Per- and Polyfluoroalkyl Substances (PFAS) in Consumer Products: An Overview of the Occurrence, Migration, and Exposure Assessment

Molecules, Год журнала: 2025, Номер 30(5), С. 994 - 994

Опубликована: Фев. 21, 2025

Per- and polyfluoroalkyl substances (PFASs) have been widely used in the production of consumer products globally due to excellent water oil resistance anti-fouling properties. The multiple toxic effects some PFASs also pose a threat human health ecosystem, frequent use certain increased risk exposure PFASs. More data on occurrence, concentration, migration is urgently needed address possible risks posed by products. This paper reviews PFAS concentrations found, characteristics known, arising from several types over last five years. considered here include food contact materials, textiles, disposable personal hygiene influence different factors process these are summarized discussed. Additionally, main approaches models assessment evaluated summarized. Current challenges future research prospects this field discussed with view providing guidance for regulation

Язык: Английский

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Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvae

Environment International, Год журнала: 2023, Номер 176, С. 107977 - 107977

Опубликована: Май 15, 2023

Several per- and polyfluoroalkyl substances (PFAS) have been linked to metabolic disorders in organisms. However, few studies considered their combined effects, which would be more representative of PFAS occurring the environment. In this study, zebrafish embryos were exposed a mixture 18 at three environmentally relevant concentrations for 5 days assess bioconcentration consequences. The burdens ∑PFAS larvae 0.12, 1.58, 9.63 mg/kg 0.5, 5, 50 μg/L treatment groups, respectively. Exposure accelerated hatching larval heart rates, increased energy expenditure, reduced ATP levels glucose contents due decreased feed intake uptake. Metabolomic analysis revealed that exposure enhanced glycolysis but inhibited phospholipid synthesis, significantly expression lipid metabolism related genes (srebf1, acox, pparα), indicated β-oxidation. significant changes mitochondrial membrane potential, content, transcription involved respiratory chain (mfn2, ndufs1, atp5fa1, mt-nd1) DNA replication (18rs-rrn, polg1) suggested could cause dysfunction further disrupt pathways, ultimately causing larvae. These findings demonstrate importance assessing effects mixtures on early development wildlife humans.

Язык: Английский

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Occurrence, behaviors, and fate of per- and polyfluoroalkyl substances (PFASs) in typical municipal solid waste disposal sites

Water Research, Год журнала: 2024, Номер 252, С. 121215 - 121215

Опубликована: Янв. 27, 2024

Язык: Английский

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Determinants of PFOA Serum Half-Life after End of Exposure: A Longitudinal Study on Highly Exposed Subjects in the Veneto Region

Environmental Health Perspectives, Год журнала: 2024, Номер 132(2)

Опубликована: Фев. 1, 2024

Perfluoroalkyl substances (PFAS) are widely used, ubiquitous, and highly persistent man-made chemicals. Groundwater of a vast area the Veneto Region (northeastern Italy) was found to be contaminated by PFAS from manufacturing plant active since late 1960s. As result, residents were overexposed through drinking water until 2013, mainly perfluorooctanoic acid (PFOA).

Язык: Английский

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Association of diet with per- and polyfluoroalkyl substances in plasma and human milk in the New Hampshire Birth Cohort Study

The Science of The Total Environment, Год журнала: 2024, Номер 933, С. 173157 - 173157

Опубликована: Май 11, 2024

Язык: Английский

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Per- and Polyfluoroalkyl Substances and Breastfeeding as a Vulnerable Function: A Systematic Review of Epidemiological Studies

Toxics, Год журнала: 2023, Номер 11(4), С. 325 - 325

Опубликована: Март 29, 2023

Milk formation in the breast during breastfeeding is a complex hormonally regulated process, potentially sensitive to effects of endocrine-disrupting chemical exposures. The environmental chemicals, per- and polyfluoroalkyl substances (PFAS) are known endocrine disruptors. PFAS exposure have been associated with insufficient mammary gland development mice reduced duration humans. aim this review was gather epidemiological evidence on association between duration. Using PubMed Embase, we performed systematic literature search (on 23 January 2023) identify studies examining maternal Animal studies, reviews, non-English were excluded. risk bias assessed using non-randomized exposures tool. Estimates describing identified, data synthesized separately for each type exclusive total breastfeeding. Six 336 2374 participants identified. serum samples (five studies) or based residential address (one study). Five out six found shorter higher exposure. most consistent associations seen perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic (PFNA). finding potential causal agreement findings from experimental studies.

