International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11379 - 11379
Опубликована: Июль 12, 2023
The
global
rise
of
single-use
throw-away
plastic
products
has
elicited
a
massive
increase
in
the
nano/microplastics
(N/MPLs)
exposure
burden
humans.
Recently,
it
been
demonstrated
that
disposable
period
may
release
N/MPLs
with
usage,
which
represents
potential
threat
to
women's
health
not
scientifically
addressed
yet.
By
using
polyethyl
ene
(PE)
particles
(200
nm
9
μm),
we
showed
acute
high
concentration
induced
cell
toxicity
vaginal
keratinocytes
after
effective
cellular
uptake,
as
viability
and
apoptosis
data
suggest,
along
transmission
electron
microscopy
(TEM)
observations.
internalised
altered
expression
junctional
adherence
proteins
organisation
actin
cortex,
influencing
level
genes
involved
oxidative
stress
signalling
pathways
miRNAs
related
epithelial
barrier
function.
When
PE
was
discontinued
or
became
chronic,
cells
were
able
recover
from
negative
effects
on
differentiation/proliferation
gene
few
days.
However,
all
cases,
N/MPL
prompted
sustained
alteration
DNA
methyltransferase
demethylase
expression,
might
impact
epigenetic
regulation
processes,
leading
accelerated
ageing
inflammation,
occurrence
malignant
transformation.
ACS Nano,
Год журнала:
2023,
Номер
17(3), С. 2440 - 2449
Опубликована: Фев. 2, 2023
Nanoplastics
are
common
contaminants
in
the
living
environment.
Thus
far,
no
investigations
have
focused
on
small
intestinal
injury
offspring
of
adult
mice
that
were
exposed
to
nanoplastics
through
respiratory
system
during
pregnancy.
Here,
we
evaluated
potential
subjected
maternal
80
nm
polystyrene
nanoparticle
(PS-NP)
exposure
gestation.
PS-NP
significantly
reduced
birth
weight
female
compared
with
male
mice.
However,
body
weights
and
substantially
greater
PS-NP-exposed
groups.
Additionally,
found
PS-NPs
pregnancy
caused
histological
changes
intestines
both
offspring.
Mechanistic
analysis
revealed
upregulation
reactive
oxygen
species
intestines,
as
indicated
by
levels
superoxide
dismutase
(SOD)
malondialdehyde
(MDA).
Furthermore,
led
downregulation
GPx4,
FTH1,
FTL
protein
levels,
indicating
initiation
ferroptosis.
Notably,
mRNA
expression
differed
between
Although
all
phenotypes
failed
demonstrate
classic
dose-dependent
effects,
data
imply
toxicity
is
than
Our
results
suggest
causes
sex-specific
toxicity,
which
might
contribute
activation
subsequent
Overall,
this
study
showed
toxic
effects
after
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
278, С. 116426 - 116426
Опубликована: Май 8, 2024
The
increase
of
micro-
and
nano-plastics
(MNPs)
in
aquatic
environments
has
become
a
significant
concern
due
to
their
potential
toxicological
effects
on
ecosystems,
food
web
dynamics,
human
health.
These
plastic
particles
emerge
from
range
sources,
such
as
the
breakdown
larger
waste,
consumer
products,
industrial
outputs.
This
review
provides
detailed
report
transmission
dangers
MNPs
environmental
behavior,
interactions
within
webs,
emphasizing
toxic
impact
marine
life.
It
explores
relationship
between
particle
size
toxicity,
distribution
different
tissues,
process
trophic
transfer
through
web.
MNPs,
once
consumed,
can
be
found
various
organs,
including
digestive
system,
gills,
liver.
Their
consumption
by
lower
level
organisms
facilitates
progression
up
chain,
potentially
leading
bioaccumulation
biomagnification,
thereby
posing
substantial
risks
health,
reproduction,
behavior
species.
work
also
how
persistence
bioaccumulation,
pose
biodiversity
disrupt
relationships.
addresses
implications
for
particularly
contaminated
seafood,
highlighting
direct
indirect
pathways
which
humans
are
exposed
these
pollutants.
Furthermore,
highlights
recommendations
future
research
directions,
integration
ecological,
toxicological,
health
studies
inform
risk
assessments
develop
mitigation
strategies
address
global
challenge
pollution
environments.
Environment International,
Год журнала:
2024,
Номер
183, С. 108432 - 108432
Опубликована: Янв. 1, 2024
Micro-
and
nanoplastics
(MNPs),
emerging
as
pervasive
environmental
pollutants,
present
multifaceted
threats
to
diverse
ecosystems.
This
review
critically
examines
the
ability
of
MNPs
traverse
biological
barriers
in
fish,
leading
their
accumulation
gonadal
tissues
subsequent
reproductive
toxicity.
A
focal
concern
is
potential
transgenerational
harm,
where
offspring
not
directly
exposed
exhibit
toxic
effects.
Characterized
by
extensive
specific
surface
areas
marked
hydrophobicity,
readily
adsorb
concentrate
other
contaminants,
potentially
intensifying
comprehensive
analysis
aims
provide
profound
insights
into
repercussions
on
fish
health
progeny,
highlighting
intricate
interplay
between
pollutants.
We
delve
mechanisms
MNPs-induced
toxicity,
including
histopathologic
alterations,
oxidative
stress,
disruptions
hypothalamic-pituitary-gonadal
axis.
The
also
underscores
urgency
for
future
research
explore
size-specific
dynamics
long-term
implications
chronic
exposure.
Understanding
these
aspects
crucial
assessing
ecological
risks
posed
formulating
strategies
safeguard
aquatic
life.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 3, 2024
Abstract
In
recent
years,
the
environmental
health
issue
of
microplastics
has
aroused
an
increasingly
significant
concern.
Some
studies
suggested
that
exposure
to
polystyrene
(PS-MPs)
may
lead
renal
inflammation
and
oxidative
stress
in
animals.
However,
little
is
known
about
essential
effects
PS-MPs
with
high-fat
diet
(HFD)
on
development
microenvironment.
this
study,
we
provided
single-cell
transcriptomic
landscape
kidney
microenvironment
induced
by
HFD
mouse
models
unbiased
RNA
sequencing
(scRNA-seq).
The
injury
cell
atlases
mice
were
evaluated
after
continued
exposure,
or
treated
for
35
days.
Results
showed
plus
treatment
aggravated
profibrotic
microenvironment,
reshaping
cellular
components.
First,
found
acted
extracellular
matrix
organization
epithelial
cells,
specifically
proximal
distal
convoluted
tubule
inhibit
induce
ROS-driven
carcinogenesis.
Second,
activated
PI3K-Akt,
MAPK,
IL-17
signaling
pathways
endothelial
cells.
Besides,
markedly
increased
proportions
CD8
+
effector
T
cells
proliferating
Notably,
mononuclear
phagocytes
exhibited
substantial
remodeling
enriched
phosphorylation
chemical
carcinogenesis
treatment,
typified
alterations
tissue-resident
M2-like
PF4
macrophages.
Multispectral
immunofluorescence
immunohistochemistry
identified
macrophages
clear
carcinoma
(ccRCC)
adjacent
normal
tissues,
indicating
activate
might
regulate
pro-tumorigenic
injury.
conclusion,
study
first
systematically
revealed
molecular
variation
immune
scRNA-seq
approach,
which
a
basis
decoding
genitourinary
understanding
their
potential
mammals.
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