Per- and Polyfluoroalkyl Substances (PFAS) in Consumer Products: An Overview of the Occurrence, Migration, and Exposure Assessment

Molecules, Год журнала: 2025, Номер 30(5), С. 994 - 994

Опубликована: Фев. 21, 2025

Per- and polyfluoroalkyl substances (PFASs) have been widely used in the production of consumer products globally due to excellent water oil resistance anti-fouling properties. The multiple toxic effects some PFASs also pose a threat human health ecosystem, frequent use certain increased risk exposure PFASs. More data on occurrence, concentration, migration is urgently needed address possible risks posed by products. This paper reviews PFAS concentrations found, characteristics known, arising from several types over last five years. considered here include food contact materials, textiles, disposable personal hygiene influence different factors process these are summarized discussed. Additionally, main approaches models assessment evaluated summarized. Current challenges future research prospects this field discussed with view providing guidance for regulation

Язык: Английский

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Analytical approaches for screening of per- and poly fluoroalkyl substances in food items: A review of recent advances and improvements

Environmental Pollution, Год журнала: 2023, Номер 329, С. 121705 - 121705

Опубликована: Апрель 26, 2023

Язык: Английский

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Legacy and alternative per- and polyfluoroalkyl substances spatiotemporal distribution in China: human exposure, environmental media, and risk assessment

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 135795 - 135795

Опубликована: Сен. 12, 2024

Язык: Английский

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Current understanding of human bioaccumulation patterns and health effects of exposure to perfluorooctane sulfonate (PFOS)

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137249 - 137249

Опубликована: Янв. 16, 2025

Язык: Английский

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Per- and polyfluoroalkyl substances (PFAS) in breast milk and infant formula: A global issue

Environmental Research, Год журнала: 2022, Номер 219, С. 115042 - 115042

Опубликована: Дек. 16, 2022

Per- and polyfluoroalkyl substances (PFAS) are transferred from mother to infants through breastfeeding, a time when children may be particularly vulnerable PFAS-mediated adverse health effects. Infants can also exposed PFAS infant formula consumption. Our recent literature-based scoping of breast milk levels reported that four often exceeded the United States Agency for Toxic Substances Disease Registry (ATSDR) children's drinking water screening in both general population highly impacted communities U.S. Canada. This work presents comparison global measurements with only health-based values specific children. We focused on which ATSDR has developed values: PFOA (perfluorooctanoic acid), PFOS (perfluorooctanesulfonic PFHxS (perfluorohexanesulfonic PFNA (perfluorononanoic acid). Published literature were identified via PubMed searches. Data compared values. Breast concentrations exceed values, regardless geographic location. The limited information suggests its use does not necessarily result lower exposures, especially formulas reconstituted containing PFAS. Unfortunately, individuals generally cannot know whether their infant's exposures Thus, it is essential pregnant lactating women others, those having lived PFAS-contaminated communities, have data required make informed decisions nutrition. An international monitoring effort access affordable testing needed milk, fully understand exposures. Currently, our understanding demonstrable methods reducing emerging limited, making this research communications surrounding even more important.

Язык: Английский

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Occurrences of legacy and emerging per- and polyfluoroalkyl substances in human milk in China: Results of the third National Human Milk Survey (2017–2020)

Journal of Hazardous Materials, Год журнала: 2022, Номер 443, С. 130163 - 130163

Опубликована: Окт. 12, 2022

Язык: Английский

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Concentrations of Per- and Polyfluoroalkyl Substances in Paired Maternal Plasma and Human Milk in the New Hampshire Birth Cohort

Environmental Science & Technology, Год журнала: 2022, Номер 57(1), С. 463 - 472

Опубликована: Дек. 27, 2022

Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent endocrine-disrupting chemicals associated with long-term health outcomes. PFAS transferred from maternal blood to human milk, an important exposure source for infants, understanding of this transfer is evolving. We characterized concentrations 10 in milk (n = 426) compared milk-to-plasma 9 among a subset women paired samples 294) the New Hampshire Birth Cohort Study using liquid chromatography-isotope dilution tandem mass spectrometry. examined relationship between perfluorooctanoate (PFOA) perfluorooctane sulfonate (PFOS) plasma versus fit linear regression models assess relationships PFOA PFOS participant characteristics. The median concentration was 0.94 ng/mL (interquartile range, IQR, 0.59–1.34) that 2.60 (IQR 1.80–3.90); 0.017 0.012–0.027) 0.024 0.016–0.036). showed correlations ρ 0.83 0.77, respectively (p < 0.001). Parity, previous lactation, week collection, body index were inversely PFAS. estimate even our general population cohort, some infants (∼6.5%) exposed amounts via may have impacts.