Язык: Английский

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Per- and polyfluoroalkyl substances (PFAS): Trends in mass spectrometric analysis for human biomonitoring and exposure patterns from recent global cohort studies

Environment International, Год журнала: 2024, Номер 194, С. 109117 - 109117

Опубликована: Ноя. 7, 2024

Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants that have been shown to contribute human exposure, thereby raising a range of health concerns. In this context, biomonitoring is essential for linking exposure levels PFAS with their potential risks. Mass spectrometry-based analytical techniques extensively adopted the evaluation across various cohorts. However, challenges arising from use biological samples (e.g., plasma, serum, urine, etc.) necessitate ongoing research refinement methodologies. This review provides an overview current trends in mass approaches PFAS, including sample collection preparation, instrumental techniques. We also explore strategies overcome obtaining PFAS-free blank matrices address risk background contamination. Moreover, examines differing patterns regions by analyzing recent international cohort studies, specifically those conducted US China over past five years. Accordingly, several key gaps studies need be addressed moving forward highlighted.

Язык: Английский

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Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet

Environment International, Год журнала: 2024, Номер 186, С. 108621 - 108621

Опубликована: Апрель 1, 2024

In utero and children's exposure to per- polyfluoroalkyl substances (PFAS) is a major concern in health risk assessment as early life exposures are suspected induce adverse effects. Our work aims estimate (from birth 12 years old) PFOA PFOS, using Physiologically-Based Pharmacokinetic (PBPK) modelling approach. A model for PFAS was updated simulate the internal during childhood, including individual characteristics scenarios (e.g., duration of breastfeeding, weight at birth, etc.). approach applied HELIX cohort, involving 1,239 mother–child pairs with measured PFOS plasma concentrations two sampling times: maternal child (6 y.o). predicted an increase fetal development childhood until 2 y.o when maximum were reached. Higher than y.o, then gradually became higher concentrations. From 8 mean decreased from 3.1 1.88 µg/L or ng/mL (PFOA) 4.77 3.56 (PFOS). The concentration–time profiles vary age mostly influenced by (on first 4 months after birth), breastfeeding 5 (PFOS) children), food intake (after 3 6 children). Similar biomarker levels can correspond large differences simulated exposures, highlighting importance investigate over improve classification. demonstrates possibility PBPK models biomarkers scarce, helping assessors gaining insight into critical windows, such life.

Язык: Английский

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Per- and polyfluoroalkyl substances (PFAS) in powdered infant formula: potential exposures and health risks

Journal of Environmental Exposure Assessment, Год журнала: 2024, Номер 3(2)

Опубликована: Июнь 11, 2024

Per- and polyfluoroalkyl substances (PFAS) are a class of human-made persistent, bioaccumulative, toxic compounds. People can be exposed to PFAS through many different pathways, including food, drinking water, PFAS-containing consumer products. Infants recognized as particularly susceptible the harmful effects while also being among most highly populations. Exposure begins in utero via placental transfer continue after birth from environmental exposures breastfeeding. PFAS-contaminated if used mix infant formula, is an important potential exposure route for formula-fed infants because they consume more fluid on per-body-weight basis than older individuals. However, data about powdered formula itself lacking. To address this gap, we analyzed 17 formulas 10 PFAS. Only one type PFAS, perfluorooctanesulfonic acid (PFOS), was detected single dairy-based at reconstituted concentration 8.9 ng/L. Using our recently updated toxicokinetic model, estimated serum PFOS curves over first year life various scenarios, intake rates, with uncontaminated contaminated without transfer. Our analytical results indicate detection not major source relative other sources, risk assessment comparing scenarios Minnesota Department Health’s 2024 reference (2.6 ng/mL) concludes that likely does pose significant infants.

Язык: Английский

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Engineering human midbrain organoid microphysiological systems to model prenatal PFOS exposure

The Science of The Total Environment, Год журнала: 2024, Номер 947, С. 174478 - 174478

Опубликована: Июль 2, 2024

Язык: Английский

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