Integrated multi-biomarker responses in Mozambique tilapia, Oreochromis mossambicus under acute and chronic Diazinon® exposures

Chemistry and Ecology, Год журнала: 2023, Номер 39(3), С. 235 - 255

Опубликована: Фев. 14, 2023

The pesticide ecosystem impacts are very diverse, and depending on their persistence could exert intrinsic toxicity within an acute to a chronic timeframe. This study examined the toxic effects of Diazinon haematological biochemical endpoints in Oreochromis mossambicus after exposure. After prior range fining test, fishes were exposed predetermined diazinon concentrations (T1-0.906 mg/L) (T2-1.812 sampled 28 days for endpoints. In Diazinon-exposed fish, haemoglobin content, Total Red Blood Cells, White MCH levels substantially lower (p < 0.05) than control fish group. total blood glucose treated greater group, whereas serum protein significantly 0.05). Observation most biomarkers revealed patterns decreasing values with increasing toxicant concentration exposure duration. integrated indices (IBR BRI) indexes used provide visual understandable depictions emphasised relativity terms sensitivity magnitude or severity responses under graded exposures. circumstances, analysed metrics show significant impairment mossambicus.

Язык: Английский

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Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 16, 2024

Abstract Premature ovarian failure (POF) caused by chemotherapy is a growing concern for female reproductive health. The use of metformin (MET), which has anti-oxidative and anti-inflammatory effects, in the treatment POF damaged drugs remains unclear. In this study, we investigated impact MET on cyclophosphamide (CTX) combined with busulfan (BUS) M1 macrophages using model mice primary granule cells (GCs). Our findings demonstrate that intragastric administration ameliorates damage alleviates hormonal disruption chemotherapy-induced mice. This effect achieved through reduction inflammatory oxidative stress-related harm. Additionally, significantly relieves abnormal response, ROS accumulation, senescence GCs co-cultured macrophages. We also observed protective role closely associated AMPK/PPAR-γ/SIRT1 pathway cell models. conclusion, our results suggest can protect against injury inducing expression AMPK while reducing inflammation.

Язык: Английский

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Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 106, С. 104377 - 104377

Опубликована: Янв. 23, 2024

Язык: Английский

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Impact of Feeding Frequency on Growth Performance and Antioxidant Capacity of Litopenaeus vannamei in Recirculating Aquaculture Systems

Animals, Год журнала: 2025, Номер 15(2), С. 192 - 192

Опубликована: Янв. 13, 2025

Feeding frequency is crucial for the growth and development of white shrimp (Litopenaeus vannamei) at various life stages. Although higher feeding frequencies can enhance growth, manual methods significantly increase labor costs. Automatic systems offer a cost-effective efficient alternative, yet their application in intensive culture remains under-researched. This study evaluates different L. vannamei aquaculture tanks, focusing on performance, survivability, feed utilization, digestive antioxidant capacities, economic viability. Juvenile (3.85 ± 0.3 g) were cultured 63 days with 6, 8, 10, 12 times/day (A6, A8, A10, A12 groups, respectively) using automatic feeders, control group fed manually 6 (M6). Results indicated that improved final body weight, specific rate, conversion ratio compared to feeding. Among A6 A8 showed optimal quadratic regression identifying 7.83 as frequency. While enzyme activity remained consistent across demonstrated levels (superoxide dismutase (SOD) glutathione peroxidase (GPx)) lower lipid peroxidation (MDA), suggesting superior capacities. Pearson's correlation confirmed positive relationship between SOD GPx. Economically, achieved highest profitability. Consequently, 6-8 feeders recommended an feasible strategy this stage.

Язык: Английский

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Multi-phase CdS loaded on biochar for photocatalytic activation of peroxymonosulfate for thiamethoxam degradation: π-conjugation improves PMS adsorption

Separation and Purification Technology, Год журнала: 2023, Номер 326, С. 124842 - 124842

Опубликована: Авг. 18, 2023

Язык: Английский

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Biochemical and Pathophysiological Responses in Capoeta capoeta under Lethal and Sub-Lethal Exposures of Silver Nanoparticles

Water, Год журнала: 2023, Номер 15(3), С. 585 - 585

Опубликована: Фев. 2, 2023

The increasing use of nano-based products raises concerns regarding potential risks related to their manufacturing, transportation, waste disposal, and management operations. We used the riverine carp, Capoeta capoeta, as an aquatic animal model demonstrate acute toxicity silver nanoparticles (Ag-NPs). This study focuses on first, then integrates findings through histopathology, hematological, biochemical testing lethal sub-lethal Ag-NPs exposures. Red blood corpuscles (RBC), white (WBC), hematocrit, total serum glucose levels were significantly lower in Ag-NPs-exposed fish than control fish. Total protein, triglycerides, cholesterol, albumin all greater exposed research focused impacts gills liver tissue, it was found that level injury escalated concentration Ag NPs increased. Epithelial lifting secondary lamellas (ELSL), epithelial hypertrophy (EH) lamellae (SL), leukocyte infiltration (LI), bottom hyperplasia (BH) detected In Ag-NPs-treated cross-sections macrophage aggregates (MA), fatty (FL), sinusoid dilatation (SD), necrosis (N) identified. dosages, according biomarker representations, elicit stress-specific physiological effects, compromising general overall health status animals. gradients toxic responses across exposure concentrations portrayals disrupted with nanoparticle time indicate a reduced ability for surviving wild.

Язык: Английский

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Oxidative stress, antioxidant defense responses, and histopathology: Biomarkers for monitoring exposure to pyrogallol in Clarias gariepinus

Journal of Environmental Management, Год журнала: 2023, Номер 351, С. 119845 - 119845

Опубликована: Дек. 17, 2023

Язык: Английский

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Behavioral and physiological toxicity thresholds of a freshwater vertebrate (Heteropneustes fossilis) and invertebrate (Branchiura sowerbyi), exposed to zinc oxide nanoparticles (nZnO): A General Unified Threshold model of Survival (GUTS)

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2022, Номер 262, С. 109450 - 109450

Опубликована: Сен. 1, 2022

Язык: Английский

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Effects of long-term Haematococcus pluvialis astaxanthin feeding on the growth, coloration, and antioxidant capacity of commercial-sized Oncorhynchus mykiss

Aquaculture Reports, Год журнала: 2023, Номер 30, С. 101603 - 101603

Опубликована: Май 18, 2023

Haematococcus pluvialis is an important source of natural astaxanthin, which plays a key role in the regulation color, antioxidant capacity, and immunity aquatic animals. However, it unclear that effects long-term H. astaxanthin feeding on growth performance, coloration, capacity commercial-sized rainbow trout Oncorhynchus mykiss. The commercial feed O. mykiss was used as basic feed, 15, 30 mg/kg were added to prepare isonitrogenous isolipidic experimental diets, defined HPA0, HPA15, HPA30, respectively. Juvenile with initial weight 0.60 kg fed three diets for 4 months, conducted investigate biochemical composition. results showed gain rate specific HPA30 from 0 months significantly higher than those other two diet groups. In 4th month, viscerosomatic index increased increasing dietary levels. redness (a*), DSM SalmoFan™ scores, content fillets levels during whole trial. activities total glutathione peroxidase serum liver, immunoglobulin (IgM) levels, while malondialdehyde liver decreasing trend. contents lipids fillet percentages saturated fatty acid (∑SFA), C18:3n3, n-3/n-6 PUFA ratio trend; C18:2n6 n-6 polyunsaturated acids (∑n-6PUFA) HPA15 HPA0. conclusion, four could improve

Язык: Английский

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Neurotoxic and cardiotoxic effects of pyrogallol on catfish (Clarias gariepinus)

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 109, С. 104481 - 104481

Опубликована: Июнь 9, 2024

Язык: Английский

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