Язык: Английский

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Per- and polyfluoroalkyl substances (PFAS): Trends in mass spectrometric analysis for human biomonitoring and exposure patterns from recent global cohort studies

Environment International, Год журнала: 2024, Номер 194, С. 109117 - 109117

Опубликована: Ноя. 7, 2024

Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants that have been shown to contribute human exposure, thereby raising a range of health concerns. In this context, biomonitoring is essential for linking exposure levels PFAS with their potential risks. Mass spectrometry-based analytical techniques extensively adopted the evaluation across various cohorts. However, challenges arising from use biological samples (e.g., plasma, serum, urine, etc.) necessitate ongoing research refinement methodologies. This review provides an overview current trends in mass approaches PFAS, including sample collection preparation, instrumental techniques. We also explore strategies overcome obtaining PFAS-free blank matrices address risk background contamination. Moreover, examines differing patterns regions by analyzing recent international cohort studies, specifically those conducted US China over past five years. Accordingly, several key gaps studies need be addressed moving forward highlighted.

Язык: Английский

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Serum concentrations of legacy, alternative, and precursor per- and polyfluoroalkyl substances: a descriptive analysis of adult female participants in the MIREC-ENDO study

Environmental Health, Год журнала: 2024, Номер 23(1)

Опубликована: Июнь 10, 2024

Abstract Background Several legacy and emerging per- polyfluoroalkyl substances (PFAS) have been regulated around the world. There is growing concern over proliferation of alternative PFAS, as well PFAS precursors. Biomonitoring data for are critical assessing exposure human health risk. Methods We collected serum samples from 289 adult female participants in a 2018–2021 follow-up study Maternal-Infant Research on Environmental Chemicals (MIREC) Canadian pregnancy cohort. Samples were analyzed 40 using ultra-performance liquid chromatography–tandem mass spectrometry. For those compounds with > 50% detection, sum these compounds, we describe concentrations patterns according to sociodemographic obstetrical history characteristics. Results 17 out detected 7 97% samples. Median [95th percentile] (µg/L) highest PFOS (1.62 [4.56]), PFOA (0.69 [1.52]), PFNA (0.38 [0.81]), PFHxS (0.33 [0.92]). Geometric mean approximately 2-fold lower among more children (≥ 3 vs. 1), greater number breastfed ≤ longer lifetime duration breastfeeding (> 4 years 9 months), shorter time since last (≤ 8 years). observed similar PFOS, PFHpS, though differences between groups smaller. Concentrations higher “White” participants, while N-MeFOSE, N-EtFOSE, 7:3 FTCA, 4:2 FTS slightly reporting race or ethnicity other than “White”. legacy, alternative, precursor generally across levels age, education, household income, body index, menopausal status. Conclusions report first biomonitoring several PFAS. Our findings suggest that including alternatives, may be widespread. results consistent previous studies showing excretion pathways

Язык: Английский

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Perfluorooctanoic Acid and Perfluorooctane Sulfonate in Human Milk: First Survey from Lebanon

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(1), С. 821 - 821

Опубликована: Янв. 1, 2023

Human milk is the primary source of nutrition for infants in their first year life. Its potential contamination with perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), a group toxic man-made chemicals, health concern that may threatens infants’ health. Our study aims to assess levels PFOA PFOS breast Lebanese lactating mothers maternal factors associated presence. High-performance liquid chromatography (HPLC) coupled Micromass Quattro micro API triple quadrupole mass spectrometer was used detect level 57 collected human samples. were present 82.5% 85.7% samples, respectively, while ranged between 120 247 pg/mL median 147 pg/mL, those 12 86 27.5 pg/mL. The exceeded threshold set by European Food Safety Authority (EFSA) (60 pg/mL); however, below (73 pg/mL). consumption bread, pasta, meat, chicken more than twice per week white tubers roots at least once significantly higher (p < 0.05). No significant association found age, BMI, parity, education, place residence, water used, smoking milk. Additionally, cereals PFOS. These findings call actions improve local environmental agricultural practices, regulations standards inspecting imported food. It important highlight benefits breastfeeding outweigh reported our study.

Язык: Английский

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