish
Mystus
keletius
was
evaluated.
were
exposed
sub-lethal
concentrations
(mg/l)
selected
pesticide
for
period
7,
14,
21
28
days.
Results
indicated
that
chemical
-
Impala
Ekalux
evoked
adverse
effects
tissues
compared
tested.
Statistical
analysis
summative
data
two-way
ANOVA
significant
(p-value<0.001).
Variations
cellular
parameters
analysed
attributed
physiological
acclimatization
exposed.
Based
results
it
is
concluded
organic
may
be
preferred
rice
field
application
considering
safety
aspects.
Environmental Toxicology and Pharmacology,
Год журнала:
2024,
Номер
unknown, С. 104606 - 104606
Опубликована: Дек. 1, 2024
Neonicotinoid
insecticides
(NNIs)
are
the
fastest-growing
class
in
agricultural
protection.
They
target
nicotinic
acetylcholine
receptors
(nAChR)
pests,
stimulating
nervous
system
at
low
doses
and
causing
paralysis
death
higher
concentrations.
NNIs
used
crop
protection,
seed
treatment,
forestry,
agriculture,
flea
control
domestic
cattle.
Effective
lower
concentrations
offering
long-term
control,
favoured
for
their
systemic
activity.
However,
due
to
water
solubility,
mobility,
moderate
persistence,
easily
contaminate
adjacent
aquatic
environments
via
runoff,
leaching,
or
spray
drift.
While
less
toxic
vertebrates,
widespread
use
poses
threats
terrestrial
organisms,
neurotoxicity,
nephrotoxicity,
cytotoxicity,
genotoxicity,
immunotoxicity,
hepatotoxicity,
endocrine
disruption,
reproductive
malformations.
This
review
synthesizes
research
address
knowledge
gaps
on
environmental
impact
of
proposes
policies
mitigate
harmful
effects
non-target
species.